Class 536/27.62 - Nitrogen, chalcogen, or additional carbon bonded directly to the 6-position nitrogen (e.g., 6-position nitrogen is substituted, etc.)

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 151
Last issue date: 03/31/2009

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Number	Title	Issue Date
7511133	Adenosine Areceptor agonists The compounds of the following formula: wherein Ar, R and R1 have the meanings given in the specification. This series of sulfonamido derivatives with a conserved uronamide group at the 5...	03/31/2009
7423144	Purine Derivatives as adenosine Areceptor agonists and methods of use thereof The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or p...	09/09/2008
7414036	Compounds useful as Aadenosine receptor agonists Adenosine analogue-type A3 receptor agonists having the formula wherein D is N or CH; E is O; X1 is a group of the formula —CR20R2 1-CYCLE, where	08/19/2008
7342003	Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated,...	03/11/2008
7300923	Partial and full agonists of A1 adenosine receptors Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infa...	11/27/2007
7271157	Aadenosine receptor agonists Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonist having the structure of Formula I: wherein R is optionally subst...	09/18/2007
7265111	Adenosine analogues and their use as pharmaceutical agents The present invention relates to compounds according to the general formula (I) wherein X is selected from the group consisting of wherein n and p are indepe...	09/04/2007
7238676	Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and composition...	07/03/2007
7217815	2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula...	05/15/2007
7214665	2-propynyl adenosine analogs having Aagonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ...	05/08/2007
7199127	Purine nucleosides Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof:	04/03/2007
7189706	C2,5′-disubstituted and N,C2,5′-trisubstituted adenosine derivatives and pharmaceutical compositions containing them The present invention concerns novel C2,5′-disubstituted and N6,C2,5′-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adenosine receptor agonists and thus are of a therapeutic value in...	03/13/2007
7163928	Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ...	01/16/2007
7157440	Partial and full agonists of A1 adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ...	01/02/2007
7084127	C2,5′-disubstituted and N, C2,5′-trisubstituted adenosine derivatives and their different uses The present invention concerns novel C2,5′-disubstituted and N6′,C2,5′-trisubstituted adenosine derivatives and their different uses. These adenosine derivatives were found to be potent adenosine receptor agonists and thus are of a therapeutic value...	08/01/2006
7022727	Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a...	04/04/2006
6995148	Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor agonists and ganglionic blocking agents. To achieve this functionality, ...	02/07/2006
6921753	Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions cont...	07/26/2005
6914061	4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3,...	07/05/2005
6903079	Nucleoside compounds and compositions thereof The invention provides a novel class of substituted nucleoside derivatives having the formula: A-Z1-L-Z2-G wherein: A and G are connected via Z1 and Z2 respectively, to a linker, L; and A i...	06/07/2005
6900309	Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions cont...	05/31/2005
6852746	Crystalline drug form The present invention relates to a crystalline form of 6-[(2,2-diphenylethyl)amino]-9-(N-ethyl-β-D-ribofuranosyluronamide)-N-(2-{N′-[1-(2-pyridyl)-4-piperidyl]ureido}ethyl)-9H-purine-2-carboxamide and to a process for the preparation of, compositions containing a...	02/08/2005
6740644	Chemical compounds A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3alkyl, R2	05/25/2004
6642210	2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists N-pyrazole substituted 2-adenosine compounds and methods for using the compounds as A2 A-adenosine receptor agonists useful to stimulate mammalian coronary vasodilation for therapeutic purposes and as adjuncts in cardiological imaging....	11/04/2003
6596858	Process for the production of 2-halo-6-aminopurine derivatives A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents ...	07/22/2003
6576620	Method of identifying partial adenosine A1 receptor agonists The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat ar...	06/10/2003
6576619	Orally active A1 adenosine receptor agonists Esters of N6 -oxa, thia, thioxa and azacycloalkyl substituted adenosine derivatives having the following formula; ##STR1## wherein the compounds are selective adenosine type 1 receptor agonists that are useful for the treatment cardiovascular d...	06/10/2003
6544960	Chemical compounds A compound of formula (I), wherein R2 represents C1-3 alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3 alk...	04/08/2003
6531589	Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable und...	03/11/2003
6525032	Purine derivatives The present invention relates to compounds of the class of purin-2-ylcarboxamides, useful as anti-inflammatory agents, having the formula: ##STR1## and pharmaceutically acceptable salts and solvates thereof; wherein R1 is H, C1 ...	02/25/2003
6512106	Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ...	01/28/2003
6500946	Methods for producing nucleoside derivatives and intermediates therefor Novel intermediates of nucleoside derivatives, of which the 6-position of the nucleic acid base moiety is substituted with a halogen atom, are produced. Using those novel intermediates, even substrates, of which the 3'-position of the saccharide moiety is...	12/31/2002
6498241	2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by phot...	12/24/2002
6440948	Thiophene A2A receptor agonists 2-(3-,4-(substituted)-5-alkylthienyl)adenosines and the 5'-uronic acid amide analogues thereof having the following formula: ##STR1## are disclosed herein. Additionally disclosed are medicinal methods of treatment wherein the adenosine A2A agon...	08/27/2002
6407076	Adenosine analogues and related method of treatment A compound of formula (I) wherein R2 represents C1-3 alkyl, halogen or hydrogen; R3 represents a fluorinated straight or branched alkyl group of 1-6 carbon atoms; and salts and solvates thereof, in particular, physiologica...	06/18/2002
6403567	N-pyrazole A2A adenosine receptor agonists 2-adenosine N-pyrazole compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart....	06/11/2002
6376472	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties A compound of the formula ##STR1## wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl ##STR2## where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen...	04/23/2002
6355787	Purine nucleoside modifications by palladium catalyzed methods and compounds produced This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ...	03/12/2002
6326359	Adenosine A2A receptor agonists as antiinflammatory agents The present invention provides compounds of formula (I): ##STR1## and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions containing, uses of and intermediates used in the preparation of suc...	12/04/2001
6294522	N6 heterocyclic 8-modified adenosine derivatives N6 heterocyclic 8 modified adenosine derivatives that are selective, partial or full adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating centr...	09/25/2001

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Class 536/27.62 - Nitrogen, chalcogen, or additional carbon bonded directly to the 6-position nitrogen (e.g., 6-position nitrogen is substituted, etc.)