Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8093379 | Macrocyclic serine protease inhibitors Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula I, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection i... | 01/10/2012 |
| 7429565 | Antiviral phosphonate analogs The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing su... | 09/30/2008 |
| 7381743 | Macrocycles for the treatment of cancer The present invention relates to new macrocycles of the general formula (I) as well as their use for the treatment of cancer diseases ... | 06/03/2008 |
| 7323455 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/29/2008 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7176001 | Manufacture and purification of cyclosporin A The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation of Fusarium solani in a bioreactor under optimal fermentation parameters. The product is extracted and f... | 02/13/2007 |
| 7176208 | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors The present invention relates to compounds of Formula I or II, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C v... | 02/13/2007 |
| 7122662 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 10/17/2006 |
| 7074961 | Antidepressants and their analogues as long-acting local anesthetics and analgesics Methods and compositions of antidepressants and analogs thereof for inducing local long-lasting anesthesia and analgesia are provided. The methods and compositions are useful for alleviating acute and chronic pain, particularly useful for treating a localized pain. | 07/11/2006 |
| 7030107 | Fused bicyclic pyridine derivatives as tachykinin receptor antagonists A novel fused bicyclic pyridine derivative or a salt thereof that acts as a tachykinin receptor antagonist, in particular as an NK1 receptor antagonist, is represented by the following general formula (1): ... | 04/18/2006 |
| 7012140 | Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents The present invention is directed, in general, to a contrast agent comprising a tetraazacyclododecane ligand and comprising a macrocyclic ring and a paramagnetic metal ion coordinated to the tetraazacyclododecane ligand. Pendent arms R, R′, R″ and R′″ attach... | 03/14/2006 |
| 7012166 | Catalyst composition and method for chlorinating aromatic compounds Aromatic compounds such as toluene and o-xylene are chlorinated in the presence of a catalyst combination prepared by combining (A) at least one salt comprising a metal selected from the group consisting of a Group 4–12 metal, a lanthanide and an actinide; and a c... | 03/14/2006 |
| 6995153 | Fused bicyclic pyrimidine derivatives A novel fused bicyclic pyrimidine derivative or a salt thereof that acts as a tachykinin receptor antagonist and, in particular, as an NK1 receptor antagonist is represented by the following general formula (1): wherein... | 02/07/2006 |
| 6984734 | Cyclo[n]pyrroles and methods thereto The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers,... | 01/10/2006 |
| 6984635 | Dimerizing agents, their production and use Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells. ... | 01/10/2006 |
| 6962992 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reacti... | 11/08/2005 |
| 6924277 | Cyclized benzamide neurokinin antagonists for use in therapy Compounds having the general formula wherein R1a, R1b, R1c, X1, X2, R2, R3, R4, R5, R6, n, Y and Z are as de... | 08/02/2005 |
| 6911428 | Diaryl peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention is directed to certain diaryl amide compounds as NS3-Serine protease inhibitors of hepatitis C virus. A particularly preferred compound is of the formula: ... | 06/28/2005 |
| 6903129 | D-proline prodrugs The invention relates to compounds of formulas wherein R1 and R2 are independently from each other lower alkoxy, lower alkenyloxy, benzyloxy, hydroxy, —OCH(CH3)OC(O)-lowe... | 06/07/2005 |
| 6846814 | Neurokinin antagonists for use as medicaments Compounds having the general formula wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X | 01/25/2005 |
| 6841530 | Semi-synthetic studies toward didemnin analogues Disclosed are semi-synthetic methods for the preparation of Didemnin Analogs. The compounds of this type are illustrated in Formula (I). ... | 01/11/2005 |
| 6821963 | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical,... | 11/23/2004 |
| 6680311 | Cryptophycin compounds The present invention provides cryptophycin compounds of Formula I ##STR1## that are useful in the treatment of neoplasms.... | 01/20/2004 |
| 6656930 | Aralkyl diazabicycloalkane derivatives for CNS disorders Certain aralkyl diazabicycloalkyl compounds are disclosed for treatment of CNS disorders, such as cerebral ischemia, psychosis, and convulsions. For example, compounds of interest are of the formula: ##STR1##... | 12/02/2003 |
| 6632929 | Avidin derivatives and uses thereof A covalent conjugate of a 4'-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: ##STR1## wherein A is (CH2)n or --CH.dbd.CH--, wherein n is an integer from 0-10; B is (CH2) | 10/14/2003 |
| 6608027 | Macrocyclic peptides active against the hepatitis C virus The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. ##STR1## wherein W, R21, R22, R3, R4, D and A are as defi... | 08/19/2003 |
| 6593360 | 8a- and 9a-15-membered lactams The invention relates to novel 15-membered 8a- and 9a-lactams from the class of 6-O-methyl-erythromycin A of general formula (I) ##STR1## their pharmaceutically acceptable addition salts with inorganic or organic acids and their hydrates, to intermediates... | 07/15/2003 |
| 6545038 | Heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of... | 04/08/2003 |
| 6489314 | Epothilone derivatives and methods for making and using the same The present invention relates to 16-membered macrocyclic compounds. In one aspect of the present invention, compounds of the formula ##STR1## are provided wherein: R1, R2, R3, and R5 are each independently hydrogen, ... | 12/03/2002 |
| 6468996 | Substituted hetero-polycyclic compounds as PPAR and PPARγ activators The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 10/22/2002 |
| 6384014 | Purified form of streptogramines, preparation of same and pharmaceutical compositions containing them Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general... | 05/07/2002 |
| 6358985 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 03/19/2002 |
| 6288073 | Acronycine derivatives, preparation method and pharmaceutical compositions A compound selected from those of formula (I): ##STR1## in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents h... | 09/11/2001 |
| 6277839 | Biphenylene lactams as prostaglandin receptor ligands The present invention relates to biphenylene lactams of Formula II which are ligands at the prostaglandin receptors, as well as a method for treating prostaglandin mediated diseases comprising administration to a patient in need of such a treatment of a n... | 08/21/2001 |
| 6180619 | Prenyl transferase inhibitors A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by the four following formulas ##STR1## Each of the R groups is defined in the disclosure.... | 01/30/2001 |
| 6177551 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent oth... | 01/23/2001 |
| 6147071 | Cyclic compounds, their production and use Novel compounds of the following general formula or salts thereof. ##STR1## wherein Ring M is a heterocyclic ring having --N.dbd.CC | 11/14/2000 |
| 6124453 | Macrolides A novel class of macrolides in which i) positions 2 to 6 inclusive of the macrocyclic ring are provided by a piperidazinyl carboxylic acid residue; and/or ii) positions 7 to 9 inclusive of the macrocyclic ring are provided by an aromatic -amino acid res... | 09/26/2000 |
| 6107482 | Nitrogenous macrocyclic compounds Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconn... | 08/22/2000 |
| 6069114 | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators Compounds of the formula (I) and their salts ##STR1## in which R1 to R6, Y1, to Y2, Y3, m and n are as defined in claim 1 are suitable as herbicides and plant growth regulators. They can be prepa... | 05/30/2000 |
