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| Number | Title | Issue Date |
| 7985848 | Pharmaceutical composition for preventing and treating diabetes or glucose control abnormality comprising ginsenosides The present invention relates to a composition for preventing or treating diabetes or blood glucose control abnormality comprising gisenosides Rg3, Rg5, and Rk1 from natural substances; a use of a mixture comprising gisenosides Rg3, Rg5, and Rk1 for the manufacture ... | 07/26/2011 |
| 7884195 | Method of extracting ginsengnoside Rgm, pharmaceutical composition including ginsengnoside Rg, and uses thereof The present invention provides a method of extracting ginsenoside Rg2, which is applied to mass production. The method of the present invention employs gradient salting-out instead of conventional silica gel chromatography, and therefore enables convenien... | 02/08/2011 |
| 7435816 | Synthesis of solanum glycosides The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R1 is a benzylidene, 4-nitrobenzylidene or 4-me... | 10/14/2008 |
| 7416744 | Extracts, compounds and pharmaceutical compositions having anti-diabetic activity and their use The invention relates inter alia to pharmaceutical compositions containing an extract obtainable from a plant of the genus Trichocaulon or Hoodia having anti-diabetic activity; and to the use of such extracts and to compound (1) as herein defined and i... | 08/26/2008 |
| 7390782 | Methods and products related to metabolic interactions in disease The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.... | 06/24/2008 |
| 7361644 | Specific antagonist for both E- and P-selectins Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 04/22/2008 |
| 7355056 | Transfection agents The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents... | 04/08/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7265101 | Appetite-suppressing compositions and methods The invention relates to appetite-suppressing compositions obtained from botanical sources. More specifically, the invention relates to appetite-suppressing compositions comprising an extract product of an Asclepias plant, methods of making an appetite-suppre... | 09/04/2007 |
| 7211663 | Synthesis of oligosaccharides, reagents and methods related thereto One aspect of the present invention relates to differentially protected glycosyl phosphates. Another aspect of the present invention relates to the preparation of glycosyl phosphates from glycal precursors. In another aspect of the present invention, glycosyl phosph... | 05/01/2007 |
| 7208483 | Polymeric delivery agents and delivery agent compounds Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 04/24/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7189874 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S... | 03/13/2007 |
| 7173154 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 02/06/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7166745 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/23/2007 |
| 7166611 | Pharmaceutical compositions having appetite suppressant activity A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1... | 01/23/2007 |
| 7160866 | Isolation of tigogenin pentaglycoside from The present invention provides a novel saponin tigogenin penta glycoside isolated from the aerial parts of Chlorophytum nimonii and a process for the isolation thereof as well as its use in anti-hyperglycemic and hypolipidemic activities. ... | 01/09/2007 |
| 7144994 | Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms A new isoform of manganese superoxide dismutase (MnSOD) and polynucleotides encoding it have been identified. This isoform, MnSOD E3(−), is a splice variant lacking exon 3 of the full length MnSOD. The polypeptide can be expressed using appropriate host cells. Mod... | 12/05/2006 |
| 7145039 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 12/05/2006 |
| 7091187 | Compounds, compositions and methods for treatment of inflammatory diseases and conditions The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory ce... | 08/15/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7084121 | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. M... | 08/01/2006 |
| 7060685 | Compounds and methods for inhibiting selectin-mediated function Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 06/13/2006 |
| 7037907 | Estradiol conjugates and uses thereof A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent. ... | 05/02/2006 |
| 7033616 | Extracts, compounds and pharmaceutical compositions having anti-diabetic activity and their use The invention relates inter alia to pharmaceutical compositions containing an extract obtainable from a plant of the genus Trichocaulon or Hoodia having anti-diabetic activity; and to the use of such extracts and to compound (1) as herein defined and i... | 04/25/2006 |
| 7030084 | Drug-oligomer conjugates with polyethylene glycol components The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 04/18/2006 |
| 6992068 | Cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents, immunosuppressants, drugs, cosmetics, foods and food materials Highly safe cytokine production inhibitors, agents for protecting and promoting liver function, anti-inflammatory agents and immunosuppressants. Brazilian licorice extract and periandrins, which are constituents thereof, have excellent characteristics of showing eff... | 01/31/2006 |
| 6984725 | Method for the separation of triglycoalkaloids In accordance with the present invention there is provided a method for the separation of a triglycoalkaloid in which the triglycoside portion comprises α-L-rhamnopyranosyl-(1→2gal)-O-β-D-glucopyranosyl-(1→3gal)-β-D-galactopyranose (or 6-deoxy-α-L-mannopyran... | 01/10/2006 |
| 6966992 | Method of purification of molecules using unbranched terminal alkyldiols The current invention provides methods for molecule purification by RP-LC and RP-HPLC that uses unbranched terminal alkyldiols as eluting solvents. In particular, the present invention purifies molecules, particularly proteins and peptides, on reverse phase liquid c... | 11/22/2005 |
| 6956051 | Enkephalin conjugates The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to ... | 10/18/2005 |
| 6949523 | Aglycon dammarane sapogenins, their use as anti-cancer agents, and a process for producing same This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sap... | 09/27/2005 |
| 6943148 | Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugates comprise a therapeutic compound conjugated to ... | 09/13/2005 |
| 6930090 | Methods of activating a receptor using amphiphilic drug-oligomer conjugates The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic drug-oligomer conjugate comprises a therapeutic compound conjugated to ... | 08/16/2005 |
| 6916791 | Androgen derivatives and uses thereof Androgen glycosides provide free, circulatory androgen on oral administration as they are subject to less, first pass breakdown by the liver. ... | 07/12/2005 |
| 6897298 | Method for extracting a compound from a ginseng spp. plant, ginseng or pseudo-ginseng This invention discloses a compound (I) of the following formula. This invention also includes a method for extracting the compound (I), and a pharmaceutical composition containing the compound (I). The extracting method includes the following steps: taking the corp... | 05/24/2005 |
| 6888014 | Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sap... | 05/03/2005 |
| 6884885 | Production of cyclodextrin complexes The process entails increasing the concentration of cyclodextrin to 15% (w/w) and above to form complexes through a precipitation process in order to increase the yield of complexes, increase the amount of guest complexed, and decrease the particle size of the compl... | 04/26/2005 |
| 6861410 | Immunological adjuvant compositions The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable ... | 03/01/2005 |
| 6835715 | Mammalian dihydroouabain-like factor and therapeutic compositions A novel mammalian dihydroouabain-like factor is disclosed which substantially fails to cross-react with mammalian ouabain-like factor (OLF) for binding to anti-OLF antibody, but cross-reacts with plant-related dihydroouabain (dho) for binding to anti-dho antibody, h... | 12/28/2004 |
