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| Number | Title | Issue Date |
| 8158782 | Biomolecule labeling reactants based on azacycloalkanes and conjugates derived thereof This invention concerns novel labeling reactants based on azacycloalkanes, wherein a suitable group is linked to the molecule allowing introduction of the said molecules to bioactive molecules in solution or on solid phase. ... | 04/17/2012 |
| 8138332 | Synthesis of cyclen derivatives The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure givin... | 03/20/2012 |
| 8110679 | Nanofilm and membrane compositions Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a subs... | 02/07/2012 |
| 7777029 | Bifunctional chelators for sequestering lanthanides The present invention relates to a method for preparing a bifunctional chelator for lanthanide. The method comprises the steps of providing a starting material which has an amino and carboxyl group; protecting the amino with an amino protecting group and the carboxy... | 08/17/2010 |
| 7488820 | Naphthofluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to naphthofluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 02/10/2009 |
| 7432371 | Nanofilm and membrane compositions Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a subs... | 10/07/2008 |
| 7414065 | Methods to modulate conditions mediated by the CXCR4 receptor The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well... | 08/19/2008 |
| 7390828 | Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis a... | 06/24/2008 |
| 7385054 | Trimeric, macrocyclically substituted halo-benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media. ... | 06/10/2008 |
| 7371579 | Nickel-based reagents for detecting DNA and DNA-protein contacts The invention relates to a compound comprising a labeled nickel complex (FIG. 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex. The adduct can also be purified... | 05/13/2008 |
| 7368100 | Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N′,N″,N′″-tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 05/06/2008 |
| 7358052 | Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii... | 04/15/2008 |
| 7354932 | Chemokine receptor binding heterocyclic compounds with enhanced efficacy The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and opt... | 04/08/2008 |
| 7351389 | Aminocarboxylate ligands having substituted aromatic amide moieties Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R13, A1, R1 and R2 are as... | 04/01/2008 |
| 7335629 | Support-fixed bleaching catalyst complex compounds suitable as catalysts for peroxygen compounds The present invention relates to support-fixed bleaching catalyst(s)suitable or the catalysis of peroxide compounds, characterized in that the support-fixed bleaching catalyst(s) is/are covalently bonded to a support by means of at least one organic ligand of the bl... | 02/26/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7319038 | Sensor for monitoring an analyte A food spoilage sensor of the general formula wherein M is a transition metal ion; D1, D2, D3 and D4 can be the same or different and can be N or P; R1 and R... | 01/15/2008 |
| 7319094 | Increased and sustained in vivo gene expression using a nucleic acid, histone and amphipathic compound composition The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death. ... | 01/15/2008 |
| 7312234 | Chemokine receptor binding heterocyclic compounds Tertiary amines containing a multiplicity of heteroaromatic substituents are useful as chemokine receptor modulators. ... | 12/25/2007 |
| 7312327 | Method of preparing nitrogen macrocycles The invention relates to a method of preparing nitrogen macrocycles having formula (I). The inventive method comprises a step involving the reaction of compounds (II) and (III) in order to form a compound having formula (IV). Said compound is subsequently made to re... | 12/25/2007 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7291631 | CXCR4 chemokine receptor binding compounds The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention als... | 11/06/2007 |
| 7282215 | Supports for photosensitizer formulations The invention is generally related to the field of formulating medicaments in association with a solid support. Such formulations comprising photosensitizers, and their use in photodynamic therapy, are also provided. Methods for the production of the medicament form... | 10/16/2007 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7267994 | Element-coded affinity tags The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, ... | 09/11/2007 |
| 7255999 | Methods and compositions for analyzing proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducin... | 08/14/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7217531 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 05/15/2007 |
| 7214545 | Element-coded affinity tags The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, ... | 05/08/2007 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7208140 | Trimeric macrocyclic substituted benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine and A1 and A2 have different meanings, are suitable as contrast media. ... | 04/24/2007 |
| 7183273 | Chemokine receptor binding heterocyclic compounds Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor. ... | 02/27/2007 |
| 7169750 | Methods to mobilize progenitor/stem cells Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) ... | 01/30/2007 |
| 7164016 | Macrocyclic metal complexes and their use for the production of conjugates with biomolecules The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is ac... | 01/16/2007 |
| 7161000 | Method for producing phenol condensate Provided is a method for producing a phenol condensate by oxidative condensation of a phenol compound not having a substituted group on at least one ortho-position, in the presence of a specific complex (II) and oxygen, wherein a condensate coupled at para-position ... | 01/09/2007 |
| 7160872 | Methods to treat conditions mediated by chemokine receptors The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as othe... | 01/09/2007 |
| 7160735 | Tagged microparticle compositions and methods Compositions and methods are disclosed for detecting multiple target analytes in a sample using microparticles having molecular tags attached by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such micr... | 01/09/2007 |
| 7132513 | Bifunctional chelating agent The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents —NO2, —NH2, —NCS, —NHCOCH2-Z. NHCO—W—COCNHS, —NH-Q, —NHCS-Q, —NHCOCH2-Q, or —NHCO(CH2)m... | 11/07/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
