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| Number | Title | Issue Date |
| 8153784 | Imaging of enzyme activity This invention relates to biochemistry and magnetic resonance imaging. ... | 04/10/2012 |
| 7989617 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula: ... | 08/02/2011 |
| 7579463 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula: ... | 08/25/2009 |
| 7385054 | Trimeric, macrocyclically substituted halo-benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media. ... | 06/10/2008 |
| 7368100 | Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same Backbone-substituted 1,4,7,10-tetraaza cyclododecane-N,N′,N″,N′″-tetraacetic acid compounds, metal complexes thereof, compositions thereof, conjugates thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 05/06/2008 |
| 7357881 | Cycloamide-transition metal complexes and bleach catalysts The invention provides a bleaching catalyst and a bleaching composition having a sufficient bleaching effect even at low temperatures and being excellent in an effect of preventing color migration in fibers with less bleach of dyes and less damage to fibers. The inv... | 04/15/2008 |
| 7351389 | Aminocarboxylate ligands having substituted aromatic amide moieties Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R13, A1, R1 and R2 are as... | 04/01/2008 |
| 7335629 | Support-fixed bleaching catalyst complex compounds suitable as catalysts for peroxygen compounds The present invention relates to support-fixed bleaching catalyst(s)suitable or the catalysis of peroxide compounds, characterized in that the support-fixed bleaching catalyst(s) is/are covalently bonded to a support by means of at least one organic ligand of the bl... | 02/26/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7291727 | Light-harvesting discotic liquid crystalline porphyrins and metal complexes Novel discotic liquid crystalline porphyrins and discotic liquid crystalline metal complexes, methods for their preparation, and device fabrication are disclosed. Materials with partially perfluorinated alkyl group in the peripheral chains show a strong tendency tow... | 11/06/2007 |
| 7239792 | Backlight unit having optical reflector A backlight unit is disclosed, in which the light is concentrated when the light is incident on a light-guiding plate so as to improve light efficiency and color realization ratio. The backlight unit includes a light source emitting light; and optical fiber surround... | 07/03/2007 |
| 7211241 | Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes Described are new cascade polymer complexes, compositions containing them and use of the complexes in diagnosis and therapy, particularly for magnetic resonance imaging and computer tomography imaging. ... | 05/01/2007 |
| 7208140 | Trimeric macrocyclic substituted benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine and A1 and A2 have different meanings, are suitable as contrast media. ... | 04/24/2007 |
| 7160873 | Texaphyrin coordination compounds and uses thereof Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed. ... | 01/09/2007 |
| 7161000 | Method for producing phenol condensate Provided is a method for producing a phenol condensate by oxidative condensation of a phenol compound not having a substituted group on at least one ortho-position, in the presence of a specific complex (II) and oxygen, wherein a condensate coupled at para-position ... | 01/09/2007 |
| 7148174 | Non-metallocene catalyst system The present invention describes a novel group of specific transition metal compounds, referred to as nonmetallocene compounds, and catalyst systems prepared therefrom. These catalyst systems which have become obtainable for the first time are suitable for the polyme... | 12/12/2006 |
| 7129346 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers may be substituted by a dye moiety, a chemical... | 10/31/2006 |
| 7122537 | Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases This invention provides antioxidant cyclic salen-metal compounds, compositions of such antioxidant cyclic salen-metal compounds having superoxide activity, catalase activity and/or peroxidase activity and methods of using such antioxidant cyclic salen-metal composit... | 10/17/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7115549 | Composition comprising macrocyclic tetra-amido metal complex as bleaching catalyst The present invention provides a laundry bleaching composition comprising: a) a macrocycilc tetra amido N-donor metal-ligand complex (preferably, 5,6-benzo-3,8,11,13-tetraoxo-2,2,9,9,12,12-hexamethyl-1,4,7,10-tetraaza-cyclo-tridecane), and b) an alkyl benzene sulpho... | 10/03/2006 |
| 7112671 | Non-symmetric tripyrranes in the synthesis of novel macrocycles The present invention provides certain non-symmetric tripyrranes; that is, tripyrranes that do not contain a mirror plane of symmetry perpendicular to the plane containing the tripyrrane. Further, the invention includes texaphyrin compounds and sapphyrin compounds, ... | 09/26/2006 |
| 7109188 | Methods and compositions for treating atheroma, tumors and other neoplastic tissue Injectible formulations comprising motexafin gadolinium are described herein. ... | 09/19/2006 |
| 7097823 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/29/2006 |
| 7094885 | Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/22/2006 |
| 7070759 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 07/04/2006 |
| 7060248 | Matrix metalloproteinase inhibitors Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety i... | 06/13/2006 |
| 7026415 | Clathrochelates as olefin polymerization catalyst components Catalyst systems and methods for olefin polymerization are disclosed. The polymerizations are performed in the presence of a clathrochelate which comprises a transition metal ion and an encapsulating macropolycyclic ligand. At least one of the capping atoms of the m... | 04/11/2006 |
| 7012140 | Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the tetraazacyclododecane ligand. Pendent arms R, R′, R″ and R′″ attach... | 03/14/2006 |
| 7008613 | Quaternary ammonium compounds A compound of formula corresponding to either formula (Ia) or (Ib): wherein: M represents a molecule that can be used for the treatment or diagnosis of pathologies caused by attack on the cartilage, ... | 03/07/2006 |
| 6974567 | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, coronary artery disease, renal disease, thrombosis, transient isc... | 12/13/2005 |
| 6946552 | Refined routes to chlorin building blocks A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing the tetrahydrobilene to form a chlorin. Intermediates including tetrah... | 09/20/2005 |
| 6919327 | Texaphyrin coordination compounds and uses thereof Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed. ... | 07/19/2005 |
| 6916799 | Substituted porphyrins The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also... | 07/12/2005 |
| 6916460 | Macrocyclic chelants for metallopharmaceuticals This invention relates to macrocyclic chelants comprised of one or two heteroatom-containing bridges, compositions containing them and their use in medicine, particularly in diagnostic imaging and radiotherapy. This invention relates especially to the use of metal c... | 07/12/2005 |
| 6906189 | Catalysts and methods for catalytic oxidation Catalytic systems and methods for oxidizing materials in the presence of metal catalysts (preferably manganese-containing catalysts) complexed with selected macropolycyclic rigid ligands, preferably cross-bridged macropolycyclic ligands. Included are using these met... | 06/14/2005 |
| 6906050 | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis Substituted porphyrin and azaporphyrin deviations with various substitutents in the 12- and 17-positions of the porphyrin skeleton as pharmaceutical agents for use in photodynamic therapy, MRI diagnosis, and radiodiagnostics. ... | 06/14/2005 |
| 6902891 | Process for labeling a nucleic acid A process of fragmenting and labeling a synthetic or natural nucleic acid, comprising the steps of providing a mixture containing a nucleic acid, a labeling agent containing a detectable label, and at least one multivalent metal cation in a substantially aqueous sol... | 06/07/2005 |
| 6893564 | Shaped bodies containing metal-organic frameworks The present invention relates to a novel class of shaped bodies containing metal-organic frameworks. Said metal-organic frameworks comprise at least one metal ion and at least one at least bidentate organic compound and contain at least one type of micro- and mesopo... | 05/17/2005 |
| 6869589 | Cryptate compounds and methods for diagnosis and therapy The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These functionalized derivatives are suitable for use in radiolabelling and simi... | 03/22/2005 |
| 6828439 | Compounds, composition, and methods for photodynamic therapy Disclosed are novel compounds, compositions, and methods that are particularly useful in photodynamic therapy. In particular, the inventive compounds, compositions, and methods relate to the formation of cytotoxic radical species in the presence of light. Significan... | 12/07/2004 |
