Class 540/353 - Double bond between ring members of the five-membered hetero ring

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain a double bond between ring members
No. of patents: 34
Last issue date: 11/30/1999

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Number	Title	Issue Date
5994345	Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Carbapenems substituted with a naphthosultam at position 2 and linked through a CH2 group are disclosed. Pharmaceutical compositions and methods of treatment are also included. The naphthosultam is substituted with at least one cationic group -...	11/30/1999
5770729	Ozonide reducing agent The present invention provides an ozonide reducing agent for use in the ozonolysis reaction of an organic compound, the ozonide reducing agent finding wide applications, and being safe and inexpensive from a commercial viewpoint and easy to treat for disp...	06/23/1998
5721360	Process for the preparation of a thiazoline-azetidinone The present invention refers to process for the preparation of a tiazoline-azetidinone of formula I ##STR1## which comprises N-protecting in position 1 of (3S,4S)-3-phenylace tamido-4-acetoxy-azetidin-2-one, converting the product thus obtained into ...	02/24/1998
5288860	Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R3...	02/22/1994
5206361	Thiazolinoazetidinone derivative The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R3...	04/27/1993
4824849	଱₂ -adrenoceptor antagonistic arylquinolizines Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, plat...	04/25/1989
4810788	Azetidinone disulfide derivatives and a process for preparing the same An azetidinone derivative represented by the formula (I) ##STR1## wherein R1 is substituted or unsubstituted phenyl or substituted or unsubstituted phenoxy, R2 is hydrogen, optionally substituted hydrocarbon residue or aminoprot...	03/07/1989
4710504	Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective 댒 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, plat...	12/01/1987
4656264	Bicyclic azetidinone intermediates An azetidinone compound represented by the formula ##STR1## wherein R1 represents a substituted or unsubstituted phenyl group, R2 represents a carboxyl-protecting group, X represents a hydrogen atom or chlorine atom and Y repres...	04/07/1987
4603014	Thiazolinoazetidinone derivatives and process for the preparation of the same This invention provides thiazolinoazetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The thiazolinoazetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful ...	07/29/1986
4587048	Process for the manufacture of 4-thioazetidinone compounds The present invention relates to a novel process for the manufacture of 4-thioazetidinone compounds of the formula ##STR1## in which R1a represents an amino-protecting group and R1b represents hydrogen or a...	05/06/1986
4566996	Process for preparing azetidinone derivatives A process for preparing an azetidinone derivative represented by the formula (1) ##STR1## wherein R1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted phenylmethyl group or a substituted or unsubstit...	01/28/1986
4532077	Thiazolineazetidinone-type compounds This invention relates to novel thiazolineazetidinone-type compounds represented by the formula ##STR1## wherein R represents a hydrogen atom, alkyl group, alkyl group replaced with halogen atoms, methyl group replaced with substituted or unsubs...	07/30/1985
4518531	Allylic chlorination process and compounds prepared thereby This invention provides a novel allylic chlorination process for inserting a chlorine atom on the saturated methyl group of a 3-methyl-2-but-3-enoate group on the ring nitrogen atom of a 2-azetidinone or thiazolinoazetidinone. The chloro-substituted compo...	05/21/1985
4513134	Method of preparation of 3-methylene cepham compounds A method for the preparation of 3-methylene cepham compounds which comprises reacting 3-halomethyl butenoate derivatives of thiazolinoazetidinone with an aqueous acid solution in a mixed organic solvent....	04/23/1985
4497738	Analogous compounds of cephalosporins, processes for the preparation thereof and pharmaceutical composition comprising the same The invention relates to novel compounds of high antimicrobial activity, and to novel intermediates for the preparation of said compounds, said intermediates being of the formula: ##STR1## in which W is a protective amino group and Y is --S--Ag or --...	02/05/1985
4482491	Thiazolinoazetidinone derivatives and process for the preparation of the same This invention provides thiazolinoazetidinone derivatives represented by the formula ##STR1## and processes for preparing the same. The thiazolinoazetidinone derivatives are used as the intermediates for producing cephalosporin compounds useful ...	11/13/1984
4430268	Allylic chlorination process This invention provides a novel allylic chlorination process for inserting a chlorine atom on the saturated methyl group of a 3-methyl-2-but-3-enoate group on the ring nitrogen atom of a 2-azetidinone or thiazolinoazetidinone. The chloro-substituted compo...	02/07/1984
4392923	Process for preparing thiazolinozetidinone derivatives This invention provides a process for preparing a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R1 represents aralkyl group or aryloxymethyl group and R2 represents acyl group, the process comprisi...	07/12/1983
4339449	Analogous compounds of cephalosporins, and pharmaceutical composition comprising the same A compound of high antimicrobial activity of the formula: ##STR1## in which R1 is amino or a substituted amino group and R2 is hydrogen or lower alkoxy, or R1 and R2 are combined together to form a group of the formu...	07/13/1982
4332722	Cyclization to form cephem ring and intermediates therefor An intermediate represented by the following formula, for synthesizing --3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy...	06/01/1982
4230619	Synthetic routes to azetidinones related to nocardicin There is disclosed a process for the manufacture of azetidinones related to nocardicin having the formula ##STR1## wherein R is a saturated or unsaturated alkyl having from 1 to 6 carbon atoms, ଱-aminobenzyl, benzyl, free or substituted phenyl,...	10/28/1980
4226986	Process for halogenation of ଲ-lactam compounds Novel halogenating compounds, derived from triaryl phosphites and chlorine or bromine are employed to convert 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives. The product 3...	10/07/1980
4193917	Chemical compounds Novel semisynthetic ଲ-lactam intermediates of use in the production of cephalosporins, penicillins and related ଲ-lactam antibiotic compounds are provided. The novel compounds are prepared from ଲ-lactams obtained by cleavage of the 1,2-su...	03/18/1980
4172078	Thiazolineazetidinone derivatives Thiazolineazetidinone derivatives of the formulae 1,2, and 3. ##STR1## wherein R is derived from the commonly known carboxamido groups present in penicillins, R1 is a carboxy protecting group commonly used in penicillin chemistry, and R	10/23/1979
4171304	2-Iodomethylpenams Novel 2-iodomethyl-penicillanic acid derivatives are prepared and are useful for the preparation of bioactive 2,3-methylenepenams and 2-methylceph-3-ems....	10/16/1979
4160091	Process for preparation of 3-halo-3-methylcephams 3-Halo-3-methylcephams and 2-halomethylpenams are prepared by the reaction of novel azetidinone mercuric sulfides with positive halogenating agents. 3-Halo-3-methylcephams are useful as intermediates to known desacetoxy cephalosporin antibiotics....	07/03/1979
4155911	Process for the production of substituted 4-thia-2,6-diaza[3.2.0]-2-heptene-7-one A new process is disclosed for the preparation of compounds of structure: ##STR1## and are as defined herein characterized in that a compound of structure ##STR2## where R and R1 have the meanings given herein, is reacted in a suitabl...	05/22/1979
4130557	Method for the hydrolysis of azetidinothiazoline compounds A process for preparing compounds having the formula: ##STR1## WHEREIN R is phenoxymethyl or benzyl; R2 is 1-methoxyethylidene, 1-hydroxyethylidene, or 1,1-dimethoxyethylidene; and R3 is trichloroethyl, diphenylmethyl, p-nitrobenzyl,...	12/19/1978
4108861	Azetothiazole-5-yl-3-halomethyl-2-butenoic acid derivatives and the preparation of 5-thia-1-azabicyclo-[4.2.0]-2-octene-2-carboxylic acid derivatives from them A compound of the formula ##STR1## wherein R1 is lower alkyl, aryloxy(lower)alkyl or ar(lower)alkyl, R2 is lower alkyl, Coor3 is esterified carboxy selected from lower alkoxycarbonyl and ar(lower)alkoxycarbonyl, X is halog...	08/22/1978
4091026	Thiazoleneazetidinones from dithiazeneazetidinones An improved process for preparing 4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-ones such as methyl 3-phenoxy-4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-one-6-isopropenylacet ate which comprises extruding sulfur from dithiazeneazetidinones such as methyl...	05/23/1978
4079181	Certain 7-oxo-4-thio-2,6-diazabicyclo-3,2,0-hept-2-ene compounds An intermediate represented by following formula for synthesizing 3-hydroxy-3-cephem compounds. ##STR1## wherein A and B each is a hydrogen or amino substituent; R is a hydrogen or thiol substituent; Hal is a halogen; X is a hydroxy or carboxy p...	03/14/1978
4077970	Methyl-଱[3'acetoxy-1'isopropenyl]-3 substituted 1଱,5x-4-thia 2,6 diaza[3,2,0]2-heptene-6 acetate 7-one A process is disclosed for the preparation of a compound of the formula ##STR1## where R and R1 are defined herein below, wherein a compound of the structure; ##STR2## is reacted in a suitable solvent with a haloamide in the presence ...	03/07/1978
3991069	Certain thiazolo azetidinone compounds Novel semisynthetic ଲ-lactam intermediates of use in the production of cephalosporins, penicillins and related ଲ-lactam antibiotic compounds are provided. The novel compounds are prepared from ଲ-lactams obtained by cleavage of the 1,2-su...	11/09/1976

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Class 540/353 - Double bond between ring members of the five-membered hetero ring