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| Number | Title | Issue Date |
| 7851618 | Aminated complex-type sugar chain derivatives and process for the production thereof An aminated complex-type oligosaccharide derivative of the formula (1) wherein R1 is H—(CO)—CH2X, —NH—(CO)—(CH2)b—CH2X, isothiocyanate group, —NH—(CO) | 12/14/2010 |
| 7838665 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 11/23/2010 |
| 7781577 | Inhibitors of sodium glucose co-transporter 2 and methods of their use Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity. ... | 08/24/2010 |
| 7754874 | Neoglycorandomization and digitoxin analogs The present invention provides methods of producing libraries of compounds with enhanced desirable properties and diminished side effects as well as the compounds produced by the methods. In preferred embodiments, methods of the present invention use a universal che... | 07/13/2010 |
| 7393938 | Use of lipid conjugates in the treatment of diseases This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothi... | 07/01/2008 |
| 7169392 | serogroup B glycoconjugates and methods of producing the same The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (Men... | 01/30/2007 |
| 7153498 | Water-in-oil emulsion and its use as a cosmetic A composition, comprising, in a physiologically acceptable medium, an aqueous phase dispersed in an oily phase by means of an emulsifier of at least one oligomer or one polymer derived from a polyolefin, comprising a polyolefinic apolar component comprising at least... | 12/26/2006 |
| 7138384 | Modulators of DNA cytosine-5 methyltransferase and methods for use thereof A synthetic oligonucleotide comprising a C-5 methylcytosine and which recognizes and binds an allosteric site on DNA methyltransferase thereby inhibiting DNA methyltransferase activity is disclosed. Also disclosed is a composition comprising a synthetic oligonucleot... | 11/21/2006 |
| 7101859 | Use of lipid conjugates in the treatment of diseases The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomer... | 09/05/2006 |
| 7063949 | Methods for isolating molecular mimetics of unique serogroup B epitopes Novel bactericidal antibodies against Neisseria meningitidis serogroup B (“MenB”) are disclosed. The antibodies either do not cross-react or minimally cross-react with host tissue polysialic acid and hence pose minimal risk of autoimmune activity. The ant... | 06/20/2006 |
| 7033612 | Composition and method for treating age-related disorders There is provided a composition for the prevention and treatment of age-related physical and mental disorders that includes phospholipids that have been extracted from chick embryos aged between about 6 days old and about 14 days old. Also provided is a method for e... | 04/25/2006 |
| 7034006 | Use of lipid conjugates in the treatment of disease The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomer... | 04/25/2006 |
| 7022830 | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and pept... | 04/04/2006 |
| 6979676 | Pharmaceutical composition containing and indolopyrrolocarbazole derivative The present invention is directed to a pharmaceutical composition comprising a compound of Formula I dissolved in propylene glycol and water. The present invention also relates to a pharmaceutical composition containing a compound of Formula I dissolved in propylene... | 12/27/2005 |
| 6960569 | Hepatitis C virus non-structural NS3/4A fusion gene Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the inevntion include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nuclei... | 11/01/2005 |
| 6949524 | Polysaccharide conjugates of biomolecules Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccha... | 09/27/2005 |
| 6897199 | Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceuticall... | 05/24/2005 |
| 6858590 | Vaccines containing ribavirin and methods of use thereof Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope presen... | 02/22/2005 |
| 6815441 | Reaction products of taurultam and glucose Reaction products of taurultam and glucose are useful as antineoplastic agents. They are produced by reacting an aqueous solution of taurultam and glucose at about 100 degrees Celsius for about 30 minutes, yielding a reaction product which has a melting point of 168... | 11/09/2004 |
| 6790837 | Ribavirin syrup formulations A liquid formulation comprising ribavirin having a longer shelf life and improved taste is disclosed. ... | 09/14/2004 |
| 6693085 | Macrolide compound JK Compound JK represented by the general formula (1): ##STR1## wherein R is H or --CH3 ; or a pharmaceutically acceptable salt thereof. Compound JK has an excellent antimicrobial activity even against resistant strains including MRSA and is useful as ... | 02/17/2004 |
| 6664388 | Reagents for oligonucleotide cleavage and deprotection The present invention provides a process for the removal of protecting groups, i.e. deprotection, from chemically synthesized oligonucleotides. In one embodiment, the invention provides reagents suitable for use in such a process, and kits incorporating s... | 12/16/2003 |
| 6664243 | Benzyllactobionamides as inhibitors of smooth muscle cell proliferation This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure ##STR1## wherein R1 -R13 are as defined herein.... | 12/16/2003 |
| 6635622 | Glycolipid derivative The present invention is a compound of general formula (I) or a pharmaceutically acceptable salt of, ##STR1## wherein W represents carbon chain from 9 to 17 which containing double bond or hydroxy group occasionally; X represents carbon chain from 11 to 2... | 10/21/2003 |
| 6559299 | Preparation and isolation of indolocarbazole glycosides The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.... | 05/06/2003 |
| 6555677 | Phase transfer catalyzed glycosidation of an indolocarbazole The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, an... | 04/29/2003 |
| 6531454 | Glycosylated polyamines and methods of use therefor Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has the fo... | 03/11/2003 |
| 6420344 | Glycosylated polyamines Glycosylated polyamines comprising of mono- or oligo-saccharides that are glycosidically linked to an aliphatic polyamine, and pharmaceutically acceptable salts, prodrugs and derivatives thereof are provided. An exemplary glycosylated polyamine has the fo... | 07/16/2002 |
| 6384211 | Carbopeptoids and carbo-nucleotoids Libraries are synthesized with oligomeric carbopeptoids and carbonucleotoids. Carbopeptoids are oligosaccharides having carbohydrate subunits linked to one another by amide bonds. Carbonucleotoids are oligosaccharides having carbohydrate subunits linked t... | 05/07/2002 |
| 6362170 | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure ##STR1## wherein Y is C or N; where n is 0-3; X is ##STR2## R1, and R2 are each independently, hydrogen, alkyl of 1 to 6 carbo... | 03/26/2002 |
| 6339064 | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure ##STR1## wherein Y is C or N; where n is 0-3; X is ##STR2## R1, and R2 are independently, hydrogen, alkyl of 1 to 6 carbon ato... | 01/15/2002 |
| 6288041 | Sialic acid derivatives Sialic acid derivatives represented by the following general formula: ##STR1## wherein R1 represents a residue of a steroid compound excluding cholestane and cholestene residues, R2 represents hydrogen or methyl group, R3 ... | 09/11/2001 |
| 6228998 | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide A glycosaminoglycan derivative is disclosed wherein a first amino group of a spacer compound (NH2 --Y--NH2) is bonded to an aldehyde formed by reducing and partially oxidizing a reducing end sugar of a glycosaminoglycan, via an amino... | 05/08/2001 |
| 6204376 | Carbopeptoids and carbonucleotoids Libraries are synthesized with oligomeric carbopeptoids and carbonucleotoids. Carbopeptides are oligosaccharides having carbohydrate subunits linked to one another by amide bonds. Carbonucleotoids are oligosaccharides having carbohydrate subunits linked t... | 03/20/2001 |
| 6201116 | Halide indicators The invention provides methods and compositions for measuring ion concentration inside a cell by measuring fluorescence of a compound of the general formula I. In particular embodiments, the measured ion is halide, particularly iodide, the cell contains a... | 03/13/2001 |
| 6177074 | Polyethylene glycol modified interferon therapy A method comprising administering a PEG12000 -IFN alpha conjugate to an individual afflicted with a viral infection susceptible of treatment with interferon alpha, preferably chronic hepatitis C, is disclosed.... | 01/23/2001 |
| 6160110 | Amino acid copolymers having pendent polysaccharide moieties and uses thereof A water-soluble or water-dispersible amino acid copolymer having pendent polysaccharide moieties. The invention also provides a method for cleaning an article and a method of providing soil resistance to an article using the amino acid copolymer having pe... | 12/12/2000 |
| 6150337 | Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes Ribavirin is employed in a manner which is effective to modulate lymphokine expression in activated T cells. In particular, Ribavirin is used to suppress Type 2-mediated T cell responses and promote Type 1-mediated T cell response. Thus, instead of admini... | 11/21/2000 |
| 6120997 | Nucleic acid binders having an hydroxyamine motif The invention relates to the combination of hydroxyamines with nucleic acid binding motifs to generate molecules and libraries of molecules targeting specific nucleic acid sequences. In particular, a series of libraries are constructed which contain hydro... | 09/19/2000 |
| 6111084 | Fuopeptide mimetics Bioactive fucopeptides and libraries of fucopeptides having advanced activities against P-selectin as sialyl Lewis X mimetics with IC50 values in the low mM range are synthesized by solid phase synthesis using para-acyloxymethylenzlidene acetal... | 08/29/2000 |
