"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
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| Number | Title | Issue Date |
| 8003784 | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl... | 08/23/2011 |
| 7964721 | Ratiometric fluorescent chemosensor for selective detection of Hg (II) ions A mercury selective fluorescent chemosensor for detecting mercury ions by a compound represented by formula 1 and a novel fluorescent sensitive compound prepared by introducing two aminopyrene functions as a fluorescent sensitive moiety into a binding site of the co... | 06/21/2011 |
| 7432371 | Nanofilm and membrane compositions Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a subs... | 10/07/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7309567 | Method for reducing fluorescence quenching in bioassays The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized in that a fluorescent conjugate comprising an oligonucleotide bonded... | 12/18/2007 |
| 7279491 | Phenylpiperidines and phenylpyrrolidines Substituted phenylpiperidines and phenylpyrrolidines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 10/09/2007 |
| 7271154 | Antibiotic conjugates This invention features a compound of the following formula: wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently bonded to the antibi... | 09/18/2007 |
| 7214538 | Device and method for the determination of lithium ion concentration in a biological fluid The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of ... | 05/08/2007 |
| 7105531 | Tricyclic protein kinase inhibitors This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents. ... | 09/12/2006 |
| 7091196 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,... | 08/15/2006 |
| 7067659 | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, e.g., 1,5-bis(3-nitrooxypropyyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfus... | 06/27/2006 |
| 7067508 | Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a prepa... | 06/27/2006 |
| 7022717 | Chemokine receptor binding heterocyclic compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well... | 04/04/2006 |
| 6949537 | PI-3 kinase inhibitor prodrugs The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 09/27/2005 |
| 6936700 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hyd... | 08/30/2005 |
| 6887994 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon a... | 05/03/2005 |
| 6869589 | Cryptate compounds and methods for diagnosis and therapy The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These functionalized derivatives are suitable for use in radiolabelling and simi... | 03/22/2005 |
| 6849203 | Photoisomerizable compounds The invention relates to photoisomerizable compounds of formula I wherein A, Z, L, R, R1, k, m and r are defined herein. ... | 02/01/2005 |
| 6787522 | Antibacterial agents Compounds of formula (I) are antibacterials: wherein: R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 ... | 09/07/2004 |
| 6764996 | 9a-azalides with antibacterial activity Compounds of formula (I) formula (II) formula (III) and formula (IV) or pha... | 07/20/2004 |
| 6749988 | Amine compounds, resist compositions and patterning process Novel amine compounds having a nitrogen-containing cyclic structure and a hydrating group such as a hydroxy, ether, ester, carbonyl, carbonate group or lactone ring are useful for use in resist compositions for preventing a resist film from thinning and also for enh... | 06/15/2004 |
| 6667320 | Chemokine receptor binding heterocyclic compounds The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected ce... | 12/23/2003 |
| 6635637 | Cyclic oxyguanidine protease inhibitors Cyclic oxyguanidine compounds, including compounds of Formulae I and II: ##STR1## wherein R1, R3 -R6, R21 -R26, L, Y, Z, and A are set forth in the specification, as well as hydrates, solvates or phar... | 10/21/2003 |
| 6610697 | Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods This invention relates to a series of imidazopyrimidines of Formula I, ##STR1## and pharmaceutical compositions containing them. The compounds of the invention inhibit the production of a number of inflammatory cytokines and are useful in the treatment an... | 08/26/2003 |
| 6608048 | Tricyclic protein kinase inhibitors This invention provides compounds of Formula (I), ##STR1## where A", Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.... | 08/19/2003 |
| 6548509 | 3-aryl substituted pyrazolo[4,3-D]pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands This invention encompasses compounds of the formula ##STR1## wherein Ar represents a mono-, di- or trisubstituted aryl group where at least one position on Ar ortho to the point of attachment to the pyrazole ring is substituted; and R1 represen... | 04/15/2003 |
| 6545038 | Heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of... | 04/08/2003 |
| 6514298 | Fuel additive and fuel composition Fuel additives comprise a compound having a group represented by the formula >C.dbd.=N-- (1). Also disclosed are fuel compositions containing such additives. The additives have a superior detergent effect to conventional gasoline detergents and an excell... | 02/04/2003 |
| 6509334 | Cyclocarbamate derivatives as progesterone receptor modulators This invention provides compounds of Formula (I): ##STR1## wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 ... | 01/21/2003 |
| 6495686 | Pyrimido [4,5,b]indolizine derivatives and aza analogues thereof; CRF1 specific ligands Disclosed are compounds of the formula: ##STR1## wherein Ar, R1, R2, R3, W, X, Y, and Z are substituents as defined herein, which compounds are highly selective partial agonists or antagonists at human CRF1 rece... | 12/17/2002 |
| 6495688 | Deazapurine derivatives: a new class of CRF1 specific ligands Disclosed are compounds of formula ##STR1## wherein Ar represents an aryl or heteroaryl group; and R1, R2, R3, R4 and R5 represent organic or inorganic substituents, which compounds are highly selective pa... | 12/17/2002 |
| 6495681 | Local anesthetic compounds and uses Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linker... | 12/17/2002 |
| 6476016 | Cyclic oxyguanidine pyrazinones as protease inhibitors Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: ##STR1## wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, solvates or pharmaceutically ... | 11/05/2002 |
| 6462034 | Local anesthetic compounds and uses Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linker... | 10/08/2002 |
| 6452011 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## or ##STR3## and where m is 1 or 4-6; Q and Y are the... | 09/17/2002 |
| 6436919 | Local anesthetic compounds This invention is directed to novel local anesthetic compounds, pharmaceutical compositions containing these compounds, methods of use and methods of preparing these compounds. In one embodiment, the compounds are of the following formula: ##STR1## w... | 08/20/2002 |
| 6433124 | Reactive polymers and isocyanate-reactive polymers obtainable therefrom In a compound of the formula I ##STR1## (reactive polymer), L is a, polymer, XY is a reactive radical which is inert toward NCO groups and splits off one or more protective groups Y under acidic, neutral or basic conditions and the radical X bears, after ... | 08/13/2002 |
| 6417353 | Preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing coppe... | 07/09/2002 |
| 6384026 | Macrocyclic polyamine lactones and derivatives thereof and their use as arthropod repellents The present invention describes an isolated macrocycle having the formula: ##STR1## where d is an integer from 0 to about 100; A, B, and each D are the same or different and are selected from the group consisting of ##STR2## each R1 is the same... | 05/07/2002 |
| 6372733 | Hexahydro-5-imino-1,4-1,4-thiazepine derivatives as inhibitors of nitric oxide synthases Disclosed herein are compounds of Formula I ##STR1## and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of ... | 04/16/2002 |