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| Number | Title | Issue Date |
| 8013147 | Heterocyclic compounds and their use in the detection of nucleic acids The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DN... | 09/06/2011 |
| 7750145 | 1-substituted-3-β-D-glucopyranosylated nitrogenous hetero-cyclic compounds and medicines containing the same A compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity, etc. It is a 1-substituted-3-(β-D-glycopyra... | 07/06/2010 |
| 7732596 | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as... | 06/08/2010 |
| 7449571 | Halogenated aminoquinolines and oligonucleotides containing the same Novel synthetic monomers that have the capacity to be assembled into defined oligomers which bind with sequence specificity to duplex Watson-Crick DNA via a triple helix motif are provided. ... | 11/11/2008 |
| 7223738 | Inhibitors of Akt activity The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 05/29/2007 |
| 7202350 | C-glycoside derivatives and salts thereof The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a ther... | 04/10/2007 |
| 7094763 | Substituted fused heterocyclic C-glycosides This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. ... | 08/22/2006 |
| 6914052 | Selective anti-viral nucleoside chain terminators The present invention relates to dideoxynucleoside analog compounds containing a dideoxy ribofuranosyl moiety that exhibit selective anti-viral activity coupled with substantially low toxicity toward the host cells. In particular, the compounds according to the pres... | 07/05/2005 |
| 6713623 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates. ... | 03/30/2004 |
| 6613896 | Method of producing tiazofurin and other C-nucleosides C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments a cyano... | 09/02/2003 |
| 6475985 | Nucleosides with antiviral and anticancer activity The invention provides nucleosides of formulae (I), (II), (V) and (VII) as described in the specification which possess antiviral and anticancer activity. Treatment of breast cancer is a preferred embodiment.... | 11/05/2002 |
| 6447998 | 2-Aminopyridine and 2-pyridone C-nucleosides, oligonucleotides comprising, and tests using the same oligonucleotides The present invention provides 2-aminopyridine and 2-pyridone C-nucleosides and oligonucleotides containing the subject nucleosides. The nucleosides are useful in the preparation of the subject oligonucleotides. The oligonucleotides are useful in oligonuc... | 09/10/2002 |
| 6376662 | Method for synthesizing C-glycosides of ulosonic acids A method for synthesizing C-glycosides of ulosonic acids such as Neu5Ac, by which diastereocontrolled synthesis of -C-glycosides of ulosonic acids is attained is disclosed. In the method of the present invention, an ulosonic acid sulfone or phosphi... | 04/23/2002 |
| 6350863 | 3, 4-di(acylamino)phenyl ribofuranosides, 2'-deoxyribofuranosides, and methods of making Provided is an artificial nucleic acid which has a double-stranded structure made of two oligonucleotides, where the oligonucleotide has in a sugar-phosphate backbone structure thereof a sugar moiety having a group having a metal-coordinating site, and th... | 02/26/2002 |
| 6326490 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.... | 12/04/2001 |
| 6294659 | Photocleavable nucleoside base and nucleic acids including The present invention relates, in general, to a nucleoside base and, in particular, to a universal, photocleavable nucleoside base. The invention further relates to oligonucleotides comprising such a base.... | 09/25/2001 |
| 6248878 | Nucleoside analogs Novel nucleoside analogs, such as 3-(ଲ-D-Ribofuranosyl)-2-fluoropyridine, 3-(ଲ-D-Ribofuranosyl)-pyridin-2-one, 3-(ଲ-D-Ribofuranosyl)-pyridin-2-(4-nitrophenylethyl)-one, 3-(-D-Ribofuranosyl)-2-fluoropyridine, 5-(ଲ-D... | 06/19/2001 |
| 6218108 | Nucleoside analogs with polycyclic aromatic groups attached, methods of synthesis and uses therefor The present invention provides fluorescent nucleosides carrying polycyclic aromatic hydrocarbons such as anthracene, phenanthrene, pyrene stilbene, tetracene or pentacene. The subject nucleosides may be synthesized using a C-glycosidic bond formation meth... | 04/17/2001 |
| 6214801 | Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to imidazo[1,2-a]pyrid... | 04/10/2001 |
| 6030952 | Benzofuran-acrylic acid derivatives and their use as modulators of RXRs or RARs receptors The present invention provides novel heteroaryl compounds having the general formula (I): ##STR1## their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respira... | 02/29/2000 |
| 5907036 | Procedures for obtaining ribo-C-nucleosides Novel procedures for obtaining ribo-C-nucleosides, including especially 2-ଲ-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-ଲ-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel p... | 05/25/1999 |
| 5844110 | Synthetic triple helix-forming compound precursors The present invention discloses novel monomeric compositions which are substituted quinoline- or quinazoline-based structures capable of hydrogen bonding specifically with interstrand purine-pyrimidine base pairs in a double-stranded Watson-Crick DNA mole... | 12/01/1998 |
| 5811540 | 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof Disclosed is a 5-O-pyrimidyl-2,3-dideoxy-1-thio-D-furanoside derivative represented by the following formula (I) or an L-form isomer thereof: ##STR1## wherein X represents a hydrogen atom, a fluorine atom or an azido group; R1 represents a... | 09/22/1998 |
| 5703224 | Antiviral c-nucleoside derivatives The present invention is composed of a nucleoside derivative of the following general formula I!: ##STR1## (wherein B represents adenin-9-ylmethyl, guanin-9-ylmethyl, hypoxanthin-9-ylmethyl, thymin-1-ylmethyl, uracil-1-ylmethyl, or cytosin-1-y... | 12/30/1997 |
| 5703093 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune res... | 12/30/1997 |
| 5525480 | N- and O-substituted aminophenols, method and use for diagnosis The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates fo... | 06/11/1996 |
| 5521162 | Aristeromycin analogues of 4',5'-didehydro-5'-fluoro-adenosine and methods of treating neoplastic and viral disease conditions This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 05/28/1996 |
| 5393879 | Fructosyl C-glycoside nucleoside analogs Nucleoside and nucleotide analogs corresponding to structural Formula I, below, are disclosed, in that structural formula, B is a ##STR1## purine base attached at the 9-position or pyrimidine base, attached at the 1-position R is hydrogen or PO3... | 02/28/1995 |
| 5302582 | Enkastins: new glycopeptides which act to inhibit enkephlinase, processes for their preparation, and their use as pharmaceutical products The invention relates to new biologically active glycopeptides of the general formula Sacch--A--B--R in which Sacch represents a monosaccharide residue with, where appropriate, the OH groups being partially or completely substituted, A represents the residue o... | 04/12/1994 |
| 5221738 | cDNA and genomic DNA encoding the amino acid sequence of human 2 -plasmin inhibition cDNA encoding a human 댒 -plasmin inhibitor precursor protein represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; an amino acid sequence of a human 댒 -plasmin... | 06/22/1993 |
| 5217961 | Condensed quinoline system N-glycosides The present invention provides condensed quinoline compounds represented by the following general formula (I): ##STR1## in which Z is NH, X is hydrogen, L is lower alkoxy, M is NHQ, Q is --SO2 CH3, Y is --NHR, and R is: ##S... | 06/08/1993 |
| 5137876 | Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same The compound having the formula: ##STR1## has antiviral activity, specifically in the prevention or treatment of infection by retroviruses, including HIV, and immunosuppressive activity, either as a compound, pharmaceutically acceptable salt, or a ... | 08/11/1992 |
| 5126442 | Advanced glycosylation endproducts and associated methods New and useful chromophores have been isolated from the reaction mixture of proteins exposed to reducing sugars in the presence of sulfite over time. The chromophores are believed to be intermediates in nonenzymatic polypeptide glycosylation. The measurem... | 06/30/1992 |
| 5089045 | Substituted 3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepine-8-ol herbicides Herbicidal 3,6,7,8-tetrahydroimidazo[4,5-d]-[1,3]diazepin-8-ol derivatives of the formula: ##STR1## and sugar conjugates thereof, compositions containing them, and a process for their preparation.... | 02/18/1992 |
| 5082934 | Coumarin derivatives for use as nucleotide crosslinking reagents A photoactivatible nucleoside analogue is disclosed, comprising a coumarin moiety linked through its phenyl ring to the 1-position of a ribose or deoxyribose sugar moiety. The resulting nucleoside analogue is typically used as a photocrosslinking group wh... | 01/21/1992 |
| 4918056 | 2-substituted arabinopyranosyl nucleosides and nucleotides Novel arabinopyranosyl nucleoside derivatives having the heterocyclic moiety and fluorine at the 2' position of the sugar ring (pyranose configuration), which have antitumor, antiviral and antimicrobial properties, are prepared by condensation of a pyrimi... | 04/17/1990 |
| 4656260 | Cyclic pyrazolo C-nucleoside compound and process for preparing the same A novel compound, 3-(ଲ-D-ribofranosyl)pyrazolo-[3,4-e] [1,3]oxazine-5,7-dione, exhibiting a function of inhibiting propagation or growth of various virus, and a process for preparing the same.... | 04/07/1987 |
| 4619996 | Process for preparing 2-ଲ-D-ribofuranosylselenazole-4-carboxamide A chemical process for preparing 2-ଲ-D-ribofuranosylselenazole-4-carboxamide, comprises reacting 2,3,5-tri-O-benzoyl-ଲ-D-ribofuranosyl-1-carbonitrile with gaseous hydrogen selenide in a polar organic solvent.... | 10/28/1986 |
| 4402945 | Glycoside derivatives of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline and pharmaceutical compositions containing same The invention provides new glycoside derivatives of 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline, to the production thereof and to their use as biological antioxidants, to protect vitamin E-deficient animals and as growth promoting agents.... | 09/06/1983 |
| 4402947 | Pesticidally active nikkomicin heavy metal salts Arthropodicidally and fungicidally active heavy metal salts of nikkomicin are produced by reacting nikkomicin with a water-soluble heavy metal salt in an aqueous medium.... | 09/06/1983 |
