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| Number | Title | Issue Date |
| 7109003 | Methods for expressing and recovering human monoclonal antibodies to CTLA-4 In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, ... | 09/19/2006 |
| 6908996 | Compounds and method for preparing 3-methylcephams The present invention relates to novel intermediates for the preparation of 3-methylenecephams of the formula IIA. wherein: R is a carboxylic acid protecting group; R... | 06/21/2005 |
| 6221860 | Beta-lactam inhibitors of CoA-IT This invention relates to methods for treating diseases or disorders mediated by lipid inflammatory mediators, arachidonic acid, its metabolites and/or platelet activating factor (PAF), which method comprises administration to a mammal in need thereof of ... | 04/24/2001 |
| 6150519 | Process for preparing ଲ-lactam derivatives A process for preparing an allenyl ଲ-lactam compound represented by the formula (4), characterized by reacting the hydroxyl group of a ଲ-lactam compound represented by the formula (1) with a reactive functional group derivative of sulfonic aci... | 11/21/2000 |
| 6051678 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 04/18/2000 |
| 6011151 | Process for preparing ଲ-lactam halide compound A process for preparing a ଲ-lactam halide compound represented by the formula (2) characterized by halogenating the allenyl group of an allenyl ଲ-lactam compound represented by the formula (1) with a cupric halide and a metal halide to obtain ... | 01/04/2000 |
| 5986091 | Process for preparation of ଲ-lactam compounds The present invention provides a process for preparing an allenyl ଲ-lactam compound represented by the formula (II) or a process for preparing a 3-halocephem compound of the formula (III) by altering the reaction conditions with use of a ଲ-lac... | 11/16/1999 |
| 5977352 | Process for preparing 3-norcephem compounds The present invention provides a process for preparing 3-norcephem compound represented by the formula (2), characterized in that a hydride reagent is acted on a halogenated ଲ-lactam compound represented by the formula (1) in the presence of a cupro... | 11/02/1999 |
| 5929233 | Cyclization for preparing halo-cephems The invention provides a process for preparing an allenyl ଲ-lactam of formula (4), by reacting the hydroxyl group of a ଲ-lactam of formula (1) with a reactive derivative of sulfonic acid of formula (2) to convert the compound of formula (1) to... | 07/27/1999 |
| 5905147 | Process for preparing ଲ-lactam compound The present invention provides a process for producing a ଲ-lactam halide compound represented by the general formula (2) which process is characterized in that the hydroxyl group of a ଲ-lactam halide compound represented by the general formula... | 05/18/1999 |
| 5750680 | N-vinyllactam derivatives and polymer thereof N-vinyllactam derivatives protected at the 3-position are provided and represented by the following formula (I). These are polymerized into homo- and copolymers for use in microlithography of semiconductor manufacture. The polymers are used as a photoresi... | 05/12/1998 |
| 5728827 | Process for the synthesis of azetidinones This invention provides a process for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, particularly for azetidinones substituted in the C-3 and C-4 positions and optionally substituted at the rin... | 03/17/1998 |
| 5693792 | ଲ-lactam and cephem compounds and processes for their production The object of the invention is to provide a ଲ-lactam compound and a 2-substituted methyl-3-cephem compound, both of which are of value as intermediates for the synthesis of cephem antibiotics. The ଲ-lactam compound of the invention may be represent... | 12/02/1997 |
| 5604222 | Method for the preparation of 2-chloro sulfinyl azetidinones An improved method for the preparation of 2-chloro sulfinyl azetidin-4-one of the formula: ##STR1## wherein R is: hydrogen; C1 -C3 alkyl; halomethyl; cyanomethyl; phenyl; substituted phenyl; phenoxy, benzyloxy- or substituted be... | 02/18/1997 |
| 5453502 | 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof The invention provides 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes therefor. These compounds are valuable intermediates useful in the preparation of 1-carba(dethia)cephalosporin antibiotics.... | 09/26/1995 |
| 5405955 | Method for producing azetidinone and cephalosporin derivatives New compounds are disclosed having the general formulas (1) and (2): ##STR1## Also described is a process for preparing the compounds of formulas (1) and (2). Further described is a process for preparing a cephalosporin derivative having formula (5):... | 04/11/1995 |
| 5399679 | (1'R,3S,4R)4-acylthio azetidinones There is provided a process for preparing a compound of formula (I) ##STR1## wherein R is H or a hydroxy protecting group, R2 is an organic residue and R3 is H or a nitrogen protecting group, which process comprises reacting tog... | 03/21/1995 |
| 5162524 | Processes for making cephems from allenylazetidinone derivatives This invention relates to a novel process for making a cephem of formula II from a 2-(3-amino-2-oxo-azetidin-1-yl)-2,3-butadienoate intermediate of formula I using an organo-copper reagent. In another aspect, this invention is concerned with said intermed... | 11/10/1992 |
| 5126447 | Process for preparation of ଲ-lactam derivative from an alkenyl substituted ଲ-lactam derivative using a ruthenium or rhenium catalyst and a periodic acid A process for preparing a ଲ-lactam derivative of formula (2) and/or the corresponding enol tautomer, which includes oxidizing an alkenyl-substituted ଲ-lactam derivative of formula (1) in the presence of a ruthenium catalyst or a rhenium cataly... | 06/30/1992 |
| 4948885 | Synthesis of azetidinones There is disclosed a compound represented by the formula ##STR1## wherein each P is hydrogen or a hydroxy protecting group and R and R' are each the same and are hydrogen, ##STR2## wherein R" is lower alkyl and R'" is a carboxy protecting group.... | 08/14/1990 |
| 4810788 | Azetidinone disulfide derivatives and a process for preparing the same An azetidinone derivative represented by the formula (I) ##STR1## wherein R1 is substituted or unsubstituted phenyl or substituted or unsubstituted phenoxy, R2 is hydrogen, optionally substituted hydrocarbon residue or aminoprot... | 03/07/1989 |
| 4801720 | Azetidinone disulfides and a ring opening process for preparing the same An azetidinone derivative represented by the formula (I) ##STR1## wherein R1 is substituted or unsubstituted phenyl or substituted or unsubstituted phenoxy, R2 is hydrogen, optionally substituted hydrocarbon residue or amino-pro... | 01/31/1989 |
| 4798828 | Heterocyclic-methylene-penems Compounds of the general formula I: ##STR1## and their pharmaceutically acceptable salts and in vivo hydrolyzable esters, in which one of R1 and R2 denotes hydrogen, the other of R1 and R2 denotes an unsubstitut... | 01/17/1989 |
| 4798890 | Process for preparation of azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R1 is hydrogen, halogen or lower alkoxy, R2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R5 | 01/17/1989 |
| 4789740 | Halogenation process for preparing 2-(oxoazetidinyl)-3-chloromethyl-3-butenoate A process for preparing an azetidinone derivative represented by the formula (I) ##STR1## wherein R1 represents an aryl group, arylmethyl group or aryloxymethyl group, R2 represents hydrogen atom or a carboxyl-protecting gr... | 12/06/1988 |
| 4784734 | Azetidinone derivatives and process for the preparation of the same This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.... | 11/15/1988 |
| 4767853 | Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbony lthio-2-azetidinones and hydroxy protected analogs thereof A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy thiocarbonylthio-2-azetidinones, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinone... | 08/30/1988 |
| 4740596 | Process for preparation of 4-sulfonylthio azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R1 is hydrogen, halogen or lower alkoxy, R2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R5 | 04/26/1988 |
| 4713452 | Process for preparation of azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R1 is hydrogen, halogen or lower alkoxy, R2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R5 | 12/15/1987 |
| 4689411 | 4-thio azetidinone intermediates and process for the preparation of the same This invention provides azetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The azetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful as antibiotic agents.... | 08/25/1987 |
| 4622178 | Process for preparing azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R1 represents a straight-chain or branched-chain lower alkyl group, substituted or unsubstituted aryl group, substituted or unsubstituted ph... | 11/11/1986 |
| 4587048 | Process for the manufacture of 4-thioazetidinone compounds The present invention relates to a novel process for the manufacture of 4-thioazetidinone compounds of the formula ##STR1## in which R1a represents an amino-protecting group and R1b represents hydrogen or a... | 05/06/1986 |
| 4585874 | Process for preparing penem derivatives A new process is described for the preparation of (5R)-penem derivatives of the general formula I: ##STR1## wherein R1 represents a hydrogen atom or an organic group; R2 represents a hydrogen atom or a carboxy protecting group a... | 04/29/1986 |
| 4579684 | Process for the manufacture of enol derivatives The invention concerns a process for the manufacture of 7ଲ-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolysing t... | 04/01/1986 |
| 4576939 | Penem derivatives What are disclosed are penem compounds of the formula ##STR1## wherein R is hydrogen, a cation, or an esterifying group and R1 is alkyl or aryl, methods for making such compounds, methods for using the compounds as a ଲ-lactamase inhi... | 03/18/1986 |
| 4566996 | Process for preparing azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula (1) ##STR1## wherein R1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted phenylmethyl group or a substituted or unsubstit... | 01/28/1986 |
| 4566995 | Process for the preparation of benzothiazepine derivatives The present invention relates to a process for the preparation of benzothiazepine derivatives of general formula I ##STR1## wherein R stands for hydrogen and acetyl or of acid addition salts thereof in which a corresponding compound of general formul... | 01/28/1986 |
| 4524028 | Monocyclic intermediates for thia-aza compounds with a ଲ-lactam ring 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group and R2 represents hydroxy or a radical R | 06/18/1985 |
| 4518533 | Azetidinone-4-disulfides as intermediates for thia-aza compounds with a beta-lactam ring 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group and R2 represents hydroxy or a radical R | 05/21/1985 |
| 4515717 | Thia-aza compounds with a ଲ-lactam ring 2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group and R2 represents hydroxy or a radical R | 05/07/1985 |
