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| Number | Title | Issue Date |
| 7314705 | Compositions, systems, and methods for imaging A composition, method, and system for recording an image. The system includes an imaging material in which radiation energy is absorbed by an antenna material. The antenna material may be chosen from the group consisting of phthalocyanines and naphthalocyanines.... | 01/01/2008 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7220855 | Process for producing methylcobalamin The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cyanocobalamin or hydroxocobala... | 05/22/2007 |
| 7087384 | Rare earth metal cryptates which are not very sensitive to the fluorescence quenching The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates which are not very sensitive to this fluorescence quenching, said rare ea... | 08/08/2006 |
| 7083984 | Hybrid phthalocyanine derivatives and their uses Water soluble hybrid phthalocyanine derivatives useful in competitive and noncompetitive assays immunoassays, nucleic acid and assays are disclosed and claimed having (1) at least one donor subunit with a desired excitation peak; and (2) at least one acceptor subuni... | 08/01/2006 |
| 7083904 | Compositions, systems, and methods for imaging A composition, method, and system for recording an image. The system includes an imaging material in which radiation energy is absorbed by an antenna material. The antenna material may be chosen from the group consisting of phthalocyanines and naphthalocyanines.... | 08/01/2006 |
| 7033541 | Bicarbonate receptor compounds The present invention relates to compounds and more particularly to compounds which are useful for the determination of bicarbonate and the delivery of bicarbonate to a non-aqueous solution. The invention further relates to an optical sensor for the determination of... | 04/25/2006 |
| 6962992 | Crown ether derivatives The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reacti... | 11/08/2005 |
| 6936700 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hyd... | 08/30/2005 |
| 6657057 | Process for production of methylcobalamin The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which comprises the step of methylating cyanocobalamin or hydroxocob... | 12/02/2003 |
| 6605599 | Epothilone derivatives The present invention relates to epothilone derivatives, having the following formula ##STR1## in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1 -R7 are as defined herein, method... | 08/12/2003 |
| 6534649 | Silica gel incorporating polyazacycloalkane units comprising more than six nitrogen atoms, preparation process and use Compound of formula (I): ##STR1## in which W1, W2 and W3, which are identical or different, each represent, independently of one another, a divalent radical chosen from those represented by the general formula (A): --[(CT | 03/18/2003 |
| 6441020 | Protein kinase C modulators. W. Compositions of matter having protein kinase C-modulatory, anti-inflammatory and other biological activities are disclosed. The compositions are derived from indolactams which have a substituent, containing at least one carbon, at the N1 positi... | 08/27/2002 |
| 6180113 | Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.... | 01/30/2001 |
| 6127536 | Synthesis of a tetraamido macrocycle ligand An improved synthesis for preparing a tetraamido-macrocyclic ligand, such as 5,6-Benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10 -tetraazacyclotridecane, H4, in greatly improved yield and in a commercially viable manner, comp... | 10/03/2000 |
| 6100394 | Long-lived homogenous oxidation catalysts A robust chelate complex is provided having the formula: ##STR1## wherein: M is a metal, preferably a transition metal; Z is an anionic donor atom, three of which are nitrogen, and the other is oxygen; L1 is a labile ligand; Ch1... | 08/08/2000 |
| 5981783 | Chiral ligand system for main group and transition metal catalysts A chiral ligand system for transition or main group metal catalysts is disclosed. These ligands can be readily synthesized using inexpensive amino acids and diamines as starting materials. Several different transition or main group metals have been insert... | 11/09/1999 |
| 5962498 | Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity Compounds having anti-inflammatory, anti-viral, protein kinase C-modulatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class, each bearing an addi... | 10/05/1999 |
| 5912238 | Heteroatoms-containing tricyclic compounds The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances. They are prepared by several processes including epimerizing replacement, treatment with cyanogen bromide or thiophosgene, treatment with ... | 06/15/1999 |
| 5891870 | Protein kinase C modulators Q Compositions with anti-inflammatory and other activitites are disclosed. The compositions are derived from phorboids of the diterpene- and benzolactam-classes.... | 04/06/1999 |
| 5756688 | MR imaging compositions and methods This invention provides compositions useful in MR imaging comprising a polymer comprising units comprising the residue of a chelating agent linked to a poly(alkylene oxide) moiety, the polymer having a paramagetic metal ion associated therewith.... | 05/26/1998 |
| 5728710 | Rapamycin derivatives Rapamycin derivatives; pharmaceutical compositions comprising such rapamycin derivatives and pharmaceutically acceptable carriers or diluents; and methods of using such derivatives to inhibit pathogenic fungi growth inhibition, inhibit immunosuppression o... | 03/17/1998 |
| 5721361 | Process for preparing substituted polyazamacrocycles A process for preparing a substituted polyazamacrocycle is provided which comprises contacting a diamine or triamine and a dicarboxylic acid or ester or anhydride thereof in the presence of a suitable base and a suitable solvent to produce the substituted... | 02/24/1998 |
| 5690909 | Fluorine-containing macrocyclic metal complexes The invention relates to new fluorine-containing macrocyclic metal complexes that consist of a complexing agent of formula I and at least one metal ion of an element of atomic numbers 21-29, 42, 44 or 57-83 ##STR1## in which n, R1, R2... | 11/25/1997 |
| 5672605 | Macrolide immunomodulators Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical c... | 09/30/1997 |
| 5622821 | Luminescent lanthanide chelates and methods of use The invention provides lanthanide chelates capable of intense luminescence. The celates comprise a lanthanide chelator covalently joined to a coumarin-like or quinolone-like sensitizer. Exemplary sensitzers include 2- or 4-quinolones, 2- or 4-coumarins, o... | 04/22/1997 |
| 5614649 | Multicatalytic protease inhibitors Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed ... | 03/25/1997 |
| 5589473 | Mono- and bicyclic DNA gyrase inhibitors The present invention relates to a compound of the formula ##STR1## wherein X1, R1, R2, OP, R3, R4, R5, R6, and R0 are as described herein, and their pharmaceutically ... | 12/31/1996 |
| 5583219 | Macrocyclic chelating agent A novel bifunctional macrocyclic chelating agent useful for attaching metal ions to proteins, polypeptides and other polymers. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per prote... | 12/10/1996 |
| 5583139 | Marcolide immunomodulators Novel macrolide compounds of the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical c... | 12/10/1996 |
| 5565561 | Natural substance cyclamenol and chemical derivatives The invention relates to the natural substance cyclamenol of the formula ##STR1## a process for its preparation from microorganisms of the order of the Actinomycetales, in particular from the Streptomyces strain MHW 846, chemical derivatives thereof,... | 10/15/1996 |
| 5563127 | Boronic acid and ester inhibitors of thrombin Novel boronic acid and ester and carboxyl-modified amino acid compounds of the Formula I, which are inhibitors of trypsin-like enzymes, are disclosed : R1 --Z--CHR2 --A, where R1, Z, R2 and A are defined within.... | 10/08/1996 |
| 5561140 | Substituted alicyclic amine-containing macrocyclic immunomodulators Compounds having the formula ##STR1## and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R104 and R105 is hydrogen, and the other of R104 and R105 is a group having t... | 10/01/1996 |
| 5561139 | Substituted alicyclic-aliphatic amine-containing macrocyclic immunomodulators Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R104 and R105 is hydrogen, and the other of R104 and R105 is a radical ha... | 10/01/1996 |
| 5554749 | Functionalized macrocyclic ligands for imaging applications The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein U is --(CH2)n X or --(CH2)n NR1 (CH2)X; R1 | 09/10/1996 |
| 5532248 | O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppre... | 07/02/1996 |
| 5530120 | Substituted alicyclic aliphatic-amine containing macrocyclic immunomodulators Compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R104 and R105 is hydrogen, and the other of R104 and R105 is a radical ha... | 06/25/1996 |
| 5508397 | Activated macrolactams Activated macrolactam compounds having the formula ##STR1## wherein n is zero or one, R101 is selected from the group consisting of methyl, ethyl, allyl, propyl and cyclopropylmethyl; R102 is hydrogen, and R103 is selected... | 04/16/1996 |
| 5493019 | Tetrahydropyran derivatives The invention concerns the compounds of formula I ##STR1## wherein the substituents have various significances, in free form and, where such forms exist, in salt form. They can be prepared by various processes, e.g. by irradiation; oxidation; elimina... | 02/20/1996 |
| 5484685 | Naphthalocyanine derivatives, production thereof, optical recording medium using the same, and production thereof A naphthalocyanine derivative of the formula: ##STR1## wherein M, Y, R1, k, l, m, n are as defined in the specification, is an effective substance for forming a recording layer on a substrate of an optical recording medium having high sens... | 01/16/1996 |
