Class 540/355 - The additional chalcogen is bonded directly to the ring nitrogen

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the additional chalcogen is bonded directly
No. of patents: 114
Last issue date: 02/07/2012

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Number	Title	Issue Date
8110678	Antibiotic-bound poly(caprolactone) polymer This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic ...	02/07/2012
7601832	Process for making aztreonam A simplified process for the one-pot preparation of aztreonam, using azetidine and TAEM as starting materials, without the intermediary separation of t-butyl-aztreonam is provided. ...	10/13/2009
7452991	Aztreonam β polymorph with very low residual solvent content The invention relates to the β polymorph of Aztreonam, which contains less than 2.5% by weight residual solvent and to a process of making said polymorph. In the process of the invention, a polymorph of Aztreonam is dissolved in an absolute C1-6 alcohol ...	11/18/2008
7262293	Aztreonam L-lysine and methods for the preparation thereof The present invention relates to the L-lysine salt of aztreonam and methods for making the L-lysine salt of aztreonam. ...	08/28/2007
7214364	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, ...	05/08/2007
7208141	Inhalable aztreonam aerosol for treatment and prevention of pulmonary bacterial infections A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, ...	04/24/2007
7145017	Preparation of Aztreonam The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing [3S-[3α(Z),4β]]-3-[[(2-amino-4-thiazolyl)[(1-t-butoxycarbonyl-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidinesulfonic acid (t-Bu Aztreona...	12/05/2006
7138419	Process for manufacturing bulk solutions and a lyophilized pure α-aztreonam lysinate A process for manufacturing bulk solutions and lyophilized pure α-aztreonam lysinate for large scale production of an inhalable aztreonam is disclosed, as is a pure α-aztreonam lysinate for inhalation. A dry powder or lyophilized pure α-aztreonam lysinate composi...	11/21/2006
7026472	Methods for preventing and treating cancer using N-thiolated β-lactam compounds and analogs thereof The subject invention concerns N-thiolated β-lactam compounds of formula A, wherein R1 is a hydrocarbon group having 1–8 carbon atoms; R3 is an organothio group; and R4 is alkyl, alke...	04/11/2006
6946458	N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus The invention relates generally to novel N-thiolated β-lactams. More specially, the invention relates to the use of these novel antibacterial agents in the treatment or inhibition of methicillin-resistant Staphylococcus aureaus. ...	09/20/2005
6916803	3-(Heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents The present invention relates to novel Syn isomers of racemates and optical isomers of 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids of the following formula: and their use in treating infections caused by ...	07/12/2005
6617451	Enantioselective acylation of cis racemic azetidinones Cis-ଲ-lactam compounds having structure (II) are described herein which are prepared by enantioselective acylation of the free amine in the presence of Penicillin G Amidase. ##STR1##...	09/09/2003
6562962	Preparation of substituted isoserine esters using metal alkoxides and ଲ-lactams A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a ଲ-lactam....	05/13/2003
6495568	Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors Compounds of formula (I): ##STR1## or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents an optional bond; A is C or CH; B is CH...	12/17/2002
6476015	N-thiolated ଲ-lactam antibiotics Substituted monocyclic ଲ-lactam compounds that are N-1-thiolated monolactams, and which exhibit wide-ranging antibacterial activities, having a single 4-membered azetidinone ring in which: the N-1 nitrogen atom of the azetidinone ring is bonded to s...	11/05/2002
6437119	Compounds formed from two or three antibiotics and their processes of preparation Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, ଲ-lactams and vancomycin and the like as the starting materials and chloride linking agents; and the novel compounds prepared by these proc...	08/20/2002
6335324	Beta lactam compounds and their use as inhibitors of tryptase Compounds of the formulas: ##STR1## are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma....	01/01/2002
5994340	Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T...	11/30/1999
5986108	4-substitued-3-[1 or 2 amino acid residue]-azetidin-2-one derivatives useful as cysteine proteinase inhibitor Disclosed herein are azetidin-2-one compounds which exhibit excellent cysteine proteinase inhibitory activity. The compounds are 4-substituted-3-{1 or 2 amino acid residue}-azetidin-2-ones of forumula I ##STR1## wherein AAR is a 1 or 2 acid residue, ...	11/16/1999
5916887	4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators In accordance with the present invention, there are provided 4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives of the formula: ##STR1## wherein n is 1, 2 or 3; in which R1, R2 and R3 a...	06/29/1999
5888998	2-oxo-1-azetidine sulfonic acid derivatives as potent ଲ-lactamase inhibitors A compound of formula (I) ##STR1## wherein R1 is selected from the group consisting of 2-thienyl, 2-furyl, 2-pyrrolyl, 1-methyl-2-pyrrolyl, 2-amino-1-thiazolyl and 5-isothiazolyl; R2 is selected from the group consisting of: ...	03/30/1999
5760219	Pyridyl substituted B-lactam compounds Pyridyl substituted ଲ-lactam compounds used in preparing taxane derivatives having a 3' pyridyl substituted C13 side chain....	06/02/1998
5670638	2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, and preparation The azetidines of the present invention have the formula I ##STR1## wherein R1 is hydrogen or bromine, R2 is hydrogen or bromine, wherein at least one of R1 or R2 is bromine, R3 is hydrogen; Me2	09/23/1997
5318963	Heterocyclic hydrazide derivatives of monocyclic ଲ-lactam antibiotics Antibacterial activity has been found in compounds of the formula. Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene; Q completes a 5- or 6-membered saturated or unsaturated (including ...	06/07/1994
5290929	Heteroaryl derivatives of monocyclic beta-lactam antibiotics Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R1, R2, and M are as defined herein and X is --(CH2)n -- wherein n is 0, 1, 2, 3 or 4 or CR3 R4 ...	03/01/1994
5254681	Process for preparing monobactames and their intermediate product There is described a process for preparing monobactames of formula: ##STR1## where R=acyl, and their pharmaceutically acceptable salts, starting from ethyl (S)-3-hydroxybutanoate through the reaction intermediate (3S, 4R)-3-hydrazino-4-methyl-2-oxo-1...	10/19/1993
5250676	Process for the preparation of 3-substituted-2-azetidinones Provided is a process for diastereoselectively preparing compounds of the formula ##STR1## which includes the step of subjecting a compound of the formula ##STR2## to a salt whose anion is a nucleophilic base whose conjugate acid has a pKa ...	10/05/1993
5250525	4-oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I ##STR1## wherein: R1 =hydrogen, halogen, phenylacetamido; R2 =hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-...	10/05/1993
5229381	Substituted azetidinones as anti-inflammatory and antidegenerative agents New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. ##STR1##...	07/20/1993
5143913	[3S(Z)]-3-[[(2-amino-4- thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acetyl]amino]-2,2-dimethyl -4-oxo-1-azetidinyl sulfate The compound [3S(Z)]-3-[[(2-amino-4-thiazolyl)[[2-(hydroxyamino)-2-oxoethoxy]imino]acet yl]amino]-2,2-dimethyl-4-oxo-1-azetidinyl sulfate has gram-positive and gram-negative activity and good oral absorption....	09/01/1992
5120729	Beta-lactams as antihypercholesterolemics This application relates to compounds of formula (I), which are useful as antihypercholesterolemic agents. ##STR1##...	06/09/1992
5112968	Monobactam hydrazide derivatives Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof which possess antibacterial activity. Rs is a substituted hydroxy pyridone of the formulae: ##STR2## wherein Y1 is CH2 X; COOR	05/12/1992
5110812	Azetidin-2-one derivatives as serine protease inhibitors The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and an amino protecting group; n is 1 to 3; X is a membe...	05/05/1992
5106968	Process for bicyclic ଲ-lactams diazo-ଲ-keto-butyrate-intermediates for bicyclic ଲ-lactams 1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C2 -C10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-subs...	04/21/1992
5057512	3-amino-2-oxo-azetidine-1-sulfonic acids Novel syn isomers of reacemates and optical isomers of 3-amino-2-oxo-azetidine-1-sulfonic acids of the formula ##STR1## wherein R is difluoromethyl, R1 is --(CH2)n --X, n is an integer from 1 to 4, X is selected from ...	10/15/1991
5051502	Rhodium catalyzed cyclization process for bicyclic ଲ-lactams 1-Carbapenam-2-one-3-carboxylic acid and 1-carba-3-hydroxy-3-cephem-4-carboxylic acid and esters thereof are provided by a process comprising a rhodium C2 -C10 carboxylate catalyzed cyclization of an ester of a 4-(1-alkoxy- or 1-subs...	09/24/1991
5037819	Azetidin-2-one derivatives as serine protease inhibitors The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and an amino protecting group; n is 1 to 3; X is a membe...	08/06/1991
5030724	Monobactam hydrazides containing catechol sulfonic acid groups Antibacterial activity is exhibited by novel compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof. R3 and R4 are the same or different and each is hydrogen or alkyl or R3 and R4 ...	07/09/1991
4992544	Monocyclic beta-lactams and process for the preparation thereof Monocyclic ଲ-lactam compounds represented by the formula ##STR1## wherein R1 is H, NH2, acylamino, C1 -C4 alkyl, etc.; R2 is e.g. C1 -C4 alkyl, hydroxyalkyl, aminoalkyl, ca...	02/12/1991
4983597	Beta-lactams as anticholesterolemic agents Compounds of formula (I), which are useful as antihypercholesterolemic agents, are disclosed. ##STR1##...	01/08/1991

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Class 540/355 - The additional chalcogen is bonded directly to the ring nitrogen