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Behavior Modification Wristwatch
A wristwatch including a watch band and a watch body having an octagon shaped perimeter and being red in color and having the word STOP thereon to resemble a stop sign.
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| Number | Title | Issue Date |
| 8124744 | Macrolide derivatives Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for ... | 02/28/2012 |
| 7807800 | Erythromycins and process for their preparation 14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may b... | 10/05/2010 |
| 7741456 | Polyketides and antibiotics produced by combinatorial techniques Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compoun... | 06/22/2010 |
| 7645864 | Erythromycin derivative having novel crystal structures and processes for their production The present invention provides an E-type crystal of N-demethyl-N-isopropyl-12-methoxy-11-oxo-8,9-anhydroerythromycin A-6,9-hemiacetal fumarate having strong diffraction peaks at diffraction angles (2θ) of 5.6° and 10.4° as measured by powder X-ray diffractometry,... | 01/12/2010 |
| 7435805 | O-alkyl macrolide and azalide derivatives and regioselective process for their preparation The present disclosure relates to new 11-O-alkyl macrolides and azalides and pharmaceutically acceptable salts and solvates thereof, and to pharmaceutical compositions thereof. The disclosure also relates to a process for the preparation of 11-O-alkyl macrolides and... | 10/14/2008 |
| 7419962 | 3,6-bicyclolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical com... | 09/02/2008 |
| 7414030 | 6-11 Bicyclic erythromycin derivatives The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates... | 08/19/2008 |
| 7407941 | N-desmethyl-N-substituted-11-deoxyerythromycin compounds Compounds having the structure of formula I wherein R1, R2, R3, R4, R5, and R6 are as defined herein, are prokinetic agents and can be used to treat disorder... | 08/05/2008 |
| 7407942 | 3,6-bridged 9,12-oxolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical com... | 08/05/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7297682 | Diphosphate salt of a 4″—substituted-9-deoxo-9 A—AZA—homoerythromycin derivatives and its pharmaceutical composition This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-O-methyl-4-C-[(propylamino)methyl]-α-L-ribo-hexopryanosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideo... | 11/20/2007 |
| 7291602 | 11,12-lactone bicyclolides The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmace... | 11/06/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7273853 | 6-11 bicyclic ketolide derivatives The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmace... | 09/25/2007 |
| RE39836 | Macrolide antinfective agents Compounds of the formula wherein Ra is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C); substituted or unsubstituted alkynyl (2-10C); subst... | 09/11/2007 |
| 7265249 | Enantioselective alpha-fluorination of aldehydes using chiral organic catalysts Nonmetallic, chiral organic catalysts are used to catalyze enantioselective fluorination of enolizable aldehydes. Reaction systems composed of an enolizable aldehyde, an electrophilic fluorination reagent, and a nonmetallic chiral catalyst in the form of an imidazol... | 09/04/2007 |
| 7259170 | Macrolides containing pharmaceutical compositions A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s). ... | 08/21/2007 |
| 7229972 | 3,6-Bicyclolides The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmac... | 06/12/2007 |
| 7211568 | 9-Desoxoerythromycin compounds as prokinetic agents 9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of g... | 05/01/2007 |
| RE39591 | 6-O-substituted ketolides having antibacterial activity Antimicrobial compounds having the formula as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administr... | 04/24/2007 |
| 7202221 | Macrolides The present invention relates to 14 or 15 membered macrolides substituted at the 4′ position of formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topica... | 04/10/2007 |
| 7198922 | Polyketides and their synthesis A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further k... | 04/03/2007 |
| RE39531 | 9-hydrazone and 9-azine erythromycin derivatives and a process for making the same Disclosed are 9-hydrazone erythromycin and 9-azine erythromycin derivatives and the processes for making the same. The compounds are useful intermediates for conversion into 6-O-alkyl erythromycin. Also disclosed are the processes for converting the compounds into 6... | 03/27/2007 |
| 7163924 | Ketolide derivatives Antimicrobial ketolide compounds are provided having the formula (A): as well as pharmaceutically acceptable salts, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds, methods of tr... | 01/16/2007 |
| RE39383 | Process for 6-O-alkylation of erythromycin derivatives A procedure for preparing 6-O-alkyl erythromycin compounds having the formula: wherein R1 is a loweralkyl group, R2 and R3 an independently hydrogen or a hydroxy-protecting group, except that R | 11/07/2006 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7109176 | Nonsteroidal anti-inflammatory substances, compositions and methods for their use The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory ce... | 09/19/2006 |
| 7101858 | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same The present invention relates to processes for preparing protected silylated clarithromycin oxime, preferably 6-O-methyl-2′,4″-bis(trimethylsilyl)-erythromycin A 9-O-(2-methoxyprop-2-yl)oxime (“S-MOP oxime”), and for converting protected silylated clarithrom... | 09/05/2006 |
| 7091196 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,... | 08/15/2006 |
| 7071314 | Arylation method for the functionalization of O-allyl erythromycin derivatives An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl... | 07/04/2006 |
| 7071170 | Macrolide antibiotics This invention relates to compounds of the formula wherein a, R1, R2, R3, R4, R5, R6 and X are each as defined above, and to pharmaceutically acce... | 07/04/2006 |
| RE39149 | Method of administering azithromycin An oral dosage form of azithromycin which does not exhibit an adverse food effect; Specific azithromycin oral dosage forms including tablets, powders for oral suspensions and unit dose packets; Methods of treating microbial infections with the dosage forms; And ther... | 06/27/2006 |
| 7049100 | Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of no... | 05/23/2006 |
| 7049417 | 6,11-4-Carbon bridged ketolides Novel 6,11-4-carbon bridged ketolides, pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically-acceptable carrier are described. Also described are a method for trea... | 05/23/2006 |
| 7034005 | Use of agent for suppressing infection and proliferation of human immunodeficiency syndrome virus The present invention relates to agent for suppressing infection and proliferation of human immunodeficiency syndrome virus (HIV-1), which infects immunocompetent cells such as macrophage or dendritic cell and causes destruction of immune system, and use of known co... | 04/25/2006 |
| 7022825 | Polyketides and antibiotics Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting pol... | 04/04/2006 |
| 7015203 | Macrolides The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention are antibacterial agents that may be used to treat various bacterial a... | 03/21/2006 |
| 6998390 | Oxolide antibacterials Antibacterial compounds having formula (I) and formula (II) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employe... | 02/14/2006 |
| 6995143 | Macrolides with antibacterial activity The invention provides new macrolides antibiotics of formula I with improved biological properties and having the formula wherein R1, R2 and R3 are as herein described. ... | 02/07/2006 |
| 6987175 | Processes for preparing clarithromycin polymorphs The present invention relates to processes for converting clarithromycin Form I to clarithromycin Form II, which include slurrying clarithromycin the Form I in water. The present invention also relates to processes for the preparation of clarithromycin Form II by co... | 01/17/2006 |
