Celebrity Inventors
Superstar singer Michael Jackson co-patented a "Method and means for creating anti-gravity illusion" in 1993.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7816513 | Inosine derivatives and production methods therefor The present invention provides a method for producing an inosine derivative represented by the following general formula (1) including the steps of subjecting an inosine derivative of general formula (3) to dithiocarbonylation and carrying out radical reduction of t... | 10/19/2010 |
| 7495095 | Thionucleoside-S-nitrosyl derivative The present invention provides a thionucleoside-S-nitrosyl derivative of the following Formula I or a salt thereof: [wherein R1 represents ribose, 2-deoxyribose or a derivative of either, and R2 repres... | 02/24/2009 |
| 7358235 | Analogs of nitrobenzylthioinosine Analogs or derivatives of nitrobenzylthioinosine compounds. The use of these new analogs of nitrobenzylthioinosine and methods for the treatment of pain and various other indications using these analogs of nitrobenzylthioinosine as well as pharmaceutical composition... | 04/15/2008 |
| 7323451 | Crystalline and amorphous forms of beta-L-2′-deoxythymidine Physical forms of beta-L-2′-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, thermal properties, and methods of manufacture. These forms of beta-L-2â€... | 01/29/2008 |
| 7307166 | Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoiet... | 12/11/2007 |
| 7247721 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 07/24/2007 |
| 6914138 | Urea nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidine ring, wit... | 07/05/2005 |
| 6906190 | Inhibitors for de novo-RNA polymerases and methods of identifying targets for same A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated wi... | 06/14/2005 |
| 6903079 | Nucleoside compounds and compositions thereof The invention provides a novel class of substituted nucleoside derivatives having the formula: A-Z1-L-Z2-G wherein: A and G are connected via Z1 and Z2 respectively, to a linker, L; and A i... | 06/07/2005 |
| 6900307 | 2-aminopurine derivatives There are provided 2-aminopurine derivatives represented by the following general formula (1): where R represents any species selected from the group consisting of hydrogen and acyl groups, X represents any species sel... | 05/31/2005 |
| 6699978 | Linker nucleoside, and production and use of the same The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.... | 03/02/2004 |
| 6677345 | Cyclin dependent kinase inhibitors A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment of tumours or other cell proliferation disorders. The compou... | 01/13/2004 |
| 6646118 | Solid phase synthesis The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis... | 11/11/2003 |
| 6620796 | Combinatorial library synthesis and pharmaceutically active compounds produced thereby The invention provides new methods for synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and a... | 09/16/2003 |
| 6596858 | Process for the production of 2-halo-6-aminopurine derivatives A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents ... | 07/22/2003 |
| 6579976 | Process for producing 2',3'-diethyl substituted nucleoside derivatives There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or... | 06/17/2003 |
| 6555676 | Biologically active phosphotriester-type compounds Compounds of formula RS--P(.dbd.O)(QR)--Nu where: R is a radical --(CH2)n--W--X; X is a radical --C(.dbd.Z)(Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted wi... | 04/29/2003 |
| 6531589 | Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable und... | 03/11/2003 |
| 6528042 | Compositions of flavonoids for use as cytoprotectants and methods of making and using them Non-naturally-occurring compositions for use in amelioration of disruption of energy metabolism secondary to stress are described. These compositions comprise a flavonoid or derivative thereof and a synergist. Synergists include, but are not limited to, a... | 03/04/2003 |
| 6506888 | 2'-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.... | 01/14/2003 |
| 6504024 | Propargylethoxyamino nucleotide primer extensions Propargylethoxyamino nucleosides are disclosed having the structure ##STR1## wherein R1 and R2 are --H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is --H or --OH; W2 i... | 01/07/2003 |
| 6500946 | Methods for producing nucleoside derivatives and intermediates therefor Novel intermediates of nucleoside derivatives, of which the 6-position of the nucleic acid base moiety is substituted with a halogen atom, are produced. Using those novel intermediates, even substrates, of which the 3'-position of the saccharide moiety is... | 12/31/2002 |
| 6498149 | Natural antitumor or antiviral substances and use of the same The present invention provides substances having an efficacy against tumors and viruses on which the conventional anti-tumor agents and anti-virus agents exhibit only insufficient effects, and having carcinostatic effect and anti-virus effect on various r... | 12/24/2002 |
| 6495528 | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.... | 12/17/2002 |
| 6479463 | Purine L-nucleosides, analogs and uses thereof Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositi... | 11/12/2002 |
| 6444652 | ଲ-L-2'-deoxy-nucleosides for the treatment of hepatitis B This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2'-deoxy-ଲ-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or ... | 09/03/2002 |
| 6441161 | Urea nucleosides as therapeutic and diagnostic agents Modified nucleosides and methods of making and using the nucleosides are disclosed. The compounds can be prepared by reacting nucleoside starting materials that contain a suitable leaving group at one or more of the carbon atoms in the purine or pyrimidin... | 08/27/2002 |
| 6429309 | Solid phase synthesis The present invention relates to a support system for the solid phase synthesis of oligomers, such as oligonucleotide, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthe... | 08/06/2002 |
| 6395716 | ଲ-L-2'-deoxy-nucleosides for the treatment of hepatitis B This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2'-deoxy-ଲ-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or ... | 05/28/2002 |
| 6333315 | 4'-C-ethynyl purine nucleoside compounds The invention provides 4'-C-ethynyl purine nucleosides represented by formula [I]: ##STR1## wherein B represents a base selected from the group consisting of purine and derivatives thereof; X represents a hydrogen atom or a hydroxyl group; and R repr... | 12/25/2001 |
| 6297222 | Acyl deoxyribonucleoside derivatives and uses thereof The invention relates to compositions comprising acyl derivatives of 2'-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healin... | 10/02/2001 |
| 6271358 | RNA targeted 2'-modified oligonucleotides that are conformationally preorganized 2'-O-modified ribosyl nucleosides and modified oligonucleotides containing such nucleotides are disclosed. Oligonucleotides are disclosed that have increased binding affinity as shown by molecular modeling experiments. The 2'-O-modified nucleosides of the... | 08/07/2001 |
| 6265558 | Thiol-derivatized nucleosides and oligonucleosides Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention further include s... | 07/24/2001 |
| 6262254 | 8-fluoropurine compounds An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent ... | 07/17/2001 |
| 6252061 | Process for the production of 2-halo-6-aminopurine derivatives A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents ... | 06/26/2001 |
| 6207650 | Antiviral, highly water soluble, stable, crystalline salts of 2', 3'-dideoxyinosine, 2', 3'-dideoxy-2', 3'-didehydrothymidine and 2', 3'-dideoxy-2'-fluoroinosine Provided are very highly water soluble, stable, crystalline salts of 2',3'-dideoxy-2',3'-didehydrothymidine ("d4T"), 2',3'-dideoxyinosine ("ddI"), and 2',3'-dideoxy-2'-fluoroinosine ("F-ddI"). Such salts are useful as intermediates or as antiviral agents.... | 03/27/2001 |
| 6194390 | Procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effecti... | 02/27/2001 |
| 6172209 | Aminooxy-modified oligonucleotides and methods for making same Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups (such as 2'-aminooxy groups) for increasing binding affinity to complementary strand, and subsequences of 2'-deoxy-erythro-pentofuranosyl n... | 01/09/2001 |
| 6166199 | N-2 substituted purines This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents--agents that are capable of specific hybridizatio... | 12/26/2000 |
| 6159951 | 2'-O-amino-containing nucleoside analogs and polynucleotides Novel nucleoside or nucleotide analogs comprising 2'-O-amino residues, processes for their synthesis and incorporation into polynucleotides.... | 12/12/2000 |
