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| Number | Title | Issue Date |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7087748 | Process A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selectiv... | 08/08/2006 |
| H2158 | Process for the production of clavulanic acid salts Use of the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid as an intermediate in the production of pharmaceutically acceptable salts of clavulanic acid. ... | 06/06/2006 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6566106 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 05/20/2003 |
| 6465491 | 6-phenylpyridyl-2-amine derivatives The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central ner... | 10/15/2002 |
| 6417352 | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid The invention relates to the process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid from a fermentation broth containing impure clavulanic acid comprising the steps of filtration of the fermented broth, extraction ... | 07/09/2002 |
| 6414142 | Process for preparing potassium clavulanate A new crystalline form of potassium clavulanate is disclosed. Also disclosed are a process for producing the new crystalline form of potassium clavulanate, pharmaceutical compositions containing it and methods of treating bacterial infections.... | 07/02/2002 |
| 6369219 | Preparation of clavulanate salts Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; i... | 04/09/2002 |
| 6300495 | Process for the preparation of a metal salt of clavulanic acid A process for the preparation of a metal salt of clavulanic acid which comprises the reaction between an organic amine salt of clavulanic acid and a metal salt precursor compound, the reaction taking place in a liquid medium which comprises a liquid flori... | 10/09/2001 |
| 6235747 | 6-phenyl-pyridin-2-ylamine derivatives The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central ner... | 05/22/2001 |
| 6235506 | Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.... | 05/22/2001 |
| 6218380 | Pharmaceutical compositions A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic ac... | 04/17/2001 |
| 6207428 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 03/27/2001 |
| 6180782 | Preparation of clavulanate salts Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; i... | 01/30/2001 |
| 6172221 | Clavulanic acid extraction process A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and shear stress.... | 01/09/2001 |
| 6133441 | Production of a salt of clavulanic acid Process for the production of alkali salts of clavulanic acid of formula ##STR1## by conversion of clavulanic acid into a pharmaceutically acceptable salt of clavulanic acid which is characterised in that the conversion is carried out in n-butanol or... | 10/17/2000 |
| 6051703 | Purified clavulanic acid and salts thereof A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulan... | 04/18/2000 |
| 6048977 | Clavulanic acid and salts thereof A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulan... | 04/11/2000 |
| 6031093 | Solid salts of clavulanic acid A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulan... | 02/29/2000 |
| 5994534 | Process for the preparation of pharmaceutically acceptable salts of clavulanic acid Provided is a process for preparation of pharmaceutically acceptable metal salts of clavulanic acid which avoids the use of toxic amines or other intermediates. The process involves removing solids from a clavulanic acid containing fermentation broth by m... | 11/30/1999 |
| 5985625 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without pr... | 11/16/1999 |
| 5985624 | Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.... | 11/16/1999 |
| 5965728 | Process for the preparation of a salt clavulanic acid A process for the preparation of a salt of clavulanic acid, wherein clavulanic acid in solution in a wholly or partly water-imiscible organic solvent is contacted in a region of high turbulence and/or shear stress, with a salt precursor compound to form a... | 10/12/1999 |
| 5859238 | Alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof A process for purification of crude clavulanic acid and its subsequent conversion to its potassium salt. A crude clavulanic acid extract is contacted in an organic solvent with an alkylenediamine of the formula II ##STR1## wherein the substituents R | 01/12/1999 |
| 5821364 | Diamine salts of clavulanic acid New diamine salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.... | 10/13/1998 |
| 5786351 | Clavulanic acid salts A di-clavulanate salt derived from clavulanic acid and a diamino ether of the formula ##STR1## wherein R1 is an alkylene group, optionally having one or more inert substituents: and each of R2 and R3 is a hydrogen ato... | 07/28/1998 |
| 5760218 | Diamine salts of clavulanic acid New diamine salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.... | 06/02/1998 |
| 5750685 | Process for preparing potassium clavulanate in rossette form A process is disclosed for preparing potassium clavulanate in the form of crystalline rosettes by addition of a solution of clavulanate ions to a solution of potassium ions in a non-solvent for potassium clavulanate.... | 05/12/1998 |
| 5741903 | Diamine salts for purification of clavulanic acid A process for the purification of clavulanic acid comprising reacting in an organic solvent impure clavulanic acid with a diamine of the formula ##STR1## wherein R1, R2, R3 and R4 are individually selected ... | 04/21/1998 |
| 5734048 | Process for manufacturing clavulanic acid salt According to the present invention, a process for manufacturing alkali metal salt of clavulanic acid wherein impure clavulanic acid in aqueous solution is extracted by a solvent mixture of ketone and alkyl acetate under acidic condition, treated in a conv... | 03/31/1998 |
| 5726170 | Clavulanic acid salts The salts are prepared by reacting a benzhydrylamine of the formula I (or a salt thereof) with clavulanic acid (or a salt thereof) in solvent, and isolating the resulting salt. In formula I, each of R1 and R2 is hydrogen (preferred) ... | 03/10/1998 |
| 5719277 | Diamine salts of clavulanic acid New diamine mono and diamine di salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.... | 02/17/1998 |
| 5679789 | Pharmaceutical compositions comprising potassium clavulanate and methods of using them Potassium clavulanate exists in a novel crystalline habit, namely in the form of rosettes, having improved processing properties. The novel form may, for example, be obtained by crystallization or recrystallization using inverse precipitation, preferably ... | 10/21/1997 |
| 5670638 | 2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, and preparation The azetidines of the present invention have the formula I ##STR1## wherein R1 is hydrogen or bromine, R2 is hydrogen or bromine, wherein at least one of R1 or R2 is bromine, R3 is hydrogen; Me2 | 09/23/1997 |
| 5608052 | Inclusioin complexes of clavulanic acid and of alkali salts thereof with hydrophilic and hydrophobic beta-cyclodextrin derivatives, a process for the preparation thereof and the use thereof Described is a new process for the preparation of alkali clavulanate from an aqueous solution of crude clavulanic acid, which is obtained in a conventional manner after the fermentation with a clavulanic-acid-producing microorganism, extracted with an eth... | 03/04/1997 |
| 5585373 | 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a b... | 12/17/1996 |
| 5498788 | Inclusion complexes of clavulanic acid and of potassium salts thereof with hydrophobic ଲ-cyclodextrin derivatives a process for the preparation thereof Described is a new process for the preparation of alkali clavulanate from an aqueous solution of pure clavulanic acid and of pharmaceutically acceptable potassium crude clavulanic acid, which is obtained in a conventional manner after the fermentation wit... | 03/12/1996 |
| 5310898 | Alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof A novel process for the preparation of calvulanic acid and pharmaceutically acceptable salt thereof, such as potassium clavulanate, is described. According to the novel process, crude clavulanic acid, which is present in the form of an extract in an organ... | 05/10/1994 |
