Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7208580 | Atomic structure of the hemalbumin complex and its use in designing therapeutic compounds A high resolution structure of the hemalbumin binding complex is provided which includes the detailed atomic coordinates which reflect the binding site and the binding characteristics of the structure. This high resolution structure can be used in methods of determi... | 04/24/2007 |
| 6921824 | Ruthenium dimeric complexes suitable as antimetastatic and antineoplastic agents New ruthenium dimeric complexes with high antimetastatic and antitumour activity and remarkable chemical stability are described. ... | 07/26/2005 |
| 6642376 | Rational synthesis of heteroleptic lanthanide sandwich coordination complexes A half-sandwich coordination complex, useful for the synthesis of triple-decker sandwich coordination compounds, is produced by reacting a precursor complex of the formula XM(R1)2 wherein X is a halogen, M is a metal, and R1 | 11/04/2003 |
| 6489342 | Aryloxy piperidinyl indoles for treating depression This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having the formula: ##STR1## wherein... | 12/03/2002 |
| 6165741 | Method for rapid detection of bacterial growth in cultures This invention provides a method for growth detection and identification of microorganisms in a culture medium comprising providing a culture medium comprising a solubilized oxygen-quenchable phosphorescent compound, inoculating said culture medium with a... | 12/26/2000 |
| 5801242 | Process for making quinolonyl lactam antimicrobials and novel intermediate compounds The present invention provides processes for making compounds of the structure (Q--L1)--L--(L2 --B) wherein (I) Q is a quinolone moiety; (II) B is a lactam moiety; and (III) L, L1, and L2 together comprise a linking moiet... | 09/01/1998 |
| 5633243 | Anti-tumor platinum complexes, their preparation and their therapeutic use Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R1, R2 and R7 are various organic groups, n is 0,... | 05/27/1997 |
| 5527905 | Anti-tumor platinum complexes, their preparation and their therapeutic use Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R1, R2 and R7 are various organic groups, n is 0,... | 06/18/1996 |
| 5281703 | Process for making antimicrobial quinolonyl lactams The present invention provides methods of making compounds of the structure [Q-L1 ]-L-[L2 -B[ wherein (I) Q is a quinolone moiety; (II) B is a beta-lactam moiety; (III) L, L1, and L2 together comprise a carbamate-containing ... | 01/25/1994 |
| 5252698 | Metal ion porphyrin-containing poly(azine) The present invention relates to porphyrin and metal ion-containing monomers and polymers. The monomers ##STR1## wherein R1, R2, R3, and R4 are independently selected from H, alkyl having 1 to 6 carbon atom... | 10/12/1993 |
| 5241070 | Nucleophilic polysubstituted aryl acridinium esters and uses thereof This invention is directed to novel nucleophilic polysubstituted aryl acridinium esters and to novel conjugates thereof. The novel nucleophilic polysubstituted aryl acridinium esters and novel conjugates thereof are useful in biological assays, including ... | 08/31/1993 |
| 5185330 | Penam derivatives and salts thereof, and antibacterial agent comprising the same A penam derivative represented by the following general formula or a salt thereof: ##STR1## wherein R1 represents a hydrogen atom, an amino-protecting group or an acyl group; R2 represents a hydrogen atom or a lower alkyl group;... | 02/09/1993 |
| 5099015 | Trifluoromethyl 1-carba(1-dethia)cephems 7-ଲ-Acylamino-1-carba-(1-dethia)-3-trifluoromethyl-3-cephem-4-carboxyl ic acids and derivatives are provided as antibiotics. Pharmaceutical formulations comprising the antibiotics, intermediates, and a process for their preparation are also provided.... | 03/24/1992 |
| 5057511 | 3-heterocyclic thiomethyl cephalosporins Cephalosporin compounds having a 3-position substituent of the formula (I) are described: --CH2 --S--Q--(y)n --P wherein Q is a 5- or 6-membered heterocyclic ring, P is a benzene ring substituted by groups R1 and R2 ... | 10/15/1991 |
| 4877782 | Zinc ceftiofur complexes Zinc ceftiofur complexes, e.g., zinc ceftiofur hydrochloride and zinc ceftiofur sodium complexes, have been found to provide the good antibiotic activity of ceftiofur while providing low dissolution rate and long half-life properties enabling the formulat... | 10/31/1989 |
| 4771134 | Ring-opening process for preparing azetidinone intermediates Compounds of formula I ##STR1## wherein R1 and R2 is each H, halo or an organic group, R3 is H or organic group, n=1 or 2, M is a heavy mono- or divalent metal, or M2 A wherein M2 is a heavy diva... | 09/13/1988 |
| 4719174 | Direct positive silver halide photographic light-sensitive material depress formation of re-reversed negative image A direct positive silver halide photographic light-sensitive material is described containing a weak electron donative, adsorptive compound represented by formula (I) or (II) effective for depressing formation of a re-reversed negative image, which is not... | 01/12/1988 |
| 4617300 | 2(N-heterocyclyl) penems There are disclosed 2(N-heterocyclyl) penems and their pharmaceutically acceptable salts and esters and their use as anti-bacterials.... | 10/14/1986 |
| 4614738 | 2-(N-heterocycloaliphaticthio)penems This invention relates to 2-(N-heterocycloaliphaticthio)penems wherein the nitrogen of the heterocyclic ring is connected to the alkyl group, and to their use as antibacterial agents.... | 09/30/1986 |
| 4610823 | Process for preparing substituted 2-thioxopenams and 2-substituted thiopenems Disclosed is a synthesis for preparing substituted 2-thioxopenams which are useful in the synthesis of penem antibiotics 7 which may be conducted in an enantiospecific manner; said process proceeds from azetidinone 1 via the azetidinone acetic ester 2, th... | 09/09/1986 |
| 4574152 | Cephalosporin compounds Ternary complexes comprising a 7-[D-5-amino-5-carboxypentanamido] cephalosporin complexed with copper (II) ions and an organic nitrogen base as well as a process for their preparation are described. The complexes may be used in the isolation and/or purifi... | 03/04/1986 |
| 4540579 | 2-[(R) Amino acid alkyl]penems Disclosed are 6-(1'-hydroxyethyl)-2-[(R)-amino acid alkyl]penem-3-carboxylic acids and salts thereof having an absolute stereochemisty of 5R,6S,8R. The compounds are useful and potent antibacterial agents and can be formulated into a variety of forms ... | 09/10/1985 |
| 4530793 | Processes for the production of penems Processes for the production of 6-hydroxyethyl-2-substituted thio penem-3-carboxylates are disclosed as well as novel penems.... | 07/23/1985 |
| 4497738 | Analogous compounds of cephalosporins, processes for the preparation thereof and pharmaceutical composition comprising the same The invention relates to novel compounds of high antimicrobial activity, and to novel intermediates for the preparation of said compounds, said intermediates being of the formula: ##STR1## in which W is a protective amino group and Y is --S--Ag or --... | 02/05/1985 |
| 4378314 | Antibacterial agents and metal containing azetidinone intermediates therefore This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are p... | 03/29/1983 |
| 4369312 | Method of producing oxo-containing azetidinone compounds This invention relates to a novel method of producing oxo-containing azetidinone compounds, or salts thereof, or hydrates thereof, said compounds having utility as antimicrobial agents and as intermediates for the synthesis of other azetidinone compounds ... | 01/18/1983 |
| 4323567 | Arylmalonamido-1-oxadethiacephalosporins Antibacterial 1-oxadethiacephalosporins of the formula: ##STR1## wherein Ar is ##STR2## (in which Acyl is organic or inorganic acyl); COB1 and COB2 each is carboxy or protected carboxy; Het is ##STR3## (in which... | 04/06/1982 |
| 4293462 | Process for the manufacture of enol derivatives, and intermediates The invention concerns a process for the manufacture of 7ଲ-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolyzing t... | 10/06/1981 |
| 4283333 | -[4-Oxoazetidin-1-yl]-acetic acid compounds useful as intermediates in preparing 1-oxadethiacephalosporins Azetidine derivatives of the formula: ##STR1## wherein A is amino or substituted amino; COB is carboxy or protected carboxy; R1 is .dbd.C(CH3)2, ##STR2## (R4 is alkyl, aryl or aralkyl); OR2 ... | 08/11/1981 |
| 4272437 | Antibacterial agents, and 4-thio azetidinone intermediates This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula ##STR1## wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are p... | 06/09/1981 |
| 4233216 | Azetidinone derivatives and production thereof -[3(R)-Substituted amino-4(R)-substituted alkoxy-2-oxo-azetidin-1-yl]--isopropenylacetate (Ia) and -[3(R)-substituted amino-4(R)-substituted alkoxy-2-oxo-azetidin-1-yl]--isopropylideneacetate (Ib) prepared from (1R,5S... | 11/11/1980 |
| 4230622 | Halogen derivatives of clavulaic acid Novel halogen derivatives of clavulanic acid are described which are of value in the preparation of a range of clavulins which either inhibit ଲ-lactamases or show activity against strains of both gram-positive and gram-negative bacteria. Processes f... | 10/28/1980 |
| 4204058 | Process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions A novel process for obtaining cephalosporin C and the salts and derivatives thereof from culture filtrates or culture solutions is provided which comprises drying the culture filtrate or culture solution, dissolving it in an optionally water-containing so... | 05/20/1980 |
| 4183855 | Oxazolinoazetidinylbutyric acid derivatives Intermediates (I) for preparing a potent antibacterial, 1-oxadethiacephalosporin, are shown by the following formula ##STR1## (wherein R is a group of acyl-minus-carbonyl derived from a carboxylic or carbonic acid; COB is carboxy or protected carboxy... | 01/15/1980 |
| 4175076 | Azetidinone mercury sulfides and process therefor Novel azetidinone mercury sulfides are prepared by the reaction of penicillin derived thiazolineazetidinones with a mercuric halide in the presence of an alcohol or glycol. They are useful intermediates in the preparation of cephalosporin compounds.... | 11/20/1979 |
| 4169947 | 7ଲ-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins 7ଲ-[[[2-Acylamino]-1,2-dioxoethyl]amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R1 is h... | 10/02/1979 |
| 4130557 | Method for the hydrolysis of azetidinothiazoline compounds A process for preparing compounds having the formula: ##STR1## WHEREIN R is phenoxymethyl or benzyl; R2 is 1-methoxyethylidene, 1-hydroxyethylidene, or 1,1-dimethoxyethylidene; and R3 is trichloroethyl, diphenylmethyl, p-nitrobenzyl,... | 12/19/1978 |
| 4128724 | Hydrazinocarbonylamino cephalosporins New -hydrazinocarbonylamino cephalosporins which have the formula ##STR1## are useful as antimicrobial agents.... | 12/05/1978 |
| 4127716 | 3-HETEROTHIOMETHYL UREIDO CEPHALOSPORINS L-Isomer compounds of the formula ##STR1## wherein R1 is phenyl, thienyl or furyl; R4 represents certain heterocyclic groups; R3 is hydrogen, lower alkyl, phenyl-lower alkyl, substituted phenyl-lower alkyl, diphenyl-l... | 11/28/1978 |
| 4113943 | 7ଲ-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins 7ଲ-[(2-Amino-1,2-dioxoethyl)amino]acyl cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl or a salt forming ion; R1 is hydrogen, lo... | 09/12/1978 |
