Famous Patents
In 1608, Dutch eyeglass maker Hans Lipperhey filed the first patent for a working telescope. The patent was denied.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8153781 | Dendrimer conjugates of agonists and antagonists of the GPCR superfamily Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A1 aden... | 04/10/2012 |
| 8114986 | Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either single or double and wherein R1, R2, R3, R4 or R5, equal or differen... | 02/14/2012 |
| 7897759 | Metabolically stable puromycin analogs Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure further relates to pharmaceutical compositions comprising one or more dis... | 03/01/2011 |
| 7863438 | Stable salt of 3′-phosphoadenosine 5′-phosphosulfate The present invention provides a stable salt of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) and a production method therefor. The present invention is directed to a stable salt of PAPS (amine salt), which is formed between PAPS and an amine compound, and... | 01/04/2011 |
| 7563887 | Universal nucleobase analogs This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that can bind to nucleic acids, including compositions and processes that by doing so have use in the capture, detection and sequencing of nuc... | 07/21/2009 |
| 7563886 | Nucleoside releasing functional unit through oxidation and process for producing oligonucleotide containing thereof A method of easily releasing a useful substance bonded to oligonucleotide without impairing a target nucleic acid; and a novel base therefore. A nucleoside of nucleotide (oligonucleotide containing thereof) represented by the formula (I) | 07/21/2009 |
| 7429571 | Therapeutic furopyrimidines and thienopyrimidines The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and ... | 09/30/2008 |
| 7419963 | Indole antiviral compositions and methods The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as... | 09/02/2008 |
| 7399754 | N-quinoline or isoquinoline substituted purine derivatives Novel compound having the following formula: wherein W represents a hydrogen, an optionally substituted C1-6 alkyl, an optionally substituted C3-6 cycloalkyl, or an optionally substituted C1-6 | 07/15/2008 |
| 7393954 | Process for the production of pentostatin aglycone and pentostatin A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates. ... | 07/01/2008 |
| 7368437 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents Methods and compounds for inhibiting the enzymes adenosine monophosphate deaminase or adenoside deaminase are provided. Such methods and compounds are useful in agriculture, horticulture and/or pharmacology as, for example, active compounds for crop protection or ph... | 05/06/2008 |
| 7321033 | 3-B-D-ribofuranosylthiazolo [4,5-] pyrimidine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou... | 01/22/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7282581 | Oligonucleotide labeling reactants based on acyclonucleosides and conjugates derived thereof The invention relates to a labeling reactant of formula (I) useful for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid support tethered to Z... | 10/16/2007 |
| 7273933 | Methods for synthesis of oligonucleotides Improved methods for synthesis of oligonucleotides and other phosphorus-linked oligomers are disclosed. The methods include the use of aromatic solvents, alkyl aromatic solvents, halogenated aromatic solvents, halogenated alkyl aromatic solvents, or aromatic ether s... | 09/25/2007 |
| 7227017 | Process for the preparation of phosphorothioate oligonucleotides A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitril... | 06/05/2007 |
| 7217815 | 2-beta -modified-6-substituted adenosine analogs and their use as antiviral agents Various 2′-beta-methyl-6-substituted adenosine analogs (including 2,6-disubstituted adenosine, 8-aza-6-substituted adenosine, and 2-aza-6-substituted adenosine) are prepared by conventional and combinatorial library approaches. Contemplated compounds are particula... | 05/15/2007 |
| 7202224 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN... | 04/10/2007 |
| 7202223 | Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, e... | 04/10/2007 |
| 7192932 | Use of immunomodulating agents Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described. ... | 03/20/2007 |
| 7169916 | Chloral-free DCA in oligonucleotide synthesis A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chlora... | 01/30/2007 |
| 7163928 | Partial and full agonists of Aadenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ... | 01/16/2007 |
| 7157440 | Partial and full agonists of A1 adenosine receptors Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction. ... | 01/02/2007 |
| 7144868 | Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such compounds are represented by Formula I as follows: wherein, e... | 12/05/2006 |
| 7125855 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN... | 10/24/2006 |
| 7101994 | Process for preparing substituted benzimidazole compounds The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity. ... | 09/05/2006 |
| 7074917 | Method for purifying 5′ -protected 2′ -deoxypurine nucleosides A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a s... | 07/11/2006 |
| 7071199 | Kinase inhibitors as therapeutic agents The present application is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors. ... | 07/04/2006 |
| 7071173 | Antiviral methods employing double esters of 2′, 3′-dideoxy-3′-fluoroguanosine A method for treatment of HBV and HIV infections comprising administering the compound or salt of formula Ig ... | 07/04/2006 |
| 7045309 | 9-substituted adenine derivatives as prodrug regulators of cell and tissue function The present invention relates to 9-substituted adenine derivatives represented by formula (I) wherein W is selected from the group consisting of H, halogen, azido and amino group; X is selected from the group consistin... | 05/16/2006 |
| 7019135 | Anti-viral pyrimidine nucleoside analogues Compounds of the general formula (I) are described wherein R, R′, R″, Q, T, T′, T″, T″′, W, X, and Z are as defined in the specification. Compounds according to the invention preferably display potent anti-... | 03/28/2006 |
| 7002006 | Protection of nucleosides A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally su... | 02/21/2006 |
| 6974803 | Pharmaceutical combination The present invention relates to a combination comprising (a) an adenosine A2a receptor agonist as defined herein and (b) an adrenergic β2 receptor agonist, for simultaneous, sequential or separate administration by the inhaled route in the treatment of ... | 12/13/2005 |
| 6958214 | Polymorphic kinase anchor proteins and nucleic acids encoding the same Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herei... | 10/25/2005 |
| 6949640 | Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy... | 09/27/2005 |
| 6949639 | Oligonucleotide labeling reactants and their use The invention relates to a novel labeling reactant of formula (I) suitable for labeling an oligonucleotide wherein: R is a temporary protecting group. A is either a phosphorylating moiety or a solid support t... | 09/27/2005 |
| 6924271 | 3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou... | 08/02/2005 |
| 6914148 | Guanidinium functionalized intermediates The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic,... | 07/05/2005 |
| 6794502 | Methods for removing dimethoxytrityl groups from oligonucleotides The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. Th... | 09/21/2004 |
| 6777395 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN... | 08/17/2004 |
