Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7476727 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 01/13/2009 |
| 7138427 | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed ... | 11/21/2006 |
| 7138517 | Sugar modified oligonucleotides Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specificall... | 11/21/2006 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 6979547 | Methods for designing specific ion channel blockers The present invention relates to a method of designing an ion channel blocker for an ion channel which includes providing an ion channel having an external vestibule portion and raising an antibody, binding portion, probe, or ligand specific to the external vestibul... | 12/27/2005 |
| 6916791 | Androgen derivatives and uses thereof Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver. ... | 07/12/2005 |
| 6911325 | Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic hydrolysis A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger. ... | 06/28/2005 |
| 6897298 | Method for extracting a compound from a ginseng spp. plant, ginseng or pseudo-ginseng This invention discloses a compound (I) of the following formula. This invention also includes a method for extracting the compound (I), and a pharmaceutical composition containing the compound (I). The extracting method includes the following steps: taking the corp... | 05/24/2005 |
| 6686515 | Homologous recombination in plants Methods for evolving recombinase protein homologues and RecA/VirE2 fusion proteins which complement VirE2 deficient Agrobacterium are provided. The use of recombinase protein homologues and RecA/VirE2 fusion proteins in the context of Agrobacterium mediat... | 02/03/2004 |
| 6670459 | Process for the isolation of novel oligospirostanoside The present invention relates to a process for the isolation of a novel oligospirostanoside structurally constructed as 3-0-[-L-rhamnopyranosyl-(1.fwdarw.2)--L-rhamnopyranosyl-(1.f wdarw.4)-0-ଲ-D-glucopyranosyl]-25(S)-5ଲ spirostan... | 12/30/2003 |
| 6630453 | Androgen derivatives and uses thereof Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver.... | 10/07/2003 |
| 6417380 | Synthesis of 1,2-dioxetanes and intermediates therefor Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a compound ... | 07/09/2002 |
| 6407069 | Method for purifying GBS toxin/CM101 A method for purifying a polysaccharide from group B ଲ-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline ... | 06/18/2002 |
| 6159931 | Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells The present invention provides a lipid-modified insulin comprising an insulin molecule linked to an alkyl group by an amine linkage. Preferably, the alkyl group is a straight chain carbon comprising from about 14 to 20 carbon atoms. Preferably, the alkyl ... | 12/12/2000 |
| 6136789 | Polysaccharide toxin from group B -62 hemolytic streptococcus (GBS) having improved purity A method for purifying a polysaccharide from group B ଲ-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline ... | 10/24/2000 |
| 6121430 | Regiospecific synthesis of glucose-based surfactants New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active ... | 09/19/2000 |
| 6075139 | Linear and cyclic sucrose reaction products, their preparation and their use Sucrose ester and ether products, useful as food or beverage bulking agents, reduced calorie sweeteners, fat replacement agents, stabilizing agents, thickening agents and emulsifying agents; adhesives; biodegradable plastics and films; sizing agents for p... | 06/13/2000 |
| 5939396 | Method for purifying GBS toxin/CM101 A method for purifying a polysaccharide from group B ଲ-hemolytic Streptococcus (GBS) bacteria includes contacting a bacterial fermentation stock with a hydrophobic interaction chromatography (HIC) resin. Additional steps may include a phenol/saline ... | 08/17/1999 |
| 5919770 | Metabolites of ginseng saponins by human intestinal bacteria and its preparation for an anticancer This invention relates to ginsenoside Mc with formula (I), ##STR1## an intestinal flora metabolite of ginseng saponin and anticancer agent containing it as an active ingredient. In addition to a novel compound, the anticancer agent of this invention ... | 07/06/1999 |
| 5861382 | Methods for regulation of active TNF- Substances comprising disaccharides and substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secre... | 01/19/1999 |
| 5811403 | Polysaccharide toxin from Group B ଲ-hemolytic Streptococcus (GBS) having improved purity The invention relates to a polysaccharide toxin from group B ଲ-hemolytic Streptococcus (GBS) having improved purity. The improved purity of the toxin, 95%, is achieved by the method of purification wherein a bacterial fermentation stock is subjected... | 09/22/1998 |
| 5760009 | Spirostanyl glycosidal crystalline monohydrate A crystalline monohydrate of (3ଲ,5,25R)-3-(ଲ-D-cellobiosyl)oxy!spirostan-11-one that is useful as a hypocholesterolemic or antiatherosclerosis agent.... | 06/02/1998 |
| 5750729 | Compounds and methods for making and using same In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame re... | 05/12/1998 |
| 5698526 | Steroidal glycosides This invention relates to certain steroidal glycosides of Formula I ##STR1## wherein the values for the variables are described herein, which are useful as hypocholesterolemic agents and antiatherosclerosis agents and certain protected intermediates ... | 12/16/1997 |
| 5695738 | Steroidal C-glycosides Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/o... | 12/09/1997 |
| 5610151 | Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS I, in which GS, X and Z have the meanings give... | 03/11/1997 |
| 5606041 | Process for steroidal peracyl glycosides Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting -cellobiosyl bromide heptaalkanoate and ³... | 02/25/1997 |
| 5583112 | Saponin-antigen conjugates and the use thereof Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.... | 12/10/1996 |
| 5563250 | Cleavable conjugates for the delivery and release of agents in native form The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded directly to the linker, cleavage can result in release of ... | 10/08/1996 |
| 5525480 | N- and O-substituted aminophenols, method and use for diagnosis The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates fo... | 06/11/1996 |
| 5514369 | Mild shampoo composition Foaming shampoo compositions which contain no anionic surfactant and are mild to the skin and eyes are comprised of alkyl polyglycosides, betaines, and polymeric slip agents.... | 05/07/1996 |
| 5502038 | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption Glycosides having neotigogenin aglycone moieties, administered orally to mammals are shown to inhibit the absorption of cholesterol. These compounds are useful in the treatment of hypercholesterolemia. Particular compounds are derived from tomato seeds an... | 03/26/1996 |
| 5494659 | Hair treatment composition Hair treatment compositions containing (a) an alkyl polyglycoside of the formula I R1 O--[G]p (I) wherein R1 is an alkyl or alkenyl radical having from 6 to 22 carbon atoms, G is a sugar un... | 02/27/1996 |
| 5424304 | 17-aryl-substituted steroidal compounds active on the cardiovascular system Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R1, R2, R3, R4, R5, R6 and R7 have the meanings shown in the description, and pharmaceutical compositio... | 06/13/1995 |
| 5294703 | Process for preparing -D-cellobiose octaacetate Provided is a novel improved process for the preparation of -D-cellobiose octaacetate via the acetylative degradation of cellulose or cellulose acetate. The title compound is provided in high yield and quality in a facile one-pot process, amenable ... | 03/15/1994 |
| 5246695 | Use of alkylglycoside sulfosuccinates for the production of cosmetic preparations and cleaning agents The invention relates to alkylglycoside sulfosuccinates of the general formula (1) defined herein, useful in cosmetic preparations.... | 09/21/1993 |
| 5198427 | Natural intense sweeteners The present invention relates to novel sweet compounds derived from the leaves of the subtropical weed Abrus precatorius, and their use as sweeteners. In particular, the present invention contemplates four novel sweet compounds isolated from A. precatoriu... | 03/30/1993 |
| 5162513 | L-isomeric sugars having formed stereogenic centers of R configuration: methods and compositions The present invention provides L-isomeric nine-carbon sugars having a formed stereogenic center of R configuration, as well as methods of synthesizing the same.... | 11/10/1992 |
| 5139034 | Smoking compositions containing a menthol-release additive In one embodiment, this invention provides a smoking composition which contains a flavorant additive which releases menthol under normal cigarette smoking conditions. The menthol-release additive is a mixture of menthyloxycarbonylglucose compounds which i... | 08/18/1992 |
| 5109126 | 5'[2'(3')-O-(2,4,6-trinitrophenyl) pyprimidine nucleoside]diphosphate 1-glycosides A method of assaying, detecting, monitoring, and influencing in vitro and in vivo activity of glycosyltransferase and sugar nucleotides which are analogs of the naturally-occurring sugar nucleotides for which the glycosyltransferases are specific. These s... | 04/28/1992 |
