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| Number | Title | Issue Date |
| 7429572 | Modified fluorinated nucleoside analogues The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deo... | 09/30/2008 |
| 7332477 | Photocleavable DNA transfer agent The present invention provides visible light sensitive and ultraviolet (UV) light sensitive composition for DNA transfer comprising acid sensitive polyacetals developed as DNA/RNA delivery agents, a photoacid generator and optionally a photosensitizer. ... | 02/19/2008 |
| 7214791 | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material The present invention provides a method for preparation of 2′-deoxy-2′,2′-difluoro-β-cytidine or pharmaceutically acceptable salt thereof, comprising starting from 1,6-anhydro-β-D-glucose as raw material, oxidizing, and fluorinating to obtain 2-deoxy-2,2-dif... | 05/08/2007 |
| 7078518 | Forms of 5-Azacytidine The disclosure includes novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The disclosure... | 07/18/2006 |
| 7038038 | Synthesis of 5-azacytidine The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylat... | 05/02/2006 |
| 6887855 | Forms of 5-azacytidine The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also incl... | 05/03/2005 |
| 6858591 | Antibiotic AA 896 analogs The invention provides compounds of the Formula 1 wherein the definitions of m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, ... | 02/22/2005 |
| 6784161 | Method for the treatment or prevention of flavivirus infections using nucleoside analogues The present invention relates to a method for the treatment or prevention of Flavivirus infections using nucleoside analogues in a host comprising administering a therapeutically effective amount of a compound having the formula I or a pharmaceutically acceptable sa... | 08/31/2004 |
| 6504024 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 01/07/2003 |
| 6184364 | High affinity nucleic acid ligands containing modified nucleotides Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic aci... | 02/06/2001 |
| 6040298 | Methods for treatment with compositions effective against acyclovir-resistant strains of herpes viruses The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by herpes virus strains that are resistant to treatment with acyclovir. In particular, it has been discovered t... | 03/21/2000 |
| 6020483 | Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ... | 02/01/2000 |
| 5959100 | Pyrimidine nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidin... | 09/28/1999 |
| 5821356 | Propargylethoxyamino nucleotides Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 | 10/13/1998 |
| 5644043 | 2',3'-dideoxy-2',2'-difluoronucleosides and intermediates This invention provides 2',3'-dideoxy-2',2'-difluoronucleosides of the structure ##STR1## wherein R1 -R4 are defined in the specification. These compounds have been shown to be useful for treating a variety of vital infections i... | 07/01/1997 |
| 5633367 | Process for the preparation of a 2-substituted 3,3-difluorofuran A process for the preparation of a 2-substituted-3,3-difluorofuran using diethyl ammonium sulfur trifluoride (DAST) and pyridine hydrogen fluoride. The process is particularly useful for producing a 2',2'-difluoronucleoside, particularly 1-(2',2'-dif... | 05/27/1997 |
| 5614617 | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides a... | 03/25/1997 |
| 5606048 | Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides A stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides by reacting a concentrated alpha- or beta-anomer enriched 2 -deoxy-2,2-difluorocarbohydrate or 2-deo... | 02/25/1997 |
| 5455234 | Inhibition of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cysteine synthetic pathway enzyme.... | 10/03/1995 |
| 5434254 | Process for preparing 2',2'-difluoronucleosides The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enan... | 07/18/1995 |
| 5426183 | Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides A catalytic stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides involving reacting an alpha- or beta- anomer enriched 2-deoxy-2,2-difluorocarbohydrate or ... | 06/20/1995 |
| 5393878 | Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates Compounds of the formula I in the form of the racemates or enantiomers thereof, ##STR1## in which R1 and R2 independently of one another are hydrogen or a protective group, and B is a purine or pyrimidine radical or an analogue ... | 02/28/1995 |
| 5371210 | Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides A stereoselective fusion glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides is provided which requires reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-... | 12/06/1994 |
| 5276020 | Anti-virals Anti-virals wherein a linoleyl, gamma-linolenyl or other unsaturated long chain fatty acyl group is borne directly on a hydroxy or amino group of the sugar/sugar analogue or heterocyclic moiety of a nucleoside or nucleoside analogue.... | 01/04/1994 |
| 5212294 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially a... | 05/18/1993 |
| 5130421 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially a... | 07/14/1992 |
| 4908440 | 2',3'-dideoxy-2'-fluoroarabinopyrimidine nucleosides There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV ef... | 03/13/1990 |
| 4814438 | Immunoglobulin conjugates of 2',2'-difluronucleosides Immunoglobulin conjugates are formed by reacting a difluoronucleoside with an immunoglobulin via an alkane dioic acid linking group.... | 03/21/1989 |
| 4684630 | Method of parenterally delivering drugs and related compositions A method of parenterally delivering aqueously unstable drugs that includes the aqueous dilution of a stable, anhydrous organic solution having the drug dissolved therein. The resulting organic-aqueous solution is physiologically suitable for parenteral de... | 08/04/1987 |
| 4666892 | Method and composition for hepatitis treatment with pyrimidine nucleoside compounds The invention relates to 5-substituted-1-(2'-deoxy-2'-substituted-beta-D-Arabinofuranoysyl) pyrimidine compounds and their use in a method for the treatment of hepatitis B viruses.... | 05/19/1987 |
| 4489052 | Quantitative autoradiographic mapping of focal herpes simplex virus encephalitis using a radiolabeled antiviral drug A method of mapping herpes simplex viral infection comprising administering a radiolabeled antiviral active 5-substituted 1-(2'-deoxy-2'-substituted-D-arabinofuranosyl) pyrimidine nucleoside to the infected subject, and scanning the area in which the infe... | 12/18/1984 |
| 4423212 | Nucleosides and process Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.... | 12/27/1983 |
| 4405611 | Bisulfite stabilization of 5-azacytidine A bisulfite addition product of 5-azacytidine and method wherein bisulfite is added to the azacytidine molecule at the 5-6 protonated imine bond. It is significant and advantageous to maintain the compound in this pro-drug form. At a pH above 6 and includ... | 09/20/1983 |
| 4211773 | 5-Substituted 1-(2'-Deoxy-2'-substituted-ଲ-D-arabinofuranosyl)pyrimidine nucleosides Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula ##STR1## wherein A is OR3, SR3, NR3 R4 or NHacyl wherein R3 and R4 are the same or different and ar... | 07/08/1980 |
| 4171431 | Nucleosides and process Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.... | 10/16/1979 |
| 4140850 | 2,2'-Anhydrotriazine nucleosides and process for preparing the same Novel anhydroarabinofuranosyldihydrotriazine nucleosides and process for preparing the same. The compounds of formula I are useful as immunosuppressive agents in humans and are also active in vitro against various susceptible Herpes Viruses.... | 02/20/1979 |
| 4109078 | N-(Polysaccharidyl)-nitrogen heterocycles, especially pyrimidine or purine bases, and process for their preparation Nucleosides of the formula ##STR1## wherein Z is a free or blocked polysaccharide residue; X is O or S; m is 0 or 1; M1 is 0 or 1; R1 and R2 collectively are a saturated or unsaturated, optionally substituted bivalent orga... | 08/22/1978 |
| 4082911 | Process for the preparation of nucleosides The use of trialkylsilyl ester catalysts in place of Lewis acid or Friedel-Crafts catalysts in nucleoside synthesis gives increased yields and a simplified working-up process for recovering the nucleoside product.... | 04/04/1978 |
| 4058602 | Synthesis, structure, and antitumor activity of 5,6-dihydro-5-azacytidine The compound 5,6-dihydro-5-azacytidine, 5AC[H], and non-toxic acid addition salts such as the hydrochloride, together with its preparation from 5-azacytidine (5-AC) by reduction of the 5,6-double bond of 5-AC with an alkali metal borohydride such as sodiu... | 11/15/1977 |
| 4022963 | Acetylation process for nucleoside compounds A method of acetylation of all the hydroxyl groups in the sugar portion of nucleosides which comprises adding acetic acid to a nucleoside to be acetylated in a vessel provided with a reflux condenser, and heating the mixture in the absence of a catalyst u... | 05/10/1977 |
