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| Number | Title | Issue Date |
| 8173803 | Supramolecular scaffolds and methods of making the same Tribenzo-1,4,7-triazacyclononane and derivatives thereof having a formula (I) are disclosed. Methods of making tribenzo-1,4,7-triazacyclononane and related compounds also are disclosed. ... | 05/08/2012 |
| 7767810 | Macrocyclic modules comprising linked cyclic synthon units for use in the formation of selectively permeable membranes Certain macrocyclic modules comprising 3-24 synthons are provided herein. Each synthon is independently selected from cyclic substituents, wherein each synthon selected is bonded to the next through a linker to form a closed ring that defines a pore. One or more lip... | 08/03/2010 |
| 7750149 | Seven-membered heterocyclic carbenes and their metal complexes Disclosed are carbenes of the general formula: and including salts thereof, and metal complexes thereof. The carbenes are useful in any reaction where carbenes and carbene-metal complexes are used. The carbenes disclosed he... | 07/06/2010 |
| 7737272 | Diazaphosphacycle transition metal complexes Transition metal complexes include a diazaphosphacycle of formula III and a transition metal. The phosphorus atom of the diazaphosphacycle is bonded to the transition metal and the diazaphosphacycle of formula III has the following structure | 06/15/2010 |
| 7687620 | [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R1 through R7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial agonists, and are use... | 03/30/2010 |
| 7674899 | Dimeric azacyclic compounds and their use This invention relates to novel azacyclic derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system... | 03/09/2010 |
| 7432371 | Nanofilm and membrane compositions Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a subs... | 10/07/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7309699 | 3-Quinuclidinyl amino-substituted biaryl derivatives Compounds of formula (I) wherein A is N or N+—O−; n is 0, 1, or 2; Y is O, S, —NH—, and —N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6-membe... | 12/18/2007 |
| 7244843 | Modulators of serotonin receptors The present invention provides modulators of serotonin receptors, pharmaceutical compositions containing such modulators and methods for treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metab... | 07/17/2007 |
| 7241773 | 3-quinuclidinyl heteroatom bridged biaryl derivatives Compounds of formula: or pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, wherein: A and G are each independently N or N+—O−; m and n are each independently 0, 1, ... | 07/10/2007 |
| 7238771 | Dibenzodiazocine polymers Dibenzodiazocine polymers, methods for producing dibenzodiazocine polymers, products formed from dibenzodiazocine polymers, and uses for such dibenzodiazocine polymers are provided. ... | 07/03/2007 |
| 7238461 | Optical information-recording medium, novel oxonol compound and method of recording information An optical information-recording medium which contains a dye having at least two chromophores bonded to each other without any conjugated bond intervening between those chromophores. ... | 07/03/2007 |
| 7214538 | Device and method for the determination of lithium ion concentration in a biological fluid The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of ... | 05/08/2007 |
| 7005430 | Fused purine derivatives A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a sub... | 02/28/2006 |
| 6939963 | Method for the preparation of selectively-substituted corroles and new substituted corroles Corroles of formula I, wherein Ar is aryl or heteroaryl; M is absent or is a metal selected from Al, Ga, Co, Mn, Fe, Ru, Sn, Cr or Rh; E2, E3 and E17, the same or different, each is H, SO2Cl, SO3H, SO2 | 09/06/2005 |
| 6800656 | Tricyclic compounds and method of treating herpes virus The present invention provides a compound of the formula and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. Wherein: X=O, (CH2)m, S, ... | 10/05/2004 |
| 6743785 | Agents and methods for the treatment of proliferative diseases The present invention provides selective kinase inhibitors of formula (I). ... | 06/01/2004 |
| 6730666 | Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives Tertrapyrrolic macrocycles selected from 5,10,15,20-tetraaryl-porphyrins and 5,10,15-triaryl-corrloes, wherein said aryl radical is a carboaryl, a heteroaryl or a mixed carboaryl-heteroaryl radical and at least two of said aryl radicals are positively charged, inhib... | 05/04/2004 |
| 6624187 | Long wave length absorbing bacteriochlorin alkyl ether analogs Novel compounds that either preferentially absorb into hyperproliferative tissue and absorb light efficiently at a wavelength of between about 700 and about 850 nm or act as intermediates for such absorbing compounds. More particularly, the compounds of t... | 09/23/2003 |
| 6576760 | Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the polyamines except two being fully substituted and the remaining t... | 06/10/2003 |
| 6541628 | Process for the preparation of corroles and several such new compounds, including chiral derivatives, and the use thereof A new process for the preparation of corroles, having the structure of formula I below relies on a solvent-free condensation of an aldehyde with a pyrrole. Further disclosed are several new corroles, salts, optically active isomers and complexes thereof s... | 04/01/2003 |
| 6444808 | Methods of making cross-bridged macropolycycles Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.... | 09/03/2002 |
| 6410534 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 06/25/2002 |
| 6380180 | Potassium channel blocking agents This invention relates to novel potassium channel blocking agents, and their use in the preparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorde... | 04/30/2002 |
| 6306847 | Condensed purine derivatives The present invention provides condensed purine derivatives or pharmacologically acceptable salts thereof exhibiting adenosine A3 acceptor antagonising activity, and having an antiasthmatic action, a bronchodilator action, an antiantiitching ac... | 10/23/2001 |
| 6271251 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof A substituted guanidine derivative represented by the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton (Na | 08/07/2001 |
| 6225464 | Methods of making cross-bridged macropolycycles Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.... | 05/01/2001 |
| 6177551 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent oth... | 01/23/2001 |
| 6057440 | Process for preparing bis-indoly macrocycles This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## wherein R1, R2, X, W, and Y are as defined in the specification. The invention further provides the preparation, pharmaceutical ... | 05/02/2000 |
| 6020485 | Process for producing tetraazabicyclo monoacetic acid The present invention relates to the novel compound, 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one of formula (I), its preparation and the use thereof for the preparation of tetraazamacrocycles. ##STR1##... | 02/01/2000 |
| 5985869 | Benzoheterocyclic compounds Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy,... | 11/16/1999 |
| 5985871 | Benzoxazine compounds for enhancing synaptic response Compounds having a certain benzoxazine ring system and their precursors are disclosed which are useful for enhancing synaptic responses mediated by AMPA receptors. Also disclosed are methods for preparing such compounds, and methods for their use in treat... | 11/16/1999 |
| 5853699 | Use of tetra azacycle complexes as x-ray diagnostic agents for the liver and gallbladder The disclosed metal complexes are suitable as contrast media for computer tomography of the liver and the biliary tracts.... | 12/29/1998 |
| 5821365 | Process for preparing bis-indolyl macrocycles This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## wherein R1, R2, X, W, and Y are as defined in the specification. The invention further provides the preparation, pharmaceutical ... | 10/13/1998 |
| 5786352 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.C | 07/28/1998 |
| 5750518 | Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them... | 05/12/1998 |
| 5739322 | Process for preparing BIS-indolyl macrocycles This invention provides novel bis-indolemaleimide macrocycle derivatives of the formula: ##STR1## wherein R1, R2, X, W, and Y are as defined in the specification. The invention further provides the preparation, pharmaceutical formulations and th... | 04/14/1998 |
| 5733924 | DC 107 derivatives and treatment methods DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, wherein R1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrah... | 03/31/1998 |
| 5731299 | Phosphonosulfonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism The present invention relates to phosphonsulfonates and the pharmaceutically-acceptable salts and esters thereof, having the following structure according to formula (I): ##STR1## The present invention further relates to pharmaceutical compositions ... | 03/24/1998 |
