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| Number | Title | Issue Date |
| 6433163 | Combined supported liquid membrane/strip dispersion process for the removal and recovery of penicillin and organic acids The present invention provides a novel process for the removal and recovery of penicillin and organic acids from process streams and waste waters. The process of the present invention utilizes a combination of a supported liquid membrane (SLM) and a strip... | 08/13/2002 |
| 5801242 | Process for making quinolonyl lactam antimicrobials and novel intermediate compounds The present invention provides processes for making compounds of the structure (Q--L1)--L--(L2 --B) wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiet... | 09/01/1998 |
| 5532232 | Guanidine derivatives Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The co... | 07/02/1996 |
| 5281703 | Process for making antimicrobial quinolonyl lactams The present invention provides methods of making compounds of the structure [Q-L1 ]-L-[L2 -B[ wherein (I) Q is a quinolone moiety; (II) B is a beta-lactam moiety; (III) L, L1, and L2 together comprise a carbamate-containing ... | 01/25/1994 |
| 4933444 | Process for preparing 2ଲ-substituted-methylpenicillin derivatives Disclosed is a process for preparing 2ଲ-substituted-methylpenicillin derivative of the formula ##STR1## wherein R is H or carboxyl protecting group, R1 is H or halo, R2 is H, lower alkyl, lower alkoxy, halogen, azido, lowe... | 06/12/1990 |
| 4877783 | ଲ-lactam antibacterial agents ଲ-Lactam antibiotics having an -formamido substituent on the carbon atom adjacent to the carbonyl group of the ଲ-lactam ring and in particular bicyclic compounds having the partial structure: ##STR1## Intermediates and processes fo... | 10/31/1989 |
| 4831025 | Crystalline penicillin derivative tosylate hydrates The present invention relates to a crystalline hydrate of a salt of the antimicrobial agent 1,1-dioxopenicillanoyloxymethyl 6-(D--amino--phenylacetamido)penicillanate with p-toluenesulfonic acid, more particularly the mono- and dihydrate. Th... | 05/16/1989 |
| 4675398 | Copper-mediated oximation reaction The presence of a copper salt during the oximation of a ଲ-lactam containing compound having glyoxylamino substituents of the formula ##STR1## by reaction with an aminooxy compound having the formula or a salt or ester thereof, results in a product w... | 06/23/1987 |
| 4626532 | Process for stabilization of bacampicillin hydrochloride A new process for the stabilization of bacampicillin hydrochloride against degradation by humidity characterized by the incorporation of between 3 to 9% by weight of straight-chain alkanes, alkenes, fatty acids, alcohols, and esters of fatty acids and alc... | 12/02/1986 |
| 4606865 | Methods for the preparation of -bromodiethylcarbonate The novel compound -bromodiethylcarbonate, novel methods for the preparation thereof, its use in the preparation of 1-ethoxycarbonyloxyethyl esters of penicillins and cephalosporins, and improvements in the method for preparing such esters.... | 08/19/1986 |
| 4447602 | Process to prepare 7-substituted cephalosporins or 6-substituted penicillins A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypoc... | 05/08/1984 |
| 4410458 | Process for providing an oxidized penam This invention relates to a process for preparing an oxidized penam derivative of the formula: ##STR1## wherein R1 represents an amino or protected amino radical, and R3 represents a radical selected from the group consisting of carb... | 10/18/1983 |
| 4407751 | Processes for preparing ଲ-lactams The present invention relates to hitherto unknown compounds of the general formula I: ##STR1## in which R1 stands for a phenyl, 4-hydroxyphenyl, 1,4-cyclohexadienyl or a 3-thienyl group; R2 represents a primary amino or a carbox... | 10/04/1983 |
| 4304717 | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamine, trialkylsi... | 12/08/1981 |
| 4255330 | Process for preparing 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acid Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R1 is hydrogen or acyl, R2 is hydrogen or methoxyl, and R3 is, inter alia, hydrogen, --R, --OR, ... | 03/10/1981 |
| 4171303 | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives This invention relates to a process for the preparation of acid amides having the formula (I) or their salts ##STR1## wherein R1 is hydrogen or an easily removable ester-forming or salt-forming group, preferably a trialkylamino, trialkylsi... | 10/16/1979 |
| 4111933 | Protection of functional groups during reaction and their subsequent restoration In the process for preparing an organic compound of the formula in which X is an amino group, a hydroxyl group or a carboxyl group, and A' is the remainder of the molecule, from an organic compound of the formula in which A is the remainder of the molecule which ca... | 09/05/1978 |
| 4072676 | Process for preparation of 6-aminopenicillanic acid derivatives A process for the preparation of 6-aminopenicillanic acid is described which comprises reacting a natural penicillin with a phosphorus halide to protect the carboxyl group of the natural penicillin and thereafter reacting the protected penicillin with an ... | 02/07/1978 |
| 4062842 | Method for preparing 7-substituted cephalosporins and 6-substituted penicillins by replacement of sulfur-containing groups Disclosed is a method for replacing 7-lower alkylthio and 7-arylthio groups from cephalosporins with lower alkanoyloxy,lower alkoxy, aryloxy, aroyloxy, amino, lower alkylamino and azido moieties, and for replacing 6-lower alkylthio and 6-arylthio groups f... | 12/13/1977 |
| 4041029 | Acylimine cephalosporins A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypoc... | 08/09/1977 |
| 4008220 | Penicillins A penicillin of the formula: ##STR1## wherein ##STR2## is a six-membered heteroaromatic ring containing 1 or 2 nitrogen atoms as the hetero atom, Y is hydrogen, lower alkanoyl or lower alkoxycarbonyl, R1 and R2 are eac... | 02/15/1977 |
| 3962214 | Process for preparing amino substituted ଲ-lactam antibiotics 6-Acylamino-6-alkylthiopenicillanic or 7-acylamino-7-alkylthiocephalosporanic acids or esters are reacted at a temperature between -80° and -25°C. with one equivalent of halogen to provide an intermediate halosulfonium halide which is reacted with ... | 06/08/1976 |
| 3962215 | Intermediates for preparing semi-synthetic penicillins and processes relating thereto Phosphorylated penicillins and cephalsporins are described which are obtained by reacting a penicillin or cephalo porin with a trivalent or pentavalent phosphorus halide and treating the thus formed product sequently with an acid chloride, an alcohol and ... | 06/08/1976 |
