Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7235647 | Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically accept... | 06/26/2007 |
| 7148207 | Oral fludara of high-purity formulation with quick release of active ingredient This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants. ... | 12/12/2006 |
| 7119096 | Uracil reductase inactivators Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 ... | 10/10/2006 |
| 6884880 | Process for the preparation of 9-β-anomeric nucleoside analogs A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-β-D- or L-purine nucleoside analog... | 04/26/2005 |
| 6699978 | Linker nucleoside, and production and use of the same The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.... | 03/02/2004 |
| 6593467 | Process for the preparation of a deoxyuridine derivative A process for the preparation of 5'-deoxy-5-fluorouridine, which comprises the transformation of 2',3'-O-isopropylidene-5-fluorouridine in the corresponding 5'-O-sulfonyl derivative, subsequent reaction with alkaline or earth-alkaline iodides and, after h... | 07/15/2003 |
| 6569837 | ଲ-L-2'-deoxy pyrimidine nucleosides for the treatment of hepatitis B This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2'-deoxy-ଲ-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or ... | 05/27/2003 |
| 6482805 | AZT derivatives exhibiting spermicidal and anti-viral activity Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient conta... | 11/19/2002 |
| 6458772 | Prodrugs Compounds of the formula I ##STR1## or corresponding monohydroxynucleoside derivatives wherein: R1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon; a C4 -C22 saturated or unsaturated, optionally ... | 10/01/2002 |
| 6407078 | AZT derivatives exhibiting spermicidal and anti-viral activity Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient conta... | 06/18/2002 |
| 6392032 | Heavily fluorinated sugar analogs Heavily fluorinated sugar analogs of formula ##STR1## wherein R1 is selected from alkyl, alkenyl, aryl, --CH2 --O-alkyl, --CH2 --O-aryl, --CH2 OPO3 H, --CH2 --O-carbohydrate, --CH2 | 05/21/2002 |
| 6339151 | Enzyme catalyzed therapeutic agents This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expres... | 01/15/2002 |
| 6297223 | Uracil reductase inactivatores Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-fluorouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, iodo, cyano, halo-substituted C | 10/02/2001 |
| 6258360 | Prodrugs activated by targeted catalytic proteins Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.... | 07/10/2001 |
| 6225450 | DNA sequencing by mass spectrometry The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and ... | 05/01/2001 |
| 6211166 | 5'-deoxy-cytidine derivative administration to treat solid tumors Novel 5'-deoxy-cytidine derivatives represented by the general formula (I) ##STR1## wherein R1 is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R2 is a hydrogen atom, or --CO--OR4 group [wh... | 04/03/2001 |
| 6191120 | Spermicidally active 5-halo-6-alkoxy-5,6-dihydro-2',3'-dideoxy-uridines and their pharamaceutical compositions Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient conta... | 02/20/2001 |
| 6175001 | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same Modified pyrimidine nucleotides derivatized at C5 to contain a functional group that mimics the property of a naturally occurring amino acid residues are provided. DNA molecules containing the modified nucleotides are also provided.... | 01/16/2001 |
| 6060592 | Pyrimidine nucleoside compounds and oligonucleoside compounds containing same Novel 2- and 4-substituted pyrimidine nucleosides and oligonucleosides are provided, as are methods and intermediates useful in preparing same. In preferred embodiments, one of the 2- and 4-substituents is .dbd.O, .dbd.NH, or .dbd.NH2+ | 05/09/2000 |
| 6040298 | Methods for treatment with compositions effective against acyclovir-resistant strains of herpes viruses The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by herpes virus strains that are resistant to treatment with acyclovir. In particular, it has been discovered t... | 03/21/2000 |
| 6020483 | Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ... | 02/01/2000 |
| 6013790 | Heavily fluorinated sugar analogs Heavily fluorinated sugar analogs of formula ##STR1## wherein R1 is selected from alkyl, alkenyl, aryl, CH2 OH, --CH2 --O-alkyl, --CH2 --O-aryl, --CH2 OPO3 H, --CH2 --O-carb... | 01/11/2000 |
| 5985849 | Phosphate compounds and their use as medicaments A compound of the formula (I) or salts thereof: ##STR1## wherein X, R1, Q1 and Q2 are as defined in the specification. The compounds have been found to be P2 7-TM G-protein receptor antagonists, especially to the P2 Y... | 11/16/1999 |
| 5968910 | Compositions containing two or three inhibitors of different HIV reverse transcriptases A composition and method for the prevention or treatment of HIV-1 infection comprising an HIV-1 reverse transcriptase-inhibiting heterocyclyl carb(ox/thio)anilide compound, a second HIV-1 reverse transcriptase inhibitor compound which does not select for ... | 10/19/1999 |
| 5959100 | Pyrimidine nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidin... | 09/28/1999 |
| 5945527 | Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide This invention discloses a method for the preparation modified nucleosides and nucleotides using a palladium catalyst, a nucleophile and carbon monoxide.... | 08/31/1999 |
| 5905070 | 5--Caboxamido or 5--fluoro!--2', 3'--unsaturated or 3'--modified!--pyrimidine nucleosides A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a 5-carboxamido or 5-fluoro!-2',3'-dideoxy-2',3'-didehydro-pyrimidine nucleosid... | 05/18/1999 |
| 5869464 | 2'-Deoxy-5-fluorouridine derivatives, a process for their preparation, antitumor agents containing same and methods for using said agents The compounds of the invention are a 2'-deoxy-5-fluorouridine derivative represented by the formula ##STR1## wherein one of R1 and R2 is a hydrogen atom or a group easily hydrolyzable in vivo, the other is a benzyl group which m... | 02/09/1999 |
| 5843917 | 5-Fluorouracil derivatives Novel compounds comprising 5-fluorouracil or 5-fluorouridine covalently linked to 5-ethynyluracil, 5-ethynyluridine or 5-propynyluracil and pharmaceutical compositions comprising such compounds are disclosed.... | 12/01/1998 |
| 5817639 | Purine 4'-thioarabinonucleosides The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula 1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a method for preparing the purine 4'-thioarabinonucle... | 10/06/1998 |
| 5811540 | 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof Disclosed is a 5-O-pyrimidyl-2,3-dideoxy-1-thio-D-furanoside derivative represented by the following formula (I) or an L-form isomer thereof: ##STR1## wherein X represents a hydrogen atom, a fluorine atom or an azido group; R1 represents a... | 09/22/1998 |
| 5808049 | Stereospecific 5-fu esters and methods for preparing same There is disclosed an ester compound that is resistant to decomposition in blood, but is quickly hydrolyzed in cancer cells, and functions as an anticancer agent. The ester compound has a structure represented by formula (I) or formula (II): ##STR1##... | 09/15/1998 |
| 5798340 | Nucleotide analogs Nucleotide analogs characterized by the presence of an amidate lirked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is h... | 08/25/1998 |
| 5792841 | 2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, uridine and guanosine derivatives This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease stat... | 08/11/1998 |
| 5792773 | L-ଲ-dioxolane uridine analog administration for treating Epstein-Barr virus infection The present invention relates to the discovery that certain ଲ-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In partic... | 08/11/1998 |
| 5789387 | Methods and compositions for treating fungal infections in mammals Methods of treating fungal infections are disclosed. The methods comprise administering a chitin synthesis inhibitor to a mammal in a continuous fashion so that at least a minimum effective concentration is maintained in the mammal's plasma or in a target... | 08/04/1998 |
| 5783689 | Antibacterial and antifungal nucleosides 5'-O-Acyl-5-fluorouridines and 5'-O-acyl-5-sluorocytidines are prepared by the direct acylation of the 5'-hydroxyl group with amino acids under Mitsunobu conditions and the amino acyl derivatives are coupled with other amino acids or peptides to provide a... | 07/21/1998 |
| 5763418 | 3'-substituted nucleoside derivatives The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z represents a lower alkynyl or lower alkenyl group which may... | 06/09/1998 |
| 5719132 | Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil The present invention is directed to the use of pharmaceutical compositions containing anti-retroviral effective amounts of (a) d4T and (b) 5-fluorouracil or a prodrug, or salt thereof.... | 02/17/1998 |
| 5719273 | Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide This invention discloses a method for the preparation modified nucleosides using a palladium catalyst, a nucleophile and carbon monoxide.... | 02/17/1998 |
