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| Number | Title | Issue Date |
| 7468434 | Diazene-bridge crown ether lithium compounds and methods for their use This invention provides a method for treating an eye disease in a patient comprising: providing a photosensitive prodrug that releases upon exposure to light an active ingredient to treat the eye disease; administering the prodrug in a pharmaceutically accepted vehi... | 12/23/2008 |
| 7452992 | Heterocyclic compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an... | 11/18/2008 |
| 7407645 | Bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands The present invention is directed to bioconjugates of complexes represented by the formula: wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, ... | 08/05/2008 |
| 7402670 | Synthesis by chiral diamine-mediated asymmetric alkylation Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid. ... | 07/22/2008 |
| 7385054 | Trimeric, macrocyclically substituted halo-benzene derivatives The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media. ... | 06/10/2008 |
| 7368443 | 2,6-disubstituted piperidines and piperazine compounds The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal there... | 05/06/2008 |
| 7335672 | Vanilloid receptor ligands and their use in treatments Substituted pyridines and pyrimidines and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inf... | 02/26/2008 |
| 7332511 | Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an... | 02/19/2008 |
| 7323563 | Hydroxamic acid derivatives as antibacterials A method for the treatment of bacterial infections in humans and non-human mammals, which comprises inhibiting bacterial growth by administering to a subject an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily accepta... | 01/29/2008 |
| 7319123 | Use of sulfur containing initiators for anionic polymerization of monomers An initiator is presented for anionically polymerizing monomers, to provide a functional head group on the polymer. A polymer having a functional head group derived from a sulfur containing anionic initiator, and optionally as additional functional group resulting f... | 01/15/2008 |
| 7311970 | Medical device having surface modification with superoxide dismutase mimic A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the porti... | 12/25/2007 |
| 7271154 | Antibiotic conjugates This invention features a compound of the following formula: wherein T is a transportophore, L is a bond or linker, and C is an antibiotic therapeutic agent, the transportophore is covalently bonded to the antibi... | 09/18/2007 |
| 7196084 | Cdc25 phosphatase inhibitors The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected amon... | 03/27/2007 |
| 7186400 | Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy Compounds of general formula (I): in which: R1 is hydrogen, C1–C20 alkyl, C3–C10 cycloalkyl, C4–C20 cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyc... | 03/06/2007 |
| 7161000 | Method for producing phenol condensate Provided is a method for producing a phenol condensate by oxidative condensation of a phenol compound not having a substituted group on at least one ortho-position, in the presence of a specific complex (II) and oxygen, wherein a condensate coupled at para-position ... | 01/09/2007 |
| 7153919 | Use of sulfur containing initiators for anionic polymerization of monomers An initiator is presented for anionically polymerizing monomers, to provide a functional head group on the polymer. A polymer having a functional head group derived from a sulfur containing anionic initiator, and optionally as additional functional group resulting f... | 12/26/2006 |
| 7141560 | Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of th... | 11/28/2006 |
| 7137423 | Tire with component comprised of amine functionalized styrene/diene copolymer elastomer, silanol functionalized carbon black and coupling agent The invention relates to a tire having at least one component (e.g. tread) of a rubber composition comprised of an amine functionalized styrene/conjugated diene copolymer elastomer (e.g. styrene/butadiene and/or styrene/isoprene/butadiene copolymer elastomer) which ... | 11/21/2006 |
| 7125442 | Lightfast additive having UV-absorbing moiety and ink composition including the same A lightfast additive and an ink composition including the same include a benzophenone moiety for lightfastness and a moiety for wettability and the ability to stabilize a colorant, wherein the two moieties are covalently bonded. The lightfast additive may exhibit ef... | 10/24/2006 |
| 7125535 | Method of preparing anhydrous manganese chloride An efficient process for forming anhydrous metal halides includes the reaction of a metal powder with a hydrogen halide under anhydrous conditions. In one example, manganese powder is reacted with hydrogen chloride under anhydrous reaction conditions. ... | 10/24/2006 |
| 7122335 | Compounds and methods to enhance rAAV transduction Agents and methods to alter rAAV transduction, including agents and methods to enhance rAAV transduction, are provided. For instance, the invention provides methods to identify agents that enhance AAV transduction after viral binding to the cell membrane and before ... | 10/17/2006 |
| 7122677 | NK1 antagonists A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5... | 10/17/2006 |
| 7060818 | Synthesis of macrocyclic tetraamido compounds and new metal insertion process An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbo... | 06/13/2006 |
| 7056910 | 1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof. ... | 06/06/2006 |
| 6962690 | Tissue specific fluorescent chelates possessing long wavelength UV excitation Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents for soft tissue cancers. | 11/08/2005 |
| 6949537 | PI-3 kinase inhibitor prodrugs The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 09/27/2005 |
| 6943177 | Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well as to treating eating diso... | 09/13/2005 |
| 6943250 | Protected aminofunctionalized polymerization initiators and methods of making and using same Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality is part of a heterocyclic radical and includes a protecting group. ... | 09/13/2005 |
| 6936700 | Bridged aromatic substituted amine ligands with donor atoms The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hyd... | 08/30/2005 |
| 6936189 | Cyclic tertiary amine compound and organic electroluminescent device containing the compound A cyclic tertiary amine compound represented by a formula (1) and an organic luminescent device are disclosed. Use of the cyclic tertiary amine compound as a hole transport material, a hole injection material or an organic electroluminescent material can provide org... | 08/30/2005 |
| 6921822 | Process for stereoselectively reducing 4-aryl-4-oxobutanoic acid derivatives The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts. ... | 07/26/2005 |
| 6881230 | Dyeing composition for dyeing keratinous fibers comprising a cationic azo-dye The invention concerns a novel dyeing composition for dyeing keratinous fibers, in particular human hair, comprising a cationic azo-dye of formula (I): W1-N═N-W2-W3, as well as the dyeing method using said composition and the novel compounds of formula (I). ... | 04/19/2005 |
| 6818149 | Ligand and complex for catalytically bleaching a substrate The present invention provides a bleaching composition comprising a [3.3.1] bicyclo compound carrying at least one tertiary amine group the bleaching composition substantially devoid of a peroxygen source. ... | 11/16/2004 |
| 6806378 | Process for preparing nonracemic chiral alcohols The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic chiral diphosphine ligand, an amin... | 10/19/2004 |
| 6803462 | Process for synthesizing functionalized styrene monomer This invention discloses a rubbery polymer which is comprised of repeat units that are derived from (1) at least one conjugated diolefin monomer, and (2) at least one functionalized monomer having of the structural formula: ... | 10/12/2004 |
| 6794506 | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, a... | 09/21/2004 |
| 6762304 | Metal catalysts and methods for making and using same Compounds having the formula: are disclosed. M1 and M2 are the same or different and are transition metal atoms or ions; Z2 and Z3, independently, are the atoms necessary to co... | 07/13/2004 |
| 6753447 | Functionalized monomers for synthesis of rubbery polymers This invention discloses a process for synthesizing an amine functionalized monomer that comprises (1) reacting a secondary amine with a 2,3-dihalopropene to produce a vinyl halide containing secondary amine having a structural formula selected from the group consis... | 06/22/2004 |
| 6746595 | Ammonium ionophore, an ammonium ion selective matrix, an ammonium ion-selective sensor, and a method for detecting ammonium ions in a fluid sample An ammonium selective ionophore for use in ion selective electrodes. ... | 06/08/2004 |
| 6734177 | Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said salts. ... | 05/11/2004 |
