Class 540/472 - Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc., toxiferin)

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein (a) at least three members of one cycol
No. of patents: 210
Last issue date: 06/29/2010

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Number	Title	Issue Date
7745620	Disubstituted cucurbiturils and preparing method thereof Provided are a disubstituted cucurbituril that can be easily substituted by a substituent according to a desired usage and a method for preparing the same. The disubstituted cucurbituril has two end functional groups that can covalently bind with a solid substrate o...	06/29/2010
7498432	Method of synthesis of 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosane (1) and 1, 4, 7, 10, 13, 16, 21, 24-octaazabicyclo [8.8.8] hexacosa, 4, 6, 13, 15, 21, 23-hexaene (2) A process for producing compound 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosa, 4,6,13,15,21,23-hexaene (2) and then compound 1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane (1) from compound (2) is described. The process uses a reaction between triaminoet...	03/03/2009
7488819	Multidentate ligand A multidentate ligand includes at least two planar tetradentate coordination sites in one plane, each of the planar tetradentate coordination sites containing four nitrogen-containing groups of at least one of imino, amido and amino groups, and has the nitrogen atom...	02/10/2009
7427613	7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for t...	09/23/2008
7371754	Tyrosine kinase inhibitors The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a...	05/13/2008
7365194	Dimer of phenazine-1-carboxylic acid and to the process of preparation thereof A dimer of phenazine-1-carboyxlic acid natural products from fluorescent pseudomonad bacterium and a method of preparing a dimer of phenazine-1-carboxylic acid natural product are disclosed herein. The method comprises growing the bacterium in a water based liquid m...	04/29/2008
7351700	Aminomethylpyrimidines as allosteric enhancers of the GABA receptors The present invention relates to compounds of formula wherein X is —S— or —NH—; R3/R4 together with the N-atom to which they are attached for...	04/01/2008
7335768	Cucurbit [n] uril compounds and analogs, and methods of making and using the same Cucurbit[n]uril compounds each containing phthalhydrazide units in a macrocycle wall thereof, which compound is selected from the group consisting of CB[5], CB[6], CB[7] and CB[8] compounds, the compounds having an internal cavity which may be used to contain a gues...	02/26/2008
7312225	Macrocyclic pyrimidines, their production and use as pharmaceutical agents Macrocyclic pyrimidine derivatives of general formula I in which R1 to R5, X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent ...	12/25/2007
7282215	Supports for photosensitizer formulations The invention is generally related to the field of formulating medicaments in association with a solid support. Such formulations comprising photosensitizers, and their use in photodynamic therapy, are also provided. Methods for the production of the medicament form...	10/16/2007
7279502	Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions...	10/09/2007
7223753	Diazabicyclic biaryl derivatives This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the...	05/29/2007
7220741	1,4-diazabicycloalkane derivatives, their preparation and use This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the mono...	05/22/2007
7173149	Process for preparing alkynecarboxylic acids by oxidation of alkyne alcohols A process for preparing alkynecarboxylic acids includes the oxidation of an alkyne alcohol with a hypohalite in the presence of a nitroxyl compound at a pH of greater than 7 with continual addition of the alkyne alcohol and of the hypohalite to the reaction mixture....	02/06/2007
7166719	Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ...	01/23/2007
7160873	Texaphyrin coordination compounds and uses thereof Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed. ...	01/09/2007
7160466	Uses of cucurbituril devices Uses of cucurbituril derivatives are disclosed. The cucurbituril derivatives have the formula (1) where X is O, S or NH; R1 and R2 are independently selected from the group consisting of hyd...	01/09/2007
7147840	Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof A compound having the structural formula: where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 132-Oxo-bacteriopyropheophorbide—a carboxylic acid a...	12/12/2006
7122664	Cucurbituril-fullerene complex The present invention relates to a complex composed of cucurbituril and fullerene and a method for manufacturing the complex on a solid-phase. A complex in accordance with the present invention can be usefully used as a medicine delivery means in the field of...	10/17/2006
7122663	Stable free nitroxyl radicals as oxidation catalysts and process for oxidation The instant invention relates to stable free nitroxyl radicals of formula (I) wherein at least one of the substituents R is —O. and the others are hydrogen or OH; ...	10/17/2006
7115720	Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r...	10/03/2006
7112671	Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ...	09/26/2006
7109188	Methods and compositions for treating atheroma, tumors and other neoplastic tissue Injectible formulations comprising motexafin gadolinium are described herein. ...	09/19/2006
7097823	High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi...	08/29/2006
7094885	Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi...	08/22/2006
7087384	Rare earth metal cryptates which are not very sensitive to the fluorescence quenching The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates which are not very sensitive to this fluorescence quenching, said rare ea...	08/08/2006
7070759	High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi...	07/04/2006
7053210	Efficient synthesis of pyropheophorbide a and its derivatives A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, wit...	05/30/2006
7045116	Treatment of osteomyelitis with radiopharmaceuticals This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharm...	05/16/2006
7022843	β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins Improved β,β′-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compounds are provided as photosensitizers. Pharmaceutical compositions and photodynamic therapy comprising them are also disclosed. ...	04/04/2006
7018395	Photodynamic treatment of targeted cells The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent...	03/28/2006
7012089	[1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: where R1 through R7 are defined herein. The compounds of formula (I) are 5HT2c agonists or partial agonists, and...	03/14/2006
6962910	Supramolecular complexes as photoactivated DNA cleavage agents The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-meta...	11/08/2005
6946552	Refined routes to chlorin building blocks A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrah...	09/20/2005
6942966	Methods for processing chemical compounds having reactive functional groups Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or ...	09/13/2005
6887838	Bleach boosting components, compositions and laundry methods Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about 3 and mixtures thereof, bleaching species comprisi...	05/03/2005
6887868	Therapeutic 5-HT ligand compounds The present invention provides compounds of Formula (I): wherein: R1, R2, R3, R4, R5, R6 R7, R8, n, m, and X have any of the value...	05/03/2005
6878701	Potassium channel blocking agents Compounds of Formula I: wherein A and B are linking groups; R1, R2, R3 and R4 are defined moieties. An exemplary compound is: Th...	04/12/2005
6849619	Substituted pyridoindoles as serotonin agonists and antagonists The present invention is directed to certain novel compounds represented by structural Formula (I) or pharmaceutically acceptable salt forms thereof, wherein R1, R5, R6, R7, ...	02/01/2005
6828327	Macroheterocylic compounds useful as kinase inhibitors This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ...	12/07/2004

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Class 540/472 - Two of the cyclos share at least three ring members or a ring member is shared by three of the cyclos (e.g., bridged, peri-fused, etc., toxiferin)