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| Number | Title | Issue Date |
| 7977475 | Process for the preparation of faropenem The present invention is related to processes for the preparation of faropenem, which comprises treating the compound of Formula II, with an alkali metal salt of a substituted or unsubstituted C5-10 carboxylic ac... | 07/12/2011 |
| 7714125 | Process for producing penam compound useful for preparing tazobactam An object of the invention is to provide an industrially advantageous process capable of remarkably suppressing the generation of an undesirable by-product cepham compound to thereby efficiently produce a desired 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-... | 05/11/2010 |
| 7692003 | Penicillin crystals and process for producing the same The present invention provides 2β-chloromethyl-2α-methylpenam-3α-carboxylic acid benzhydryl ester (CMPB) crystals of excellent stability, and a process for producing the CMPB crystals comprising the steps of (A) concentrating a solution containing CMPB; (b) subje... | 04/06/2010 |
| 7674898 | Anhydrous crystal of β-lactam compound and method for preparation thereof The present invention provides anhydrous crystals of β-lactam compound represented by the formula: The β-lactam compound of the invention is produced by heating an aqueous solution of a salt of the β-lactam compound and ... | 03/09/2010 |
| 7547777 | Penam crystals and process for producing the same The present invention provides novel 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid benzhydryl ester (TMPB)-acetone crystals for use in the production of 2α-methyl-2β-[(1,2,3-triazol-1-yl)methyl]penam-3α-carboxylic acid 1,1-dioxide benzhydry... | 06/16/2009 |
| 7514553 | Process for producing penicillanic acid compound A process for preparing a penicillanic acid compound of the formula (2) comprising reacting a halogenated penicillanic acid compound of the formula (1), (a) in the presence of a metal bismuth or bismuth compound, (b) with a metal having a lower standard oxidation-re... | 04/07/2009 |
| 7459551 | Method for preparing cyclic compounds The present invention provides a method for preparing a β-lactam compound of the following Formula (3), which comprises the step of reacting a compound of the following Formula (1) with a trialkyl phosphite represented by the formula (R5O)3P (... | 12/02/2008 |
| 7417143 | Process for the preparation of Tazobactam in pure form An improved process for the purification of tazobactam or its derivatives of the formula (I) wherein R represents hydrogen, C1-C6alkyl, p-methoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, o-chlorobenzyl, be... | 08/26/2008 |
| 7358356 | Processes for preparation of organic compounds The present invention provides a method for preparing an organic compound, which comprises a dehydration step of distilling off water from a polar organic solvent solution containing the organic compound and water to bring the concentration of water below a given le... | 04/15/2008 |
| 7273935 | Process for the preparation of 3-methylcepham derivatives A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein R2 and R3 may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido, sub... | 09/25/2007 |
| 7125986 | Penicillanic acid derivative compounds and methods of making Compounds of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for in... | 10/24/2006 |
| 7112582 | Bicyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B den... | 09/26/2006 |
| 7091197 | Beta-lactamase inhibitor prodrug Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of t... | 08/15/2006 |
| 7071330 | Process for carbapenem synthesis A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed. ... | 07/04/2006 |
| 7018997 | Tricyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof. wherein one of A and B denotes hy... | 03/28/2006 |
| 6936711 | Process for preparation of penam derivatives from cepham derivatives The present invention relates to a process for preparing 2α-methyl-2β-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2β-heterocyclyl methyl penam derivatives of the form... | 08/30/2005 |
| 6916801 | 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β... | 07/12/2005 |
| 6906054 | Compositions for inhibiting beta-lactamase The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R1-R11 and A have any of the values defined in the specification, and ... | 06/14/2005 |
| 6770759 | Penicillanic acid derivative compounds and methods of making Compound of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ... | 08/03/2004 |
| 6660855 | Crystals of penicillin and process for the production thereof The crystal of the invention is crystal of diphenylmethyl 2-methyl-2-triazolylmethylpenam-3-carboxylate which is stable substantially without decomposition or degradation of properties even when left to stand at room temperature for 1 year. The crystal of... | 12/09/2003 |
| 6600035 | 6-(substituted methylene) penems and intermediates ##STR1## Compounds of formula (I) in which: R1 is hydrogen or an organic substituent group; R2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R4 and R5 are independently hydrogen or ... | 07/29/2003 |
| 6495539 | B-lactam-like chaperone inhibitors Compounds of the formula ##STR1## and the salts, esters and amides thereof wherein Z is S, SO, SO2 or O; each of R1, R2 and R3 is independently H or substituted or unsubstituted alkyl (1-10C), substituted or unsubsti... | 12/17/2002 |
| 6437119 | Compounds formed from two or three antibiotics and their processes of preparation Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, ଲ-lactams and vancomycin and the like as the starting materials and chloride linking agents; and the novel compounds prepared by these proc... | 08/20/2002 |
| 6395726 | 3,6-disubstituted penam sulfone derivatives Compounds are provided having the following formulae I and II: ##STR1## wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group;... | 05/28/2002 |
| 6339152 | Process for producing exo-methylenepenam compounds The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up to -0.3 (V/SCE) in an amount of at least one mole per mole ... | 01/15/2002 |
| 6274730 | Process for producing halogenated ଲ-lactam compound A process for preparing halogenated ଲ-lactam compounds, characterized in that a ଲ-lactam amino compound of the formula (1) is reacted with nitrous acid or nitrite in a slurry dispersion state in water, under acid condition in the presence of h... | 08/14/2001 |
| 6271222 | Penem antibacterial compounds, compositions and methods of treatment The present invention relates to penem antibacterial agents in which the releaseable liphophilic aromatic side-chain, tethered to the carbapenem nucleus via a methylene linker, necessary for anti-MRSA activity replaces the non-releaseable liphophilic side... | 08/07/2001 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
| 6160112 | Procedure for the preparation of dioxopenicillanic acid derivatives Procedure for the preparation of dioxopenicillanic acid derivatives and its salts pharmaceutically acceptable with general formula I, where, R is hydrogen, alkyl group containing 1 to 5 Carbon atoms or a residue of type --CH2R', where R' is hydrogen, halo... | 12/12/2000 |
| 6156745 | 2ଲ-substituted-6-alkylidene penicillanic acid derivatives as ଲ-lactamase inhibitors Compounds of formula I: ##STR1## wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase en... | 12/05/2000 |
| 6150350 | Antimicrobial compositions The invention relates to antimicrobial compositions comprising a combination of (1) a therapeutically effective amount of a compound of formula I ##STR1## with (2) a second ingredient selected from carbapenem antibiotics or with ଲ-lactamas... | 11/21/2000 |
| 6043356 | Process for preparing ଲ-lactam compound The present invention provides a process for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a ଲ-lactam halide compound represented by the general formula (2) is reduced with a metal having a sta... | 03/28/2000 |
| 5886203 | Metalorganic compounds A process is provided for the production of metalorganic compounds by reacting a Grignard reagent with a Group II, Group III or Group V metal halide in a tertiary alkyl amine solvent to form a metalorganic adduct, isolating the adduct and dissociating the... | 03/23/1999 |
| 5885981 | Antibacterial penem esters derivatives Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R1 is a hydrogen atom or linear or branched C1 --C6 alkyl group... | 03/23/1999 |
| 5830889 | Antibacterial penem esters derivatives Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the general formula: ##STR2## in which R1 is a linear or branched C1 -C6 alkyl group, R2 is... | 11/03/1998 |
| 5821362 | Method of desilylating silylether compounds Method of desilylating a silylether compound by reacting a silylether compound of the general formula (I): ##STR1## or a salt thereof with an amine hydrogen fluoride salt or a pyridine hydrogen fluoride salt in an organic solvent to produce a compoun... | 10/13/1998 |
| 5801242 | Process for making quinolonyl lactam antimicrobials and novel intermediate compounds The present invention provides processes for making compounds of the structure (Q--L1)--L--(L2 --B) wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiet... | 09/01/1998 |
| 5763603 | Crystalline tazobactam, and its production and use Crystalline sodium 2-methyl-2ଲ-(1,2,3-triazol-1-yl) -methylpenam-3-carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated aqueous solution of sodium 2-methyl-2... | 06/09/1998 |
| 5747483 | Penem derivatives, their preparation and pharmaceutical compositions containing them Penem derivatives of general formula (I), below, and pharmaceutically acceptable salts thereof are disclosed. ##STR1## wherein: R1 is H, C1 -C6 alkoxy, C3 -C7 cycloalkyl, or an optionally protect... | 05/05/1998 |
| 5703068 | Penem compounds Antibiotic penem compounds are represented by the following formula: ##STR1## wherein R represents a group of the following formula: ##STR2## in which R1 is a linear or branched, C1 -C6 alkyl group, R2... | 12/30/1997 |
