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| Number | Title | Issue Date |
| 8106187 | Process for the preparation of a macrocycle The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing ... | 01/31/2012 |
| 8034927 | Macrocyclic dyes having naphthyl moieties Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-... | 10/11/2011 |
| 8012939 | Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers thereof, wherein each variable has specific definitions. Pharmaceutical compositions containing compounds (I) and process for preparing... | 09/06/2011 |
| 8008251 | Macrocyclic inhibitors of hepatitis C virus Inhibitors of HCV of formula (I). and the N-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; R1 is hydrogen or C1-6alkyl; R | 08/30/2011 |
| 7910728 | Process for the preparation of a macrocycle The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing ... | 03/22/2011 |
| 7875713 | Synthetic binding pairs comprising cucurbituril derivatives and polyammonium compounds and uses thereof Derivatized cucurbiturils and cucurbituril assemblies formed thereby are disclosed. Also disclosed are binding pairs of the disclosed cucurbituril assemblies and polyamine structures, which are highly advantageous over the presently known affinity pairs and therefor... | 01/25/2011 |
| 7829698 | Nano-particles comprising cucurbituril derivatives, pharmaceutical composition containing the same, and process for the preparation thereof Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereo... | 11/09/2010 |
| 7544798 | Process for preparing macrocyclic compounds Disclosed is a multi-step process for preparing a macrocyclic compound of the formula (I): wherein Q is a radical of the following formula: and the other variables are as defined ... | 06/09/2009 |
| 7442558 | Phthalamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention ... | 10/28/2008 |
| 7432371 | Nanofilm and membrane compositions Nanofilms useful for filtration are prepared from oriented amphiphilic molecules and oriented macrocyclic modules. The amphiphilic species may be oriented on an interface or surface. The nanofilm may be prepared by depositing or attaching an oriented layer to a subs... | 10/07/2008 |
| 7432088 | Methods for the production of ansamitocins A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins. ... | 10/07/2008 |
| 7429565 | Antiviral phosphonate analogs The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing su... | 09/30/2008 |
| 7404912 | Salicylamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the inventio... | 07/29/2008 |
| 7378411 | Substituted thienopyrimidinones as a mitotic kinesin inhibitor The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which ... | 05/27/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7354922 | Bridged ring NKantagonists A compound having the general structure shown in Formula (I): or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example vari... | 04/08/2008 |
| 7312225 | Macrocyclic pyrimidines, their production and use as pharmaceutical agents Macrocyclic pyrimidine derivatives of general formula I in which R1 to R5, X, Y, A, B, m and n have the meanings that are contained in the description, as inhibitors of the cyclin-dependent ... | 12/25/2007 |
| 7279582 | Retroviral protease inhibiting compounds A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed. ... | 10/09/2007 |
| 7268211 | Removal of ruthenium by-product by supercritical fluid processing A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: w... | 09/11/2007 |
| 7262186 | Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which ... | 08/28/2007 |
| 7262187 | Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor The present invention relates to azolopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which c... | 08/28/2007 |
| 7253160 | Depeptidized inhibitors of hepatitis C virus NS3 protease The present invention discloses novel depeptidized compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. ... | 08/07/2007 |
| 7244723 | Substituted furopyrimidinones as a mitotic kinesin inhibitors The present invention relates to furanopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which ... | 07/17/2007 |
| 7230021 | Potent, simplified derivatives of pateamine A The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim 1. The present invention also provides processes for the prep... | 06/12/2007 |
| 7214715 | Compounds to treat Alzheimer's disease The present invention is substituted amines of formula (X) and of the formula (X′) useful in treating Alzheimer's disease and other similar diseases. ... | 05/08/2007 |
| 7211572 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt th... | 05/01/2007 |
| 7208595 | Peptide deformylase inhibitors as novel antibiotics A macrocyclic peptide deformylase (PDF) inhibitor comprising a peptide or peptide mimetic having three residues, P1′, P2′, and P3′, wherein P2′ connects P1′ and P3′, wherein P1′ and P3′ each have a side chain, and wherein the side chains on P1′ and... | 04/24/2007 |
| 7192949 | Substituted bicyclic pyrimidinones as a mitotic kinesin KSP inhibitors The present invention relates to cycloalkylpyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions wh... | 03/20/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 7189844 | Ring-closing metathesis process in supercritical fluid Disclosed is a process for preparing a compound of formula I comprising cyclizing a diene compound of formula III in the presence of a ruthenium catalyst in a suitable organic solvent, wherein the process is performed in a gaseous fluid at supercritical or near-supe... | 03/13/2007 |
| 7186828 | Cyclic urea compounds and preparation thereof A method for preparing cyclic urea compounds from at least an activated carbamic acid derivative containing an unprotected primary or secondary amine function, includes a cyclization step which consists in a reaction between the primary or secondary amine function a... | 03/06/2007 |
| 7183374 | Method of removing transition metals A process for diminishing the concentration of a metal complex from a solution containing said complex by the addition of an optionally fused and/or optionally substituted heterocyclic compound. The added compound is a solubility-enhancing compound that enhances the... | 02/27/2007 |
| 7179908 | Water-and organic-soluble cucurbituril derivatives, their preparation methods, their separation methods and uses Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: where X is O, S or NH; R1 and R2 are each independently selected from the group consisting o... | 02/20/2007 |
| 7176208 | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C v... | 02/13/2007 |
| 7163935 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 01/16/2007 |
| 7160466 | Uses of cucurbituril devices Uses of cucurbituril derivatives are disclosed. The cucurbituril derivatives have the formula (1) where X is O, S or NH; R1 and R2 are independently selected from the group consisting of hyd... | 01/09/2007 |
| 7151096 | Cyclic compounds and compositions as protein kinase inhibitors The invention provides a novel class of cyclic compounds, pharmaceutical compositions comprising such cyclic compounds and methods of using such compounds to treat or prevent diseases and disorders associated with cyclin-dependent kinases (CDKs) activity, particular... | 12/19/2006 |
| 7148347 | Process for preparing macrocyclic compounds Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R | 12/12/2006 |
| 7081452 | Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid compounds with a pendant donor amino group, metal complexes thereof, compositions thereof, and methods of use in diagnostic imaging and treatment of a cellular disorder. ... | 07/25/2006 |
| 7064119 | Fused bicyclic pyrimidine derivatives A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following general formula (1): ... | 06/20/2006 |
