Class 540/466 - Spiro

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which include a spiro ring system.
No. of patents: 64
Last issue date: 03/08/2011

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Number	Title	Issue Date
7902354	Lapachone compounds and methods of use thereof The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphtho...	03/08/2011
7417040	Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 Disclosed are fused tricyclic compounds of the following formula I, or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof. The disclosed compounds are useful as inhibitors of 17β-hydroxysteri...	08/26/2008
7410969	Antitumoral analogs of ET-743 Antitumor compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or d...	08/12/2008
7329746	Macrocyclic beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to compounds of formula I which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is...	02/12/2008
7323455	7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ...	01/29/2008
7311970	Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti...	12/25/2007
7247629	Antitumoral analogs of et-743 Antitumour compounds have the five membered fused ring ecteinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or ...	07/24/2007
7241892	Hemisynthetic method and new compounds Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically: R1 is an amidomethylene group or an acyloxymethylene group...	07/10/2007
7148214	Antihistaminic spiro compounds This invention concerns the compounds of formula or a prodrug, a N-oxide, an addition salt, a quaternary amine or a stereochemically isomeric form thereof wherein R1, R2, —A—B—, L, and n hav...	12/12/2006
7145003	Process for synthesizing 1,5 dinosyl-3,3,7,7-tetrakis(difluoramino)octahydro-1,5-diazocine (DNTDFD) A process for synthesizing 1,5-Dinosyl-3,3,7,7-tetrakis(difluoramino) octahydro-1,5-diazocine (DNTDFD) by reacting tetrahydro-1,5-bis(4-nitrobenzenesulfonyl)-1,5-diazocine-3,7-(2H, 6H) dione with HNF2/oleum initially approximately between −5 and 0 degrees C., and ...	12/05/2006
7122549	Saframycins, analogues and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. ...	10/17/2006
7122677	NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5...	10/17/2006
7122662	Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e...	10/17/2006
7012043	Drilling fluids Drilling fluid additives that act to control clay swelling in drilled formations without adversely effecting the properties of the drilling fluid. The drilling fluid additives preferably comprise a polyether amine, a polyether amine derivative, or mixtures thereof. ...	03/14/2006
6793960	Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionally bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portio...	09/21/2004
6630475	Adenosine A2a receptor antagonists Compounds having the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or --C(O)CH2 --; Y is --N(R2)CH2 CH...	10/07/2003
6545038	Heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of...	04/08/2003
6509334	Cyclocarbamate derivatives as progesterone receptor modulators This invention provides compounds of Formula (I): ##STR1## wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 ...	01/21/2003
6444819	Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R1, R2 and R3 independently represent organic or inorganic subs...	09/03/2002
6417355	Geminal-dinitro-1-5 diazocine derivatives This invention involves a new class of compounds, certain geminal-dinitro-substituted heterocycles, including geminal-bis(difluoramino)-substituted heterocyclic nitramines and the production thereof. More specifically, this invention involves the pro...	07/09/2002
6372733	Hexahydro-5-imino-1,4-1,4-thiazepine derivatives as inhibitors of nitric oxide synthases Disclosed herein are compounds of Formula I ##STR1## and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of ...	04/16/2002
6207668	Substituted pyridines/pyrimidines, their preparation, and their use as pesticides The present invention relates to novel substituted pyridines/pyrimidines of the formula I ##STR1## where A is CH or N; X is NH, oxygen or S(O)q where q is 0, 1 or 2; Y is a direct bond or CH2 ; Z is oxygen, NR7 or S(O)	03/27/2001
6174940	Synergistic stabilizer mixture based on polyalkyl-1-oxa-diazaspirodecane compounds The present invention relates to mixtures comprising the compound I in a proportion of 65-95% by weight, the compound II in a proportion of 5-35% by weight and the compound III in a proportion of 0-10% by weight ##STR1## wherein the substituents are as de...	01/16/2001
6124293	Semi-synthetic ecteinascidins The present invention is directed to several newly prepared semi-synthetic ecteinascidin (Et) species, designated herein as Et 757, Boc-Et 729, Iso-Et 743, Et 875, and Et 1560. The physical properties of these compounds, their preparation and bioactivitie...	09/26/2000
6084093	Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4	07/04/2000
5952354	Tris carbamic acid esters: inhibitors of cholesterol absorption Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are therefore implicated in the inhibition of absorption of cholester...	09/14/1999
5922748	Indole derivatives as 5-HT agonists Compounds of formula (I) ##STR1## wherein R and R1 are hydrogen, C1-4 alkyl or are linked to form a ring, A is a cycloalkyl or alkyl-cycloalkyl group, n is an integer from 0 to 3, W is an optionally substituted 5-or 6-membered hetero...	07/13/1999
5833885	Photochromic compounds A spiro (indolino) oxazine compound of general formula (I) ##STR1## wherein R1 represents a group of the formula --NR2 R3 wherein each of R2 and R3, which may be the same or different, independen...	11/10/1998
5721362	Process for producing ecteinascidin compounds The present invention is directed to a synthetic process for the formation of ecteinascidin compounds and related structures, such as the saframycins. In one particularly preferred embodiment, the present invention provides a synthetic route for the forma...	02/24/1998
5654426	Ecteinascidins Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts...	08/05/1997
5633378	Polyalkylpiperidine compounds Polyalkylpiperidine compounds of the formula I ##STR1## in which Y is the group ##STR2## are very effective stabilizers for organic materials....	05/27/1997
5587479	Basic derivatives of glutamic acid and aspartic acid as gastrin or cholecystokinin antagonists Compounds of general formula (I), in which r is 1 or 2, R1 is selected independently from: unsubstituted, mono- or di-substituted phenyl groups, unsubstituted, mono- or di-substituted phenylamino groups, the 2(beta)-naphthyl group, and heterocy...	12/24/1996
5550234	Polyalkylpiperidine compounds Polyalkylpiperidine compounds of the formula I ##STR1## in which Y is one of the groups ##STR2## are distinguished by very low volatility at elevated temperature and are very effective stabilizers for organic substances....	08/27/1996
5478932	Ecteinascidins Ecteinascidins (Et's), isolated from the Caribbean tunicate Ecteinascidia turbinata, protect mice in vivo against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and the LX-1 human lung and MX-1 human mammary carcinoma zenografts...	12/26/1995
5399709	N-substituted triarylmethane sulfonamides and method of preparation A novel class of N-substituted triarylmethane sulfonamides is provided which undergo reversible oxidation into colored form and reversible reduction of the oxidized form into colorless form. The N-substituted triarylmethane sulfonamides can be represented...	03/21/1995
5252567	Diazine derivatives This invention concerns compounds of the formula I: ##STR1## wherein R1 is (1-10C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-4C)-alkyl, phenyl or phenyl(1-4C)alkyl, the phenyl moiety of the latter two optionally bearing one or more subst...	10/12/1993
5149804	Ecteinascidins 736 and 722 Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro-ଲ-carboline-substituted bis(tetrahydro- isoquinolines) related to the previous...	09/22/1992
5142054	Optically pure 1,3-dioxenones, methods for preparing same and use thereof Disclosed are new 1,3-dioxenones having the formulae ##STR1## in an optically pure state, a process for preparing same and the use thereof....	08/25/1992
5128436	Cyclic polyhydroxy polyether oligomers having spirodilactam units Novel cyclic oligomers contain moieties of 2-hydroxyl-1,3-propylene alternating with moieties of 1,6-di(oxyphenyl) 1,6-diaza [4.4] spirodilactam and, optionally, di(oxyphenyl) compound. The oligomers are thermoplastic resin of the phenoxy resin type....	07/07/1992
5089273	Ecteinascidins 729, 743, 745, 759A, 759B and 770 The present invention relates to novel compositions of matter extracted from the well-known and readily available tropical marine invertebrate, Ecteinascidia turbinata, and designated herein as ecteinascidins 729, 743, 745, 759A, 759B and 770. These compo...	02/18/1992

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Class 540/466 - Spiro