Class 536/27.2 - The bicyclic ring system consists of a 1,3-diazine ring, which may be hydrogenated, fused to a five-membered N-hetero ring (e.g., purine isoesters like tubercidin, toyocamycin, sangivamycin, sparsomycin A, etc.)

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein a 1,3-diazine hetero ring, which may be
No. of patents: 98
Last issue date: 01/17/2012

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Number	Title	Issue Date
8097718	3,5-disubstituted and 3,5,7-trisubstituted-3-oxazolo and 3-thiazolo[4,5-]pyrimidin-2-one compounds and prodrugs thereof The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such...	01/17/2012
7943759	3-β-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou...	05/17/2011
7560544	3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such...	07/14/2009
7432248	Nucleoside derivatives for treating Hepatitis C virus infection Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein W, W1	10/07/2008
7414031	5-nitro-nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. ...	08/19/2008
7405204	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus. ...	07/29/2008
7339054	Process for preparing branched ribonucleosides from 1,2-anhydroribofuranose intermediates A process is provided for the preparation of branched-chain ribonucleosides of formula (I): from the 1,2-anhydroderivatives of formula (II). wherein PG is a hydroxyl protecting gr...	03/04/2008
7323449	Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependen...	01/29/2008
7321033	3-B-D-ribofuranosylthiazolo [4,5-] pyrimidine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou...	01/22/2008
7244713	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, T...	07/17/2007
7217805	Bicyclonucleoside analogues Bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. Compounds of the following formula (1) or their pharmaceutically acceptable ...	05/15/2007
7217815	2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula...	05/15/2007
7202224	Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN...	04/10/2007
7202223	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, e...	04/10/2007
7192932	Use of immunomodulating agents Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described. ...	03/20/2007
7169918	Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NRR)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives Disclosed are methods and intermediates for the preparation of 7-(2′-R1-substituted-β-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infections caused by a...	01/30/2007
7163928	Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ...	01/16/2007
7157434	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, Y...	01/02/2007
7157440	Partial and full agonists of A1 adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ...	01/02/2007
7151089	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, R...	12/19/2006
7148223	4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or...	12/12/2006
7144868	Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, e...	12/05/2006
7125855	Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN...	10/24/2006
7094768	Nucleoside derivatives for treating hepatitis C virus infection Disclosed are 6-hydroxyamino- or a 6-alkoxyamino-7-deazapurine-ribofuranose derivatives, salts, pharmaceutical compositions, and methods of use thereof for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. ...	08/22/2006
7094769	2-aminocarbonyl-9H-purine derivatives The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositio...	08/22/2006
7074917	Method for purifying 5′ -protected 2′ -deoxypurine nucleosides A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a s...	07/11/2006
7071173	Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig ...	07/04/2006
7071199	Kinase inhibitors as therapeutic agents The present application is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors. ...	07/04/2006
7056895	Tirazole nucleoside analogs and methods for using same Novel heterocyclic aromatic compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an aut...	06/06/2006
6987177	Modified oligonucleotides, their preparation and their use Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as ai...	01/17/2006
6974803	Pharmaceutical combination The present invention relates to a combination comprising (a) an adenosine A2a receptor agonist as defined herein and (b) an adrenergic β2 receptor agonist, for simultaneous, sequential or separate administration by the inhaled route in the treatment of ...	12/13/2005
6914061	4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or acyl, Y is X, N3,...	07/05/2005
6900044	68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor The invention provides isolated nucleic acids molecules, designated 68999 nucleic acid molecules, which encode ubiquitin carboxyl-terminal hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containi...	05/31/2005
6887698	Glucuronyl C5-epimerase, DNA encoding the same and uses thereof The invention is directed to a novel purified mouse C5-epimerase, fragments thereof, nucleic acids encoding the same and the recombinant production thereof. The invention is also directed to fragments of such epimerase, especially N-terminal fragments that are usefu...	05/03/2005
6875597	Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules...	04/05/2005
6831069	Pyrrolo[2,3-d]pyrimidine nucleoside analogs Compositions and methods for pyrrolo[2,3-d]pyrimidine nucleoside analogs having substituents at the C4′ and C5′ positions of the ribofuranose moiety are presented. Contemplated compositions exhibit, among other things, anti-cancer and immunomodulating effects at...	12/14/2004
6800465	D-hydantoinase from Ochrobactrum anthropi The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression vectors including the nu...	10/05/2004
6777395	Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN...	08/17/2004
6753322	2-aminocarbonyl-9H-purine derivatives The present invention relates to compounds of the formula: and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions conta...	06/22/2004
6720168	2,5-DKG permeases The invention provides isolated nucleic acid molecules encoding polypeptides having 2,5-DKG permease activity, and oligonucleotides therefrom. The isolated nucleic acid molecules can be expressed in appropriate bacterial cells to enhance the production of 2-KLG, whi...	04/13/2004

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Class 536/27.2 - The bicyclic ring system consists of a 1,3-diazine ring, which may be hydrogenated, fused to a five-membered N-hetero ring (e.g., purine isoesters like tubercidin, toyocamycin, sangivamycin, sparsomycin A, etc.)