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| Number | Title | Issue Date |
| 7332149 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient... | 02/19/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7312225 | Macrocyclic pyrimidines, their production and use as pharmaceutical agents Macrocyclic pyrimidine derivatives of general formula I in which R1 to R5, X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent ... | 12/25/2007 |
| 7309567 | Method for reducing fluorescence quenching in bioassays The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized in that a fluorescent conjugate comprising an oligonucleotide bonded... | 12/18/2007 |
| 7301020 | Macrolide analogs and methods for identifying same Macrolide analogs and methods for identifying macrolide analogs capable of unregulated inhibition of actin filament dynamics are provided. A method according to the invention includes the steps of: (a) contacting F-actin with a candidate compound; and (b) assaying t... | 11/27/2007 |
| 7214538 | Device and method for the determination of lithium ion concentration in a biological fluid The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of ... | 05/08/2007 |
| 7211438 | Method and apparatus for predicting the presence of haemostatic dysfunction in a patient sample Methods for predicting the presence of haemostatic dysfunction in a patient from a time-dependent measurement profile include performing a time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent ... | 05/01/2007 |
| 7105672 | Cyclometallated catalysts A catalyst compound of formula I or II: (wherein R1–R11, M, E, T, X, Y, m and n are defined herein). The compound, when combined with a suitable activator, is active for the polymerization o... | 09/12/2006 |
| 7091338 | Purification of 4,4′(5′)- di-t-butylcyclohexano-18-crown-6 A purification method is disclosed for a predetermined water-insoluble extractant present in a liquid phase composition that additionally contains one or more additional extractants, synthesis reaction starting materials, and reaction byproducts dissolved as solutes... | 08/15/2006 |
| 7087384 | Rare earth metal cryptates which are not very sensitive to the fluorescence quenching The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates which are not very sensitive to this fluorescence quenching, said rare ea... | 08/08/2006 |
| 7030152 | Systematic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease The invention involves methods for characterizing an individual's risk profile of developing a future cardiovascular disorder by obtaining a level of the marker of systemic inflammation in the individual. The invention also involves methods for evaluating the likeli... | 04/18/2006 |
| 7014981 | Benzoindole styryl compounds and their uses in high-density recording media The invention discloses new benzoindole styryl compounds and its use for a high-density optical recording medium. The invention uses the dyes of the new benzoindole styryl compounds to form the recording layer of high-density recording media. The new benzoindole sty... | 03/21/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6962992 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reacti... | 11/08/2005 |
| 6946552 | Refined routes to chlorin building blocks A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrah... | 09/20/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6890922 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizi... | 05/10/2005 |
| 6869589 | Cryptate compounds and methods for diagnosis and therapy The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These functionalized derivatives are suitable for use in radiolabelling and simi... | 03/22/2005 |
| 6846802 | Macrocyclic NS3-serine protease inhibitors of hepatitis C virus comprising N-cyclic P2 moieties The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as... | 01/25/2005 |
| 6828327 | Macroheterocylic compounds useful as kinase inhibitors This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ... | 12/07/2004 |
| 6562823 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions co... | 05/13/2003 |
| 6559143 | Oxabispidine compounds useful in the treatment of cardiac arrhyythmias There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the trea... | 05/06/2003 |
| 6552187 | Process for the preparation of herbicidal derivatives ##STR1## A process for the preparation of compounds of formula (I), which process comprises reacting a compound of formula (II), in an inert organic solvent, optionally in the presence of a base, with a compound of formula (IV), (IVa) or (IVb), and option... | 04/22/2003 |
| 6534506 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 03/18/2003 |
| 6444824 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## and where m is 1 or 3-6; Q and Y are the same or differen... | 09/03/2002 |
| 6441164 | Wurster's crown ligands Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand by one or both of the amine nitro... | 08/27/2002 |
| 6413964 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds of the formula A: ##STR1## wherein W is a heterocycle, V is a heterocycle or aryl moiety and Z1 is a suitably substituted aryl or heterocycle moiety. The instant com... | 07/02/2002 |
| 6413963 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, su... | 07/02/2002 |
| 6410534 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 06/25/2002 |
| 6391900 | Cytotoxic tris(oxazole)-containing macrolides The present invention discloses new cytotoxic tris(oxazole)-containing macrolides having the formula: ##STR1## wherein X represents a lower alkyl; R1 and R2 represent hydrogen or lower alkyl; R3a represents hydrogen, and R... | 05/21/2002 |
| 6359130 | Bridged indenopyrrolocarbazoles The present invention is directed to novel fused aryl and heteroaryl bridged indenopyrrolocarbazoles which are useful, inter alia, as therapeutic agents. The invention is also directed to methods for making and using the bridged indenopyrrolocarbazoles.... | 03/19/2002 |
| 6329376 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compo... | 12/11/2001 |
| 6316436 | Inhibitors of prenyl-protein transferase The present invention is directed to compounds which inhibit prenyl-protein transferase and particularly, the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this in... | 11/13/2001 |
| 6294525 | Reverse-turn mimetics and methods relating thereto Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: ##STR1## wherein A, R1, R2, R2a,... | 09/25/2001 |
| 6291447 | Granulatimide compounds and uses thereof Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have the general formula: ##STR1## wherein are independently R or Z as defined below, or in combination F and F' is Ar1 as defined b... | 09/18/2001 |
| 6225306 | Biphenyl derivatives and drug composition A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: ##STR1## [In the formula (1), A represents a single bond, --CH2 --, --CO--, --CS-- or --SO2 --; B represents a sin... | 05/01/2001 |
| 6211359 | Triaza-cryptand and method of determining an alkali ion The invention relates to a triaza-cryptand of the general Formula I ##STR1## wherein a is selected from the group consisting of 0 and 1, b and c independently are selected from the group consisting of 0 and 1, with the proviso that not both of b and c are 0, d... | 04/03/2001 |
| 6177551 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent oth... | 01/23/2001 |
| 6156282 | Crown calix[4]arenes, method of preparation and use for selective extraction of caesium The invention relates to new calixarenes of formula: ##STR1## in which R1 represents a crown ether chain that includes at least two aryl or cycloalkyl rings, R2 is a hydroxyl or alkoxy group, or the two R2 groups together ... | 12/05/2000 |
