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| Number | Title | Issue Date |
| 7268125 | β-lactamyl vasopressin V antagonists Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor | 09/11/2007 |
| 7179907 | Antibiotic compounds The present invention provides methods for identifying (3-amino-2-oxo-azetidin-1-yl) acetic acid derivatives with anti-PBP2a activity. The method involves the selection of RNA biocatalysts that promote the formation of (3-amino-2-oxo-azetidin-1-yl) acetic acid deriv... | 02/20/2007 |
| 7144696 | Use of azetidinone compounds The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can... | 12/05/2006 |
| 7119083 | β-Lactamyl vasopressin VAntagonists Novel 2-(azetidin-2-on-1-yl)alkanedioic acid derivatives and 2-(azetidin-2-on-1-yl)alkoxyalkanoic acid derivatives are described for use in the treatment of disease states responsive to antagonism of the vasopressin V1a receptor. ... | 10/10/2006 |
| 7067509 | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto Melanin-concentrating hormone (MCH) receptor antagonists are disclosed having utility for the treatment of MCH receptor-based disorders such as obesity. The compounds of this invention have the following structure: | 06/27/2006 |
| 7067532 | Substituted quinolines as antitumor agents The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt pro-drug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) a... | 06/27/2006 |
| 6900312 | Thiazole-substituted β-lactams The present discovery consists in new thiazole-substituted β-lactams of general formula (I), as well as the method for their preparation. R1, R2, R3, R4, R5, R6, R7, and R8 are, independently from each other, a hydrogen... | 05/31/2005 |
| 6602864 | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit... | 08/05/2003 |
| 6579989 | Sulphostin analogue and process for producing sulphostin and its analogue A sulphostin analogue represented by the general formula, ##STR1## wherein n is an integer of from 0 to 3, provided that a case where n is 2 and steric configurations of C* and P* are S and R, respectively, is excluded, or a pharmaceutically acceptable sa... | 06/17/2003 |
| 6562962 | Preparation of substituted isoserine esters using metal alkoxides and ଲ-lactams A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a ଲ-lactam.... | 05/13/2003 |
| 6509463 | Isocyanoalkylcarbonic acid derivatives, the reaction thereof in isocyanide multicomponent reactions to form sec-amido-alkylcarbonic acid derivatives, and those sec-amidoalkyl-carbonic acid derivatives The present invention relates to compounds of the general formula I ##STR1## wherein A is a group of the formula ##STR2## and Z is an O or S atom, to the further processing thereof to form novel sec-amidoalkylcarbonic acid derivatives and to those se... | 01/21/2003 |
| 6281227 | Sulfonic acid sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit... | 08/28/2001 |
| 6127543 | Antimalarial organometallic iron complexes Organometallic iron complexes containing one or more basic structural components characterizing a molecule with antimalarial properties such as quinine, chloroquinine or mepacrine, as well as one or more iron atoms are described. The complexes of the inve... | 10/03/2000 |
| 6031094 | Beta-lactam substrates and uses thereof | 02/29/2000 |
| 6011151 | Process for preparing ଲ-lactam halide compound A process for preparing a ଲ-lactam halide compound represented by the formula (2) characterized by halogenating the allenyl group of an allenyl ଲ-lactam compound represented by the formula (1) with a cupric halide and a metal halide to obtain ... | 01/04/2000 |
| 5728827 | Process for the synthesis of azetidinones This invention provides a process for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, particularly for azetidinones substituted in the C-3 and C-4 positions and optionally substituted at the rin... | 03/17/1998 |
| 5708169 | 5-amidomethyl ,ଲ-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents The present invention provides for new 5-amidomethyl, ,ଲ-saturated and--unsaturated butyrolactone antibacterial agents of formula I ##STR1## characterized by 3-aryl substituents that include, for example, indolinyl and phenyl substi... | 01/13/1998 |
| 5561227 | Process for the stereospecific synthesis of azetidinones This invention provides an improved process for producing azetidinones. More particularly, this invention provides the steps of producing an azetidinone represented by the formula I ##STR1## from a carboxylic acid R2 --D--CH2 CO... | 10/01/1996 |
| 5539103 | ଲ-lactams as taxol intermediates N-acylated ଲ-lactam compounds which are reacted with a metal alkoxide for preparing N-acyl, N-sulfonyl and phosphoryl substituted isoserine esters.... | 07/23/1996 |
| 5482920 | Triazinyl compounds with herbicidal activity Pyrimidinyloxy- and triazinyloxy- and pyrimidinylthio- and triazinylthio-butyric acid derivatives of formula I ##STR1## wherein Q is ##STR2## A is hydroxy or a group ##STR3## and the other substituents are as described in patent claim ... | 01/09/1996 |
| 5334328 | Chiral azetidinone derivatives, and their use as dopes in liquid-crystal mixtures Azetidinones of the formula I ##STR1## in which, for example, R1 is an alkyl or alkenyl radical, R2 and R3 are hydrogen or an alkyl or alkenyl radical, Z is hydrogen or (pseudo)halogen, A1, A2 an... | 08/02/1994 |
| 5250676 | Process for the preparation of 3-substituted-2-azetidinones Provided is a process for diastereoselectively preparing compounds of the formula ##STR1## which includes the step of subjecting a compound of the formula ##STR2## to a salt whose anion is a nucleophilic base whose conjugate acid has a pKa ... | 10/05/1993 |
| 5239069 | Amino protecting group The invention provides compounds of the formula ##STR1## wherein R* is a group of the formula ##STR2## wherein R and R0 are individually C1 -C6 alkyl groups or together form a ring consisting of the nitrogen atom... | 08/24/1993 |
| 5229381 | Substituted azetidinones as anti-inflammatory and antidegenerative agents New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1##... | 07/20/1993 |
| 5194604 | Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains Disclosed herein are processes for preparing a compound of the formula ##STR1## in which a novel compound of the formula ##STR2## is reacted with a beta lactam of the formula ##STR3## by treatment with a base, wherein the symbols are as def... | 03/16/1993 |
| 5169945 | Amino protecting group The present invention provides a process for protecting an amino group in a compound exposed to nucleophilic reaction conditions in which the imido group used for protection is reacted with a secondary amine to form an acyl group which protects the amino ... | 12/08/1992 |
| 5137884 | N-tetrazolyl beta-lactams N-tetrazolyl beta-lactams of the Formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R2 is hydrogen, alkyl having 1 to 6 carbon atoms or carboalkoxy having 2 to 7 carbon atoms; and Z is ##STR2## and W is ... | 08/11/1992 |
| 5106475 | Process for preparing 4-substituted azetidinones A process for preparing 3-4-cis-ଲ,ଲ-(4)-substituted and 3-4-trans,ଲ,-(4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.... | 04/21/1992 |
| 5106977 | Intermediates for a process for making 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines Novel intermediates for preparing 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl]azetidines are disclosed. These intermediates have the formula ##STR1## wherein Prot is as defined herein.... | 04/21/1992 |
| 5037983 | 6,7-dihydroxyquinoxalines as intermediates to beta-lactam antibiotics Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activiy, and intermediates to compounds of formula I having the formula ##STR2##... | 08/06/1991 |
| 5028711 | Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds Benzopyran derivatives of the general formula I ##STR1## are disclosed. The compounds are therapeutic active compounds.... | 07/02/1991 |
| 5015737 | Therapeutically useful beta-lactams This invention presents novel 2-azetidinone compounds of the formula ##STR1## wherein R1 and R2 are the same or different and are hydrogen (C1 -C12) alkyl, (C2 -C8) alkenyl, (C2 ... | 05/14/1991 |
| 5006650 | Novel N-1 substituted beta-lactams as antibiotics This invention presents novel 2-azetidinone compounds of the formula ##STR1## wherein R10 and R15 are the same or different and are (a) hydrogen, (b) (C1 -C12) alkyl, (c) (C2 -C8) alkenyl, ... | 04/09/1991 |
| 5001235 | Antibiotic beta-lactams containing a pyridone carboxylic acid or acid derivative This invention presents novel 2-azetidinone compounds of the formula ##STR1## wherein R80 is --CO2 R5 or --CONR6 R7 ; wherein R5 is hydrogen or (C1 -C4) alkyl; and whe... | 03/19/1991 |
| 4992545 | Process for preparing 4-substituted azetidinones A process for preparing 3-4-cis-ଲ,ଲ-(4)-substituted and 3-4-trans,ଲ,- (4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.... | 02/12/1991 |
| 4983732 | Method of deprotection of 3-amino azetidinones A method for preparing 2-amino-ଲ-lactams which are substituted by readily-removed protecting groups is provided. According to this invention, an acyl-2-amino-ଲ-lactam is further acylated with a different acyl group and is subsequently treated ... | 01/08/1991 |
| 4980465 | Process for making 2-oxo-1-[[(substituted sulfonyl)-amino]carbonyl)] azetidines and intermediates used therein An improved process for making compounds having the formula ##STR1## includes subjecting an intermediate of the formula ##STR2## to hydrogenolysis in the presence of a ketonic solvent so as to simultaneously remove both Z-protecting groups from ... | 12/25/1990 |
| 4975538 | Antibiotic sulfonylaminocarbonyl activated beta-lactams This invention presents novel 2-azetidinone compounds which are useful as antibacterial agents to eradicate or control susceptible microbes of the formula ##STR1## wherein R401 and R402 are the same or different and are (a) ... | 12/04/1990 |
| 4959470 | 2-oxo-[[(substituted sulfonyl)-amino]carbonyl]-azetidines Componds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##... | 09/25/1990 |
| 4923983 | Method of resolving cis 3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2-one Cis /ଲଲ-3-amino-[2-(2-furyl)eth-1-yl]-1-methoxycarbony lmethyl-azetidin-2-one is resolved via optically active tartaric acid.... | 05/08/1990 |
