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| Number | Title | Issue Date |
| 7355040 | Process for the preparation of cephalosporin compounds and synthetic intermediates There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclizing a compound of Formula (III): wherein R1, R... | 04/08/2008 |
| 7294512 | Solution for calibrating a chemical analyzer for alcohol, carbonate and ammonia assays A multi-analyte calibration solution having known amounts of sodium carbonate, ammonium bicarbonate, and ethyl alcohol, with pH adjusted within a range between about 7.8 and 8.4. ... | 11/13/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7273935 | Process for the preparation of 3-methylcepham derivatives A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I). wherein R2 and R3 may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido, sub... | 09/25/2007 |
| 7264943 | Method for producing cephalexin The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands having nucleophilic groups and is in bead form. ... | 09/04/2007 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7071330 | Process for carbapenem synthesis A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed. ... | 07/04/2006 |
| 6906054 | Compositions for inhibiting beta-lactamase The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R1-R11 and A have any of the values defined in the specification, and ... | 06/14/2005 |
| 6825344 | Process for the preparation of cephalosporin compounds and synthetic intermediates There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1... | 11/30/2004 |
| 6683176 | Intermediates for and synthesis of 3-methylene cephams The present invention relates to novel processes for the preparation of 3-methylenecephams. More specifically, the present invention relates to the intramolecular cyclization of penicillin sulfoxide derived monocyclic azetidinone derivatives with organome... | 01/27/2004 |
| 6620930 | Process for preparing 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfonic acid: ##ST... | 09/16/2003 |
| 6458558 | Process for the preparation of ଲ-lactam derivatives A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclosed in U.S. Pat. No.... | 10/01/2002 |
| 6437119 | Compounds formed from two or three antibiotics and their processes of preparation Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, ଲ-lactams and vancomycin and the like as the starting materials and chloride linking agents; and the novel compounds prepared by these proc... | 08/20/2002 |
| 6420554 | Process for preparation of 3-cephem compound A process for preparing a 3-cephem compound represented by the formula (3), the process comprising the steps of reacting a ଲ-lactam compound represented by the formula (1) with a phosphorus halide compound in the presence of an organic base to give ... | 07/16/2002 |
| 6407091 | ଲ-lactamase inhibiting compounds The invention provides compounds of formula I and IV: ##STR1## wherein R1 -R11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase enzyme... | 06/18/2002 |
| 6337396 | Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate A method for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethyl formamide solvate using a mixture of a lower alkanol and water.... | 01/08/2002 |
| 6303592 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 10/16/2001 |
| 6274730 | Process for producing halogenated ଲ-lactam compound A process for preparing halogenated ଲ-lactam compounds, characterized in that a ଲ-lactam amino compound of the formula (1) is reacted with nitrous acid or nitrite in a slurry dispersion state in water, under acid condition in the presence of h... | 08/14/2001 |
| 6255479 | Process for the preparation of -oxolactams A method for preparing an -oxolactam comprising, reacting a corresponding -diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding -oxolactam.... | 07/03/2001 |
| 6232305 | Substituted amino bicyclic-ଲ-lactam penam and cepham derivatives as cysteine protease inhibitors The present invention provides substituted amino bicyclic-ଲ-lactam penam derivatives and substituted amino bicyclic-ଲ-lactam cepham derivatives and their diastereoisomers of formula I, as well as compositions, methods of making, and methods of... | 05/15/2001 |
| 6207668 | Substituted pyridines/pyrimidines, their preparation, and their use as pesticides The present invention relates to novel substituted pyridines/pyrimidines of the formula I ##STR1## where A is CH or N; X is NH, oxygen or S(O)q where q is 0, 1 or 2; Y is a direct bond or CH2 ; Z is oxygen, NR7 or S(O) | 03/27/2001 |
| 6156889 | Reagent useful for cleaving a protected functional group The subject matter of the present invention relates to a reagent and a process useful for cleaving a functional group protected by an alkoxycarbonyl group during an organic synthesis. This reagent comprises: a) an aqueous phase; b) a catalyst comprising a... | 12/05/2000 |
| 6121255 | Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts ... | 09/19/2000 |
| 6100393 | Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and preferably over 2000 Dalt... | 08/08/2000 |
| 6005101 | Glutaryl 7-ACA derivatives and processes for obtaining them A compound having the following general formula (I): ##STR1## where R is a hydrogen atom; a linear or branched C1 -C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom; a benzyl gro... | 12/21/1999 |
| 5998611 | Process for producing cephem compounds in an aqueous medium An industrially excellent, novel process for producing cephem compounds which are useful as medicines, particularly, antibiotics and represented by the following formula (III): ##STR1## wherein R1 means either group represented by the foll... | 12/07/1999 |
| 5917032 | Chemical acetylation of desacetyl-cephalosporins The present invention is concerned with a chemical acetylation process for the preparation of 3'-acetylated cephalosporin from desacetyl-cephalosporin. The novel process is carried out with an acetyl donor and an activator or catalyst.... | 06/29/1999 |
| 5908929 | Process for the manufacture of the antibiotic 7-(D--amino--phenylacetamido)-3-methyl-3-cephem-4-carboxyl ic acid (cephalexin) and pharmaceutically acceptable salts thereof A process for the manufacture of the antibiotic 7-(D--amino--phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid (cephalexin) and pharmaceutically acceptable salts thereof. It consists of reacting an enamine protected potassium salt of ... | 06/01/1999 |
| 5874571 | Process for the recovery of cephalexin The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin be... | 02/23/1999 |
| 5869648 | Process for the purification of a 3-cephem-4-carboxylic acid derivative The invention relates to a new process for the depletion of 7-amino-3-(E)-1-propen-1-yl!-3-cephem-4-carboxylic acid in mixtures of 7-amino-3-(Z)-1-propen-1-yl!-3-cephem-4-carboxylic acid and 7-amino-3-(E)-1-propen-1-yl!-3-cephem-4 carboxylic acid, b... | 02/09/1999 |
| 5847116 | Process for the preparation of intermediates useful in the synthesis of cephalosporins A process is described for preparing 3-exomethylene cephalosporanic acid derivatives for use in the synthesis of cephalosporin antibiotics such as ceftibuten. The process comprises electrochemical reduction of a compound of the formula (IV) ##STR1## ... | 12/08/1998 |
| 5847117 | Reagent and catalytic process useful for cleaving a protected functional group The subject matter of the present invention relates to a reagent and a process useful for cleaving a functional group protected by an alkoxycarbonyl group during an organic synthesis. This reagent comprises: a) an aqueous phase; b) a catalyst comprising a... | 12/08/1998 |
| 5801241 | Cyclohexanone extraction of 3-hydroxymethylcephalosporins The cephalosporin intermediates, desacetyl 7-glutaryl ACA and desacetyl cephalosporin D, are obtained in the form of a concentrated aqueous solution from an aqueous solution containing said intermediates in less concentrated form by solvent extraction usi... | 09/01/1998 |
| 5760027 | Use of 7-alkylidene cephalosporins to inhibit elastase activity The present invention relates to the use of 7-alkylidene derivatives of cephalosporin esters, such as sulfides, sulfoxides, and sulfones, as inhibitors of human leukocyte elastase. These materials are therefore useful as anti-inflammatory and anti-degener... | 06/02/1998 |
| 5750682 | Glutaryl 7-ACA derivatives and processes for obtaining them There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom: a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom: a benzyl group substituted by at least a linear o... | 05/12/1998 |
| 5656755 | Process for preparation on 3-substituted cephem compound An object of the invention is to provide a process for preparing a 3-substituted cephem compound from an allenyl-ଲ-lactam compound which can be easily produced from an inexpensive penicillin compound by a simple reaction procedure. The process of th... | 08/12/1997 |
| 5637694 | Preparation and use of 7-[(2-carboalkoxy-1-methylethenyl)amino]-3-hydroxymethyl-3-cephem-4-carb oxylic acids This invention relates to a method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids from 3-hydroxymethyl-3-cephem-4-carboxylic acids in an aqueous medium for a practical, large-scale production. Moreover, the invention provides an ideal i... | 06/10/1997 |
| 5631366 | Process for making 3-formylcephem derivatives The present invention is concerned with a novel process for the making of a compound of formula I ##STR1## by oxidizing the corresponding 3-hydroxymethyl-cephem derivative with an inorganic hypohalite or inorganic halite in the presence of compounds ... | 05/20/1997 |
| 5629306 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 05/13/1997 |
| 5608055 | Beta lactam production A new process is described for the production of 7-alpha-aminoacyl-cephalosporin free from halogen-containing solvents by acylating 7-amino-ceph-3-em-4-carboxylic acid or a derivative thereof in a halogen-free solvent.... | 03/04/1997 |
