Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7432088 | Methods for the production of ansamitocins A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins. ... | 10/07/2008 |
| 7375217 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 05/20/2008 |
| 7361647 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 04/22/2008 |
| 7317100 | Epothilone derivatives The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation. ... | 01/08/2008 |
| 7282493 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 10/16/2007 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 7176235 | Epothilone derivatives and methods for making and using the same This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar... | 02/13/2007 |
| 7153879 | Polymorphs of an epothilone analog There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula ... | 12/26/2006 |
| 7125893 | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R... | 10/24/2006 |
| RE39356 | Process for the preparation of epothilone analogs The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction ... | 10/17/2006 |
| RE39251 | Polymorphs of an epothilone analog There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are... | 08/29/2006 |
| 6982276 | Polymorphs of an epothilone analog There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also p... | 01/03/2006 |
| 6965034 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates ... | 11/15/2005 |
| 6930102 | 16-halogen-epothilone derivatives, process for their production, and their pharmaceutical use A compund of formula I, an epothilone derivative, its method of preparation, and use as a pharmaceutical agent in treating malignant tumors ... | 08/16/2005 |
| 6921769 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions com... | 07/26/2005 |
| 6913748 | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs Disclosed is a method of making conjugates of cell binding agents and small molecule drugs comprising reacting a cell binding agent with a bifunctional cross-linking moiety to thereby provide the cell binding agent with a reactive disulfide group and then reacting t... | 07/05/2005 |
| 6790954 | Mutant Actinosynnema pretiosum strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 09/14/2004 |
| 6716821 | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same Cytotoxic agents bearing a polyethylene glycol (PEG) linking group having a terminal active ester, cytotoxic conjugates comprising one or more cytotoxic agents linked to a cell-binding agent via PEG linking groups, and methods for producing both are disclosed. A the... | 04/06/2004 |
| 6689802 | Polymorphs of an epothilone analog There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula ##STR1## Also provided are methods of formi... | 02/10/2004 |
| 6656711 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothil... | 12/02/2003 |
| 6605599 | Epothilone derivatives The present invention relates to epothilone derivatives, having the following formula ##STR1## in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1 -R7 are as defined herein, method... | 08/12/2003 |
| 6518421 | Process for the preparation of epothilone analogs The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a singl... | 02/11/2003 |
| 6489314 | Epothilone derivatives and methods for making and using the same The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula ##STR1## are provided wherein: R1, R2, R3, and R5 are each independently hydrogen, ... | 12/03/2002 |
| 6441163 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibod... | 08/27/2002 |
| 5416064 | Cytotoxic agents comprising maytansinoids and their therapeutic use A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a phar... | 05/16/1995 |
| 5300495 | Indole antiinsectan metabolites Sulpinine C, secopenitrem B and 10-oxo-11,33-dihydropenitrem B indole compounds have been isolated from the sclerotia of the fungi Aspergillus sulphureus. Aflatrem B has been isolated from the sclerotia of the fungi Aspergillus flavus, and 14-hydroxypaspa... | 04/05/1994 |
| 5227396 | Indole antiinsectan metabolites Sulpinine C, secopenitrem B and 10-oxo-11,33-dihydropenitrem B indole compounds have been isolated from the sclerotia of the fungi Aspergillus sulphureus. Aflatrem B has been isolated from the sclerotia of the fungi Aspergillus flavus, and 14-hydroxypaspa... | 07/13/1993 |
| 5208020 | Cytotoxic agents comprising maytansinoids and their therapeutic use A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a phar... | 05/04/1993 |
| 5130326 | Sulpinine, secopenitrem B and aflatrem B antiinsectan metabolites Indole compounds named "sulphinine" and "secopenitrem" have been isolated from the sclerotia of from fungi Aspergillus sulphureus. An indole compound named "aflatrem B" has been isolated from the sclerotia of the fungi Aspergillus flavus. The compounds ar... | 07/14/1992 |
| 5059618 | Novel bioactive discodermides and methods of use A novel lactam discodermide has been isolated from a marine sponge. This compound, and its derivatives, are useful as antifungal and antitumor agents.... | 10/22/1991 |
| 4424219 | 9-Thiomaytansinoids and their pharmaceutical compositions and use This invention relates to 9-thiomaytansinoid compounds represented by the formula ##STR1## wherein R is hydrogen or acyl derived from a carboxylic acid, X is chlorine or hydrogen, Y is hydrogen, lower alkylsulfonyl, or alkyl or aralkyl which are... | 01/03/1984 |
| 4418064 | Chemotherapeutically active maytansinoids: treflorine, trenudine, and N-methyltrenudone A novel group of maytansinoid compounds has been discovered in the seed tissue of Trewia nudiflora. They are represented by the general formula ##STR1## and are uniquely characterized by a 12-membered ring joining C-3 and the amide nitrogen at C-18, ... | 11/29/1983 |
| 4364866 | Maytansinoids Antibiotic C-15003 PHO of the formula: ##STR1## wherein R1 is H, hydroxyl, alkanoyloxy, alkenylcarbonyloxy or arylcarbonyloxy; R2 is H, hydroxyl or alkanoyloxy; R3 is H or alkanoyloxy is produced by introducing a hydr... | 12/21/1982 |
| 4362663 | Maytansinoid compound Antibiotic C-15003 PND of the formula: ##STR1## wherein R is H or alkanoyl containing not more than 5 carbon atoms is produced by contacting a maytansinoid compound with a culture broth, inclusive of a processed matter derived therefrom, of a microor... | 12/07/1982 |
| 4360462 | Process for preparing maytansinol A novel Antibiotic C-15003 is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-15003 is useful as an antifungal agent or an antiprotozoan agent.... | 11/23/1982 |
| 4331598 | Maytansinoids Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained ... | 05/25/1982 |
| 4322348 | Maytansinoids Novel Antibiotic C-15003PND, which has the formula: ##STR1## wherein R represents hydrogen, --CO--CH3, --CO--CH2 --CH3, ##STR2## is produced by cultivating a microorganism of the genus Nocardia. The Antibiotic C-... | 03/30/1982 |
| 4317821 | Maytansinoids, their use and pharmaceutical compositions thereof Novel maytansinoids of the formula: ##STR1## wherein Y is H or Cl, and R is C2-15 alkyl, phenyl-C1-4 alkyl, pyridyl-C1-4 alkyl, imidazolyl-C1-4 alkyl, indolyl-C1-4 alkyl, furyl-C1-4 al... | 03/02/1982 |
