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| Number | Title | Issue Date |
| 8148503 | Nucleotides and nucleosides and methods for their use in DNA sequencing The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, ph... | 04/03/2012 |
| 8097706 | Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein The present invention relates to a method for preparing capecitabine and a method for preparing a β-anomer-rich trialkyl carbonate compound used therein, and a highly pure capecitabine can be efficiently prepared with a high yield by the method of the present inven... | 01/17/2012 |
| 8084590 | Labelled nucleotides The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group ... | 12/27/2011 |
| 8084589 | Phosphoramidite nucleoside analogs Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or severa... | 12/27/2011 |
| 8058414 | Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their ... | 11/15/2011 |
| 8003769 | Dye-labeled ribonucleotide triphosphates The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction. ... | 08/23/2011 |
| 7989599 | Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activati... | 08/02/2011 |
| 7973146 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the n... | 07/05/2011 |
| 7973145 | Sulfonated sugar compounds, pharmaceutical compositions which contain the same, and methods of treating tumors with the same Sulfoquinovosylacyl propanediol compounds represented by formula (I): wherein R1 is an acyl residue of a fatty acid, Y is a number of 1, 2 or 3, and M represents a cation having a positive charge equal to Y and p... | 07/05/2011 |
| 7956171 | Nucleotide analogs The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analog... | 06/07/2011 |
| 7897736 | Fluorescent quenching detecting reagents and methods Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group. ... | 03/01/2011 |
| 7893224 | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. ... | 02/22/2011 |
| 7847075 | 2-Azapurine compounds and their use Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaa... | 12/07/2010 |
| 7781572 | Nanosized carotenoid cyclodextrin complexes Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermedia... | 08/24/2010 |
| 7777013 | Labeled nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single bas... | 08/17/2010 |
| 7759469 | Labeling reagent The current invention restates substituted nitroindole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectab... | 07/20/2010 |
| 7759470 | Labeling reagent The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable gr... | 07/20/2010 |
| 7754864 | Tyrosinase activity controlling agent, process for producing the same and external preparation containing the same Disclosed is a tyrosinase activity controlling agent comprising, as an active ingredient, a compound that has tyrosinase inhibiting or promoting activity, an external preparation comprising the controlling agent, and a process for producing the compound. ... | 07/13/2010 |
| 7700746 | Filtration material Material characterized by that the material contains at least one biologically active di- or trisaccharide or higher oligosaccharide which is covalently bound via a spacer to cross-linked agarose. ... | 04/20/2010 |
| 7678892 | Dye-labeled ribonucleotide triphosphates The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction. ... | 03/16/2010 |
| 7662938 | 2′-fluoronucleosides A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: | 02/16/2010 |
| 7655768 | Galactose derivative, drug carrier and medicinal composition The present invention relates to a novel and useful galactose derivative constituting a drug carrier by which a medicine can be efficiently transferred into the liver, a drug carrier comprising the derivative, and a pharmaceutical composition comprising the carrier ... | 02/02/2010 |
| 7652130 | Use of alkylpolyxylosides in cosmetics A composition, method of preparation1 and use to enhance the cosmetic feel of oil-in-water emulsions based upon the addition to the oil in water emulsion of one or more alkylpolyxylosides represented by formula: R—O—(X)p, ... | 01/26/2010 |
| 7649087 | Saccharide residue-functional organopolycarbosiloxanes and method for the preparation thereof A saccharide residue-functional organopolycarbosiloxane containing at least two monosaccharide or polysaccharide groups per molecule in which a specific site on the monosaccharide or polysaccharide is bonded to silicon through a thioether bond. Also, a method of pre... | 01/19/2010 |
| 7550570 | 4,7-dichlororhodamine dyes labeled polynucleotides A set of 4,7-dichlororhodamine compounds useful as fluorescent dyes are disclosed having the structures wherein R1-R6 are hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonat... | 06/23/2009 |
| 7541444 | Modified nucleotides The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a gro... | 06/02/2009 |
| 7456266 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 11/25/2008 |
| 7442687 | 2-polycyclic propynyl adenosine analogs having A2A agonist activity The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein. ... | 10/28/2008 |
| 7439322 | Glycopeptides produced using glycosyltransferase gtfE The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and met... | 10/21/2008 |
| 7439232 | Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a heteroaryl 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, p... | 10/21/2008 |
| 7429568 | Glucopyranosyloxypyrazole derivatives and use thereof in medicines The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a gr... | 09/30/2008 |
| 7423133 | Fluorescent glycosides and methods for their use Fluorescent glycosides containing aromatic hydrocarbon groups are useful in labelling and detection methods for a wide array of chemical and biological molecules. Assembly of multiple analogs to form “polyfluors” affords fluorescence properties that are differen... | 09/09/2008 |
| 7419958 | Method of attenuating reactions to skin irritants The present invention is directed to a method of inhibiting CD1d activation by administering a composition containing a moiety that blocks CD1d activation. Compositions of the invention are useful for the attenuation of CD1d-restricted immune responses, including tr... | 09/02/2008 |
| 7419960 | Hemiterpene glycosides with anti-platelet aggregation activities from Two hitherto unreported novel hemiterpene glycosides were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of these hemiterpenes have been elucidated. These hemiterpene glycosides possess anti-pl... | 09/02/2008 |
| 7416719 | Sunscreen compositions The present invention is a sunscreen composition that has at least one sunscreen agent and at least one glucoside emulsifier. The composition also has water. Preferably, the sunscreen composition also has at least one of the following additional components: an emuls... | 08/26/2008 |
| 7417031 | Use of algae-derived physiologically active substances for treating a carcinomatous disease Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least... | 08/26/2008 |
| 7417129 | Combinatorial libraries of monosaccharides A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I. ... | 08/26/2008 |
| 7414072 | Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly... | 08/19/2008 |
| 7405281 | Fluorescent nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single bas... | 07/29/2008 |
| 7396925 | Volatilizable solid phase supports for compound synthesis A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved p... | 07/08/2008 |
