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| Number | Title | Issue Date |
| 7544794 | Method for sequencing DNA and RNA by synthesis This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that are nucleic acid analogs. More specifically, this invention relates to compositions that allow the sequencing of oligonucleotides by synt... | 06/09/2009 |
| 7381714 | A1 adenosine receptor agonists Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists having the structure of Formula I: which are useful for treating various disease states, in particular tachycardia and atrial... | 06/03/2008 |
| 7339053 | 4′-C-substituted-2-haloadenosine derivative The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a c... | 03/04/2008 |
| 7262176 | Adenosine A receptor agonists Disclosed are novel compounds that are A3 adenosine receptor agonists, useful for treating various disease states, including cancer, cardiac ischemia, leukopenia, and neutropennia. ... | 08/28/2007 |
| 7238676 | Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and composition... | 07/03/2007 |
| 7217702 | Selective antagonists of A2A adenosine receptors Selective antagonists of A2A adenosine receptors like those of formula I are provided, wherein Y forms a ring. The novel A2A blockers are useful for the treatment of Parkinsons disease and o... | 05/15/2007 |
| 7112574 | C2,8-disubstituted adenosine derivatives and their different uses Novel C2,8-disubstituted adenosine derivatives disclosed herein have been found to be potent adenosine receptor agonists, in particular for the A2A receptor. The said compounds have biological activity against conditions such as hypertension, ischemic heart disease,... | 09/26/2006 |
| 7109180 | C-pyrazole Areceptor agonists 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart ... | 09/19/2006 |
| 7101993 | Oligonucleotides containing 2′-O-modified purines Compounds are provided containing purine nucleotides that bear moieties X at the 2′ position thereof wherein X is R1—(R2)n; R1 is C3-C20 alkyl, C4-C20 alkenyl or C2 | 09/05/2006 |
| 6949640 | Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy... | 09/27/2005 |
| 6914053 | Adenosine A3 receptor agonists Disclosed are novel adenosine A3 receptor agonists of Formula I: wherein: R is hydrogen or lower alkyl; R1 is optionally substituted lowe... | 07/05/2005 |
| 6906190 | Inhibitors for de novo-RNA polymerases and methods of identifying targets for same A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated wi... | 06/14/2005 |
| 6855817 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 02/15/2005 |
| 6855818 | C-pyrazole A2A receptor agonists 2-adenosine C-pyrazole compositions having the following formula: and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and f... | 02/15/2005 |
| 6770634 | C-pyrazole a2a receptor agonists 2-adenosine C-pyrazole compounds having formula (a) and methods for using the compounds as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart. ... | 08/03/2004 |
| 6740644 | Chemical compounds A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3alkyl, R2 | 05/25/2004 |
| 6642210 | 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists N-pyrazole substituted 2-adenosine compounds and methods for using the compounds as A2 A-adenosine receptor agonists useful to stimulate mammalian coronary vasodilation for therapeutic purposes and as adjuncts in cardiological imaging.... | 11/04/2003 |
| 6576620 | Method of identifying partial adenosine A1 receptor agonists The present invention provides a method for identifying partial adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat ar... | 06/10/2003 |
| 6525032 | Purine derivatives The present invention relates to compounds of the class of purin-2-ylcarboxamides, useful as anti-inflammatory agents, having the formula: ##STR1## and pharmaceutically acceptable salts and solvates thereof; wherein R1 is H, C1 ... | 02/25/2003 |
| 6498241 | 2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by phot... | 12/24/2002 |
| 6495528 | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.... | 12/17/2002 |
| 6403567 | N-pyrazole A2A adenosine receptor agonists 2-adenosine N-pyrazole compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.... | 06/11/2002 |
| 6355787 | Purine nucleoside modifications by palladium catalyzed methods and compounds produced This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ... | 03/12/2002 |
| 6326359 | Adenosine A2A receptor agonists as antiinflammatory agents The present invention provides compounds of formula (I): ##STR1## and pharmaceutically acceptable salts and solvates thereof, together with processes for the preparation of, compositions containing, uses of and intermediates used in the preparation of suc... | 12/04/2001 |
| 6294522 | N6 heterocyclic 8-modified adenosine derivatives N6 heterocyclic 8 modified adenosine derivatives that are selective, partial or full adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating centr... | 09/25/2001 |
| 6271212 | Prodrug azide compositions and compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the correspo... | 08/07/2001 |
| 6221851 | Pharmaceutical therapy for congestive heart failure The present invention is directed to reduce elevated levels of tumor necrosis factor-alpha (TNF-) found in a failing heart. The present invention is directed to a composition and method of regulating TNF- expression in myocardial tissue by t... | 04/24/2001 |
| 6214807 | C-pyrazole 2A A receptor agonists 2-adenosine C-pyrazole compositions having the following formula: ##STR1## and methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart.... | 04/10/2001 |
| 6166199 | N-2 substituted purines This invention presents novel purine-based compounds for inclusion into oligonucleotides. The compounds of the invention, when incorporated into oligonucleotides are especially useful as "antisense" agents--agents that are capable of specific hybridizatio... | 12/26/2000 |
| 6153744 | Nucleoside derivatives with photolabile protective groups The invention relates to nucleo-side derivatives with photo-unstable protective groups of the general formula (I) ##STR1## in which R1 is H, NO2, CN, OCH3, halogen, alkyl or alkoxyalkyl with 1 to 4 C atoms, R2 | 11/28/2000 |
| 6147200 | 2'-O-acetamido modified monomers and oligomers Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to ha... | 11/14/2000 |
| 6020483 | Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ... | 02/01/2000 |
| 5994321 | Antiviral guanine analogs A series of guanine analogs and physiological salts thereof, which are useful as virus inhibitors and as antiviral agents in the treatment of viral disease, having the basic structures of: ##STR1## wherein B is H, CH3 or NH2 ; C... | 11/30/1999 |
| 5945527 | Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide This invention discloses a method for the preparation modified nucleosides and nucleotides using a palladium catalyst, a nucleophile and carbon monoxide.... | 08/31/1999 |
| 5945524 | Process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective group and the ease of elimination from the sugar resi... | 08/31/1999 |
| 5942497 | Purine compound and catecholamine compound containing compositions and methods for administration A purine compound, which has a desired and an undesired effect when a dosage sufficient to induce the desired effect is administered to a mammal, is combined with a counteracting agent, wherein the counteracting agent can reduce the undesired effect when ... | 08/24/1999 |
| 5939543 | Stable solid 2-octynyl adenosine and process for producing the same The present invention provides two kinds of solid 2-octynyl adenosine products with novel properties which are stabilized with respect to temperature or temperature and humidity, one being solid 2-octynyl adenosine having a moisture content of not more th... | 08/17/1999 |
| 5925624 | 2,6-Di (substitutedamino) purine ribonucleoside analogues and administration to treat respiratory inflammation The present invention relates to 2,6-diaminopurine-ଲ-D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patients with ... | 07/20/1999 |
| 5830881 | L-2'3',dideoxy nucleoside analogs as anti-hepatitus B (HBV) agents The present invention relates to the surprising discovery that certain dideoxynucleoside analogs which contain a dideoxy ribofuranosyl moiety having an L-configuration (as opposed to the naturally occurring D- configuration) exhibit unexpected activity ag... | 11/03/1998 |
| 5817639 | Purine 4'-thioarabinonucleosides The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula 1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a method for preparing the purine 4'-thioarabinonucle... | 10/06/1998 |
