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| Number | Title | Issue Date |
| 4952567 | Inhibition of lipogenesis A process which comprises administering an antagonist of protein kinase C and/or the insulin receptor tyrosine kinase to a mammal in an amount therapeutically effective to inhibit lipogenesis in the mammal.... | 08/28/1990 |
| 4950750 | Glycolipid containing N-glycolylneuraminic acid and method of producing the same The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R1 denotes a hydrogen atom or SiR3 R4 R5 (wherein R3 and R4 each deno... | 08/21/1990 |
| 4940694 | Therapeutic use of GM1 in severe cerebral ischemic strokes pathologies A pharmaceutical preparation containing the ganglio-side GM1 or an inner ester derivative thereof and a method for increasing cerebral blood flow in stroke victims by acute administration of GM1 or its inner ester derivative.... | 07/10/1990 |
| 4939083 | Carbohydrate specific to chronic myelogenous leukemia granulocytes A substantially purified carbohydrate is provided which is isolated from chronic myelogenous leukemia cells. The carbohydrate is immunogenic and can be utilized to raise both polyclonal and monoclonal antibodies.... | 07/03/1990 |
| 4937327 | Derivative of D.25, process for its preparation, its use as an immunostimulant, and pharmaceutical compositions containing the derivative The present invention relates to a polysaccharide derivative, which is a derivative of D.25 in which the galactofuranose (Galf) residues of the linear polysaccharide chain have been converted at least partly to arabinose. It also relates to the... | 06/26/1990 |
| 4918170 | Process for producing gangliosides The present invention provides a novel process for producing gangliosides such as GM3 and GM4 and analogues thereof. This process has the excellent characteristics in that in introduction of ceramide into sialooligosaccharides, first... | 04/17/1990 |
| 4910142 | Cell culture microcarrier, method for preparing same and use thereof for cultivating anchorage-dependent cells A cell culture microcarrier having positively charged cross-linked polysaccharides and basic groups linked therewith wherein the basic groups have the formula (I) ##STR1## with Z being an optionally substituted hydrocarbon chain having at least 2 ... | 03/20/1990 |
| 4886787 | Method of preventing adhesion between body tissues, means for preventing such adhesion, and process for producing said means The invention is concerned with a method of preventing adhesions or accretions of body tissues inter se by means of employing a degradable gel of a crosslinked carboxyl-containing polysaccharide. The invention also covers a gel product to be used for this... | 12/12/1989 |
| 4885244 | Method of producing hyaluronic acid High molecular weight hyaluronic acid can be efficiently produced by incorporating one or more compounds having at least one aromatic ring to which one or more hydroxyl groups are attached into a medium for producing hyaluronic acid by a bacterium capable... | 12/05/1989 |
| 4882317 | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membran... | 11/21/1989 |
| 4879375 | Preparation of hyaluronic acid from synovial fluid A method for preparing high purity hyaluronic acid comprising treating a proteinaceous solution containing hyaluronic acid to precipitate protein and said hyaluronic acid from the solution, denaturing the protein, adding the hyaluronic acid and denatured ... | 11/07/1989 |
| 4871839 | Skin treatment composition A composition suitable for topical application to human skin, particularly the scalp comprises a minoxidil glucuronide together with a cosmetically and/or physiologically acceptable vehicle. The composition is particularly suited to stimulating hair growt... | 10/03/1989 |
| 4870166 | Process for preparing high-purity dematan sulphate, and pharmaceutical compositions which contain it A process for preparing dermatan sulphate (DS) of pharmaceutical purity from animal organs rich in mucopolysaccharides (MPS), by: (a) stabilizing the fresh organs by freezing them either as such or in the form of powder, (b) micronizing the material conta... | 09/26/1989 |
| 4859349 | Polysaccharide/perfluoroalkyl complexes The instant invention relates to water-soluble anionic polysaccharides bound to perfluoroalkyl cationic surfactants. Polymer complexes are formed which are especially useful for fighting fires of hydrophilic or polar liquids. They have the unique property... | 08/22/1989 |
| 4851521 | Esters of hyaluronic acid The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterfied, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds posse... | 07/25/1989 |
| 4851395 | Nitrogen-containing polysaccharide Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus versicolor (Fr.) Quel., substantially all polymer units ha... | 07/25/1989 |
| 4851338 | Method for diagnosing the presence of bacteria A composition for therapeutic or diagnostic use in regard to pathogenic microorganisms, containing as an active constituent a structural element having the formula: ##STR1## wherein R1, R2, R3 and R4 are sa... | 07/25/1989 |
| 4849413 | Ganglioside derivatives New functional ganglioside derivatives comprising ester, amide and peracylated derivatives of gangliosides, preparation procedures therefor, pharmaceutical preparations containing the same, and the therapeutic use of the derivatives.... | 07/18/1989 |
| 4849505 | Detectable molecules, method of preparation and use A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, th... | 07/18/1989 |
| 4843122 | Detectable molecules, method of preparation and use A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis .OH, halides, aryl, imidazoyl, carbonyl, carboxy, t... | 06/27/1989 |
| 4837313 | Polygalactosamine PF-192 and salts thereof A natural polymer material PF-102 and salts thereof are widely available as a convenient flocculant for fine suspended matters. PF-102 can be produced by, for example, an imperfect fungus Paecilomyces I-1 (FERM BP-1180).... | 06/06/1989 |
| 4830852 | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins and methods of preparing such polysaccharides and conjugates Covalently-modified neutral bacterial polysaccharides; covalent conjugates of such polysaccharides linked by a bigeneric spacer, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and metho... | 05/16/1989 |
| 4831126 | Antigenic polysaccharide specific to Brucella abortus and Yersinia enterocolitica serotype 0:9 The antigenic O-chain polysaccharides from Brucella abortus and Yersinia enterocolitica serotype 0:9 have similar structure, i.e. 1-2 linked 4,6-dideoxy-4-formamido--D-mannopyranosyl units. The antigen is more readily isolated from the Yersinia and... | 05/16/1989 |
| 4831021 | Ganglioside derivatives A novel mono-sialo ganglioside derivative substantially identical chemically and physically with a product prepared by (a) concentration of an aqueous solution of a mono-sialo ganglioside and calcium ions under sub-atmospheric pressure at 40°-80° C. for... | 05/16/1989 |
| 4824946 | Cell culture microcarrier, method for preparing same and use thereof for cultivating anchorage-dependent cells A cell culture microcarrier having positively charged cross-inked polysaccharides and basic groups linked therewith wherein the basic groups have the formula (I) ##STR1## with Z being an optionally substituted hydrocarbon chain having at least 2 ... | 04/25/1989 |
| 4814437 | Method for preparation of sulfated polysaccharides by treating the polysaccharide with a reducing agent before sulfation A new method for preparation of sulfated polysaccharides by means of pyridine-chlorosulfonic acid reagents. The polysaccharide is before sulfation treated with a reducing agent, e.g. sodium borohydride.... | 03/21/1989 |
| 4810784 | Process for covalent coupling for the production of conjugates, and products hereby obtained A process to produce by covalent binding conjugates of a substance containing a 2-amino-2-deoxyglycopyranosyl residue the NH2 -function of which in its most stable conformation is equatorially oriented, and a substrate containing a primary amin... | 03/07/1989 |
| 4808576 | Remote administration of hyaluronic acid to mammals The present disclosure is concerned with the discovery that hyaluronic acid, an agent well known to reduce the sequelae of trauma in mammalian joint tissue when applied directly to the traumatized tissue, will be carried to such traumatized tissue by the ... | 02/28/1989 |
| 4801539 | Fermentation method for producing hyaluronic acid Streptolysin-free hyaluronic acid is produced by cultivating a microorganism belonging to a genus Steptococcus which is anhemolytic and is capable of producing hyaluronic acid (e.g., Streptococcus zooepidemicus FERM BP-784) in a culture medium.... | 01/31/1989 |
| 4801619 | Hyaluronic acid preparation to be used for treating inflammations of skeletal joints Hyaluronic acid preparation containing an effective amount of hyaluronic acid of a molecular weight exceeding 3×106 dalton, for intra-articular administration in the treatment of steroid arthropathy and progressive cartilage degeneration cause... | 01/31/1989 |
| 4784990 | High molecular weight sodium hyaluronate A novel mutant microorganism Streptococcus zooepidemicus HA-116 ATCC 39920, has been produced. The microorganism produces large amounts of high molecular weight hyaluronic acid. The invention provides a method of obtaining such microorganisms. The inventi... | 11/15/1988 |
| 4782046 | Ultrapure hyaluronic acid and method of making it Hyaluronic acid having controlled molecular weight and substantially free of protein and nucleic acids can be prepared from a hyaluronidase-negative or hyaluronidase inhibited microbiological source. Product may be used as replacement fluid in mammals.... | 11/01/1988 |
| 4772419 | Shaped article and processes for its preparation A shaped article based upon cross-linked, possibly derivatized hyaluronic acid or a salt thereof is characterized in that it has a dry matter content of at least 65 percent by weight and a tensile strength of at least 2 N/cm2. The shaped articl... | 09/20/1988 |
| 4764507 | Polysaccharide RDP substance A polysaccharide RDP substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the 13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction.... | 08/16/1988 |
| 4762825 | Polysaccharide RON substance A polysaccharide RON substance having the ultraviolet absorption spectrum depicted in FIG. 1, the infrared absorption spectrum depicted in FIG. 2 and the 13 C-NMR spectrum depicted in FIG. 3 is obtained from rice bran by extraction and purifica... | 08/09/1988 |
| 4761401 | Oligosaccharides Esterified oligosaccharides particularly estersified disaccharides containing a uronic acid residue and a hexosamine residue joined through a glycosidic linkage. Such as useful in cosmetic and pharmaceutical compositions.... | 08/02/1988 |
| 4740589 | Capsular polysaccharide metal complex vaccines Complexes comprising a metal constituent and a bacterial capsular polysaccharide constituent, wherein the polysaccharide contains sialic acid, are useful in the prophylaxis and treatment of bacterial diseases. The polysaccharide is preferably colominic ac... | 04/26/1988 |
| 4734403 | Membrane polysaccharides which are useful as immunostimulants The present invention relates to a membrane polysaccharide of bacterial origin having the following quantitative analytical composition:... | 03/29/1988 |
| 4728641 | Ganglioside derivatives A novel mono-sialo ganglioside derivative substantially identical chemically and physically with a product prepared by (a) concentration of an aqueous solution of a mono-sialo ganglioside and calcium ions under sub-atmospheric pressure at 40°-80° C. for... | 03/01/1988 |
| 4727136 | Modified meningococcal group B polysaccharide for conjugate vaccine The group B polysaccharide of Neisseria meningitidis is chemically modified to enhance the immune response thereto, thereby providing cross-reactive antibodies of high affinity. The N-acetyl group of the sialic acid residues of the polysaccharide has been... | 02/23/1988 |
