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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 7439350 | Nucleotide analogs Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed i... | 10/21/2008 |
| 7439351 | 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents Method for the sterospecific preparation of 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentafuranonucleoside compounds. 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentofuranonucleoside compounds are also described. Finally, the invention concerns the use of th... | 10/21/2008 |
| 7368565 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, withou... | 05/06/2008 |
| 7339053 | 4′-C-substituted-2-haloadenosine derivative The present invention provides a 4′-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, R1 represents an ethynyl group or a c... | 03/04/2008 |
| 7335470 | Compilations of nucleic acids and arrays and methods of using them In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or p... | 02/26/2008 |
| 7276364 | Nucleic acids encoding endotheliases, endotheliases and uses thereof Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease dom... | 10/02/2007 |
| 7235647 | Intermediate and process for preparing of β- anomer enriched 21-deoxy,21,21-difluoro-D-ribofuranosyl nucleosides The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically accept... | 06/26/2007 |
| 7198893 | DNA diagnostics based on mass spectrometry Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromo... | 04/03/2007 |
| 7192729 | Methods for assaying homocysteine The present invention relates to compositions and methods for assaying homocysteine (Hcy) and thus related moieties, e.g., S-adenosylhomocysteine (SAH) or adenosine. More particularly, assay methods that employ, mutant SAH hydrolase having binding affinity for Hcy, ... | 03/20/2007 |
| 7192932 | Use of immunomodulating agents Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described. ... | 03/20/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7172892 | Nucleic acid molecules encoding serine protease CVSP14, the encoded polypeptides and methods based thereon Provided herein are polypeptides designated CVSP14 polypeptides that exhibit protease activity as a single chain or as an activated two chain form. Methods using the polypeptides to identify compounds that modulate the protease activity thereof are provided. The pol... | 02/06/2007 |
| 7166702 | Cytotoxic conjugates comprising a chemokine receptor targeting agent Conjugates containing as a ligand chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune... | 01/23/2007 |
| 7157418 | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders Conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immu... | 01/02/2007 |
| 7125703 | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon Provided herein are type II transmembrane serine protease 7 (MTSP7) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds t... | 10/24/2006 |
| 7112430 | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon Provided herein are type II transmembrane serine protease 10 (MTSP10) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds... | 09/26/2006 |
| 7105333 | Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds t... | 09/12/2006 |
| 7081192 | Methods for manipulating moieties in microfluidic systems This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated ... | 07/25/2006 |
| 7071173 | Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig ... | 07/04/2006 |
| 7064112 | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist Adenosine receptor agonists, particularly an agonist which binds to the A3 adenosine receptor, are used for induction of production or secretion of G-CSF within the body, prevention or treatment of toxic side effects of a drug or prevention or treatment of leukopeni... | 06/20/2006 |
| 7019128 | Propargylethoxyamino nucleotides Propargylethoxyamino nucleosides are disclosed having the structure wherein R1 and R2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is ... | 03/28/2006 |
| 6995259 | Method for the chemical synthesis of oligonucleotides The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof. ... | 02/07/2006 |
| 6974802 | Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine A method of treating HBV or HIV infections comprising administering to an individual an effective amount of the compound of formula IId′: wherein R2 is the residue of an aliphatic ... | 12/13/2005 |
| 6962991 | Process for the synthesis of pyrazolopyrimidines The present invention provides a nucleoside comprising a pyrazolopyrimidine base and a process for producing the same. In particular, the processes of the present invention comprises using a halogenated pyrazolopyrimidine base and removing the halogen after the base... | 11/08/2005 |
| 6960568 | Nucleosides and related processes, pharmaceutical compositions and methods The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention ... | 11/01/2005 |
| 6949521 | Therapeutic azide compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs... | 09/27/2005 |
| 6924271 | 3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou... | 08/02/2005 |
| 6919320 | Pharmaceutical compositions containing deoxyribonucleosides for wound healing The invention relates to compositions comprising 2′-deoxyribonucleosides. The invention also relates to methods of accelerating the healing of wounds, abrasions, cuts, incisions, and superficial burns induced by heat, sunlight, chemical agents, or infections, and ... | 07/19/2005 |
| 6897302 | Method for synthesizing β-L-5-fluoro-2′,3′-dideoxy-2′,3′-didehydrocytidine (β-L-FD4C) The invention provides a method of synthesizing β-L-5-fluoro-2′,3′-dideoxy-2′,3′-didehydrocytidine (β-L-FD4C). The method allows for large-scale production of β-L-FD4C in an efficient, cost-effective, and environmentally sound manner. ... | 05/24/2005 |
| 6822089 | Preparation of deoxynucleosides Methods for preparing deoxynucleosides from their corresponding ribonucleosides by forming 3-tert-butylphenoxythiocarbonylderivatives of the ribonucleosides and subsequently effecting radical deoxygenation reactions at the carbon atoms to be deoxygenated. ... | 11/23/2004 |
| 6743910 | Stereoselective synthesis of nucleoside analogues The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of β and α anomers represented by the following formula A or formula B: wherein R is selected from the... | 06/01/2004 |
| 6596858 | Process for the production of 2-halo-6-aminopurine derivatives A novel process for preparing 2-halo-6-aminopurine derivatives and their analogs is disclosed. The method comprises halogenation of 2,6-diaminopurine derivatives at the C-2 position in a specific combination of aprotic polar and nonpolar organic solvents ... | 07/22/2003 |
| 6579976 | Process for producing 2',3'-diethyl substituted nucleoside derivatives There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or... | 06/17/2003 |
| 6573247 | Anti-viral pyrimidine nucleoside analogues A compound having formula (I), wherein R is selected from the group comprising C5 to C20 alkyl, C5 to C20 cycloalkyl, halogens, aryl and alkylaryl; R' is selected from the group comprising hydrogen, alkyl, cyclo... | 06/03/2003 |
| 6555676 | Biologically active phosphotriester-type compounds Compounds of formula RS--P(.dbd.O)(QR)--Nu where: R is a radical --(CH2)n--W--X; X is a radical --C(.dbd.Z)(Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted wi... | 04/29/2003 |
| 6541625 | Stereoselective synthesis of nucleoside analogues The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of ଲ and anomers represented by the following formula A or formula B: ##STR1## wherein R is selected from the group consistin... | 04/01/2003 |
| 6525033 | Nucleosides with anti-hepatitis B virus activity A method for treating HBV infections via administration of 2', 3' dideoxynucleoside compounds.... | 02/25/2003 |
| 6500946 | Methods for producing nucleoside derivatives and intermediates therefor Novel intermediates of nucleoside derivatives, of which the 6-position of the nucleic acid base moiety is substituted with a halogen atom, are produced. Using those novel intermediates, even substrates, of which the 3'-position of the saccharide moiety is... | 12/31/2002 |
| 6479463 | Purine L-nucleosides, analogs and uses thereof Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositi... | 11/12/2002 |
| 6458772 | Prodrugs Compounds of the formula I ##STR1## or corresponding monohydroxynucleoside derivatives wherein: R1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon; a C4 -C22 saturated or unsaturated, optionally ... | 10/01/2002 |
