Quotables
"For a list of all the ways technology has failed to improve the quality of life, please press three."
Alice Kahn
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8148520 | Process for the preparation of beta-lactam antibiotic meropenem trihydrate A process for preparing purified Meropenem trihydrate that involves the dissolution of Meropenem in water in presence of base, adjusting the pH to 4.0-7.0, and adding solvent to yield Meropenem trihydrate. ... | 04/03/2012 |
| 8097719 | Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem The present invention relates to novel crystalline form of (4-Nitrobenzyl (4R,5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl}thio-6-[(1R)-1-hydorxyehtyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0].hept-2-ene-2-carboxylate) of com... | 01/17/2012 |
| 8093378 | Crystallization method for intermediates of carbapenem antibiotics An improved crystallization method for an azetidinone compound represented by the formula 1: , which is extremely useful as a common intermediate for the synthesis of 1β-methylcarbapenem compounds.... | 01/10/2012 |
| 7932381 | Process for producing carbapenem derivative and intermediate crystal therefor An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, c... | 04/26/2011 |
| 7767809 | Crystal of intermediate for carbapenem The disclosed invention relates to a solvate of the compound (I) of the formula: or a crystal thereof. ... | 08/03/2010 |
| RE40794 | Crystalline forms of carbapenem antibiotics and methods of preparation A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solut... | 06/23/2009 |
| 7524952 | Process for producing carbapenem compound for oral administration The present invention provides a process for efficiently producing a 1β-methylcarbapenem compound for oral administration. The process, which is for producing a 1β-methylcarbapenem compound represented by general formula (2), is characterized by reacting a β-lact... | 04/28/2009 |
| 7507814 | Process for preparation of imipenem The invention provides a novel compound of Formula II which is useful in the preparation of imipenem monohydrate of Formula I, wherein R1 is a p-nitrobenzyl or p-methoxybenzyl group; and R2 and R3 may be identical to or different from each other and are each indepen... | 03/24/2009 |
| 7462712 | Process for the preparation of imipenem The present invention relates to an improved process for the preparation of imipenem comprising reacting a bicyclo ketone precursor of the Formula II, wherein R is a protecting group, with a phosphorohalidate in the presenc... | 12/09/2008 |
| 7381724 | Optically active 5H-pyrrolo[3,4-b]pyrazine derivative, its preparation and pharmaceutical compositions containing same Dextrorotatory isomer of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, its preparation and pharmaceutical compositions containing it which are usable as tranquillisers and hypnotics. ... | 06/03/2008 |
| 7342005 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 ... | 03/11/2008 |
| 7332600 | Process for the preparation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the re... | 02/19/2008 |
| 7241885 | Process for the isolation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity comprising the steps of treating an aqueous solution containing imipenem with an organic solvent, wherein the imipenem is not lyoph... | 07/10/2007 |
| 7205291 | Carbapenem compounds A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr... | 04/17/2007 |
| 7192963 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3. ... | 03/20/2007 |
| 7163936 | β-lactam compounds and process for producing the same 1. A β-lactam compound of the formula [1]; wherein R1 is a lower alkyl, a lower alkyl substituted by a hydroxy; R2 is a hydrogen, a lower alkyl; X is O, S, NH; m and n are 0 to 4, Y1 | 01/16/2007 |
| 7157576 | Crystalline acid salts of cefdinir and process for preparing cefdinir using same High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdi... | 01/02/2007 |
| 7145002 | Crystalline forms of carbapenem antibiotics and methods of preparation A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling th... | 12/05/2006 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7084268 | Carbapenem compound crystals and interjection preparations The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it p... | 08/01/2006 |
| 7078534 | Process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (imipenem monohydrate) The present invention relates to a cost effective and commercially viable process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (Imipenem monohydrate) of Formula I. ... | 07/18/2006 |
| 7071330 | Process for carbapenem synthesis A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed. ... | 07/04/2006 |
| 7041836 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 | 05/09/2006 |
| 7041660 | Crystalline 1-methylcarbapenem derivatives This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against vari... | 05/09/2006 |
| 7034150 | Processes for the preparation of carbapenem-type antibacterial agents A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparati... | 04/25/2006 |
| 7022841 | Process for making carbapenem compounds The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I: or a salt thereo... | 04/04/2006 |
| 7001897 | 1-methylcarbapenem derivatives A 1-methylcarbapenem compound represented by the formula (I): having antibacterial activity, pharmacologically acceptable esters or salts thereof and pharmaceutical compositions (particularly antibacterial agents) cont... | 02/21/2006 |
| 6962993 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3. ... | 11/08/2005 |
| 6960585 | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R | 11/01/2005 |
| 6924279 | Crystalline 1-methylcarbapenem derivatives This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent ... | 08/02/2005 |
| 6649756 | PROCESS IMPROVEMENT IN THE PREPARATION OF (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-AMINO-3-METHYL-1-OXOBUTYL]AMINO]METHYL]TETRAHYD RO-3-FURANYL]THIO]-6-[(R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3.2. 0]HEPT-2-ENE-2-CARBOXYLIC ACID The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydr o-3-furanyl]thio]-6-[R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2. 0]hept... | 11/18/2003 |
| 6642377 | Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: ##STR1## wherein the ring A means the basic antibiotic; R10 means a protected func... | 11/04/2003 |
| 6599895 | ଲ-lactam compounds and process for producing the same Novel ଲ-lactam compound of the formula [1]: ##STR1## wherein R1 is lower alkyl or hydroxy-substituted lower alkyl, R2 is H or lower alkyl, X is O or, S, R3 is H, metal or protecting group, W is a 6- or 7-membered nit... | 07/29/2003 |
| 6589952 | Imidazo[1,2-a]pyrazines for the treatment of neurological disorders Provided herein are novel imidazo[1,2-a]pyrazines of Formula I: ##STR1## wherein: X is CHR5, NR5, O, S, S(O)n or a single bond, wherein n is equal to 0, 1 or 2; D is aryl or heteroaryl attached through an unsaturated carbon ato... | 07/08/2003 |
| 6548492 | Process for formulation of carbapenem antibiotic compositions A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: ##STR1## The process entails compounding a unst... | 04/15/2003 |
| 6531594 | Process for producing 1H-3-aminopyrrolidine and derivatives thereof A process for producing 1H-3-aminopyrrolidine and derivatives thereof is disclosed. The process is especially useful for producing optically active 1H-3-aminopyrrolidine and derivatives thereof and in this case comprises reacting an optically active amino... | 03/11/2003 |
| 6504027 | Decarboxylation process for synthesizing carbapenem antibiotics A process for the direct crystallization of a compound of the formula I: ##STR1## or a pharmaceutically acceptable salt thereof, is disclosed, wherein R1 and R2 represent H, C1-10 alkyl, aryl or heteroaryl, or substituted ... | 01/07/2003 |
| 6486150 | Process for formulation of antibiotic compounds The present invention involves a process for preparing a stable final formulation product of a compound of formula I, ##STR1## or its pharmaceutically acceptable salt, hydrate or solvate by incorporating a suitable carbon dioxide source to an unstable mon... | 11/26/2002 |
| 6482818 | C-2 S/O-and S/N formaldehyde acetal derivatives of carbapenem-3-carboxylic acids and their use as antibiotics and ଲ-lactamase inhibitors The compounds of the general formula I ##STR1## wherein R1 denotes hydrogen, hydroxymethyl or 1-hydroxyethyl, R2 denotes hydrogen or methyl and R3 denotes a pharmaceutically acceptable group which is bonded to the remainin... | 11/19/2002 |
| 6479478 | Carbapenem compounds It is provided carbapenem compounds represented by the following formula (I): ##STR1## wherein R is hydrogen atom, or substituted or unsubstituted lower alkyl group; and, n is an integer of 1 or 2, or a pharmaceutically acceptable salt thereof, and an antibact... | 11/12/2002 |
