Class 536/27.12 - Separation or purification (e.g., resolving isomeric mixtures, etc.)

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Processes for the separation, isolation, or purification
No. of patents: 35
Last issue date: 07/24/2007

Number	Title	Issue Date
7247721	Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m...	07/24/2007
7153840	Aqueous fludarabine phosphate composition This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which comprises fludarabine phosphate, a base, and water. The concentration o...	12/26/2006
7148207	Oral fludara of high-purity formulation with quick release of active ingredient This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants. ...	12/12/2006
7022835	Method for binding nucleic acids to a solid phase The invention concerns a method for binding nucleic acids to a solid phase in which a nucleic acid containing solution is contacted with a solid phase which has hydrophobic and hydrophilic groups on its surface or/and which comprises a hydrophilic, water-containing ...	04/04/2006
7001724	Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases The invention provides compositions and methods for releasing and for isolating nucleic acids from biological samples, preferably from whole tissue, using cationic surfactants and proteases. The surfactant-protease combinations, when used with whole tissue, macerate...	02/21/2006
6855817	Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m...	02/15/2005
6762027	Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases The invention relates to compositions and methods for isolating nucleic acids from biological samples, including whole tissue. The invention also provides kits for isolating nucleic acids from biological samples. ...	07/13/2004
6579976	Process for producing 2',3'-diethyl substituted nucleoside derivatives There can be provided an excellent industrial process for producing compounds having sugar-moiety hydroxyl groups or halogen atoms reduced in nucleic acids or in derivatives thereof by allowing O-thiocarbonyl derivatives of sugar-moiety hydroxyl groups or...	06/17/2003
6559299	Preparation and isolation of indolocarbazole glycosides The present invention relates to a novel process to make indolocarbazole glycosides in high purity which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like....	05/06/2003
6555677	Phase transfer catalyzed glycosidation of an indolocarbazole The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, an...	04/29/2003
6414137	Selective solvent extraction for the purification of protected nucleosides A process for the purification of nucleosides, and more particularly to a selective solvent extraction method for purifying protected nucleosides. In the purification process, solid particles of protected nucleosides are selectively washed to remove undes...	07/02/2002
6066720	Modified oligonucleotides, their preparation and their use The invention relates to novel modified oligonucleotides which contain at least one 8-azapurine base and form more stable hybridization complexes with nucleic acids; To a process for their preparation, and to their use as inhibitors of gene expression, as...	05/23/2000
6054442	Methods and compositions for modulation and inhibition of telomerase in vitro It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as 7-deaza-2'-deoxyquanosine-5'-triphosphate (7-deaza-dGTP) were found ...	04/25/2000
6046322	Process for the production of fludarabine-phosphate lithium, sodium, potassium, calcium and magnesium salts and purification process for the production of fludarabine-phosphate and fludarabine-phosphate with a purity of at least 99.5% A reduced temperature crystallization process for the obtaining fludarabine phosphate at a purity of at least 99.5%....	04/04/2000
5801237	Method for the purification of short nucleic acids Method for the purification of a synthetic oligonucleotide from failure sequences comprising contacting a sample containing the desired oligonucleotide in protected water-soluble form with a hydrophilic adsorbent exhibiting anion exchange groups under con...	09/01/1998
5783688	Purification of 3'-FDDU and resultant compositions 2',3'-Dideoxy-3'-fluorouridine is purified by treating an aqueous or aqueous methanolic solution with charcoal....	07/21/1998
5621084	Process for removal of allyl group or allyloxycarbonyl group This invention relates to a process for the removal of an allyl or allyloxycarbonyl group from an allyl or allyloxycarbonyl group protected compound (such as an allylic ester, carbonate, carbamate, O-allyl derivatives or N-allyl derivatives), which compri...	04/15/1997
5606048	Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides A stereoselective glycosylation process for preparing beta- and alpha-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides by reacting a concentrated alpha- or beta-anomer enriched 2 -deoxy-2,2-difluorocarbohydrate or 2-deo...	02/25/1997
5451671	Method of purifying 2',3'-dideoxynucleosides A crude 2',3'-dideoxynucleoside compound is purified by extracting with an organic solvent, or crystallizing, the 2',3'-dideoxynucleoside compound from a basic aqueous solution having a pH of not less than 12 containing the same. In another embodiment of ...	09/19/1995
5395928	Chromatographic separation of phosphorothioate oligonucleotides A method is provided for the preparation and/or analysis of synthetic phosphorothioate and -dithioate oligonucleotides. In particular, the method permits separation of fully sulfurized phosphorothioate or -dithioate oligonucleotides from incompletely sulf...	03/07/1995
5371210	Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides A stereoselective fusion glycosylation process for preparing beta-anomer enriched 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides is provided which requires reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-...	12/06/1994
5262531	Process for preparing 2'-deoxy-ଲ-adenosine 2'-deoxy-ଲ-adenosine can be industrially and easily obtained without using expensive or dangerous materials by the process of the present invention, which comprises the steps of: preparing a salt of adenine from adenine, allowing to condense the sal...	11/16/1993
5183885	Method for chromatographic separation of synthetic phosphorothioate oligonucleotides A method is provided for the preparation and/or analysis or synthetic phosphorothioate and -dithioate oligonucleotides. In particular, the method permits separation of fully sulfurized phosphorothioate or -dithioate oligonucleotides from incompletely sulf...	02/02/1993
4962193	Process for purifying 2',3'-dideoxynucleosides A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent....	10/09/1990
4954623	Recovery of difluoro sugar A process for recycling the difluoro sugar in the synthesis of 2,2-difluoronucleosides proceeds by removing the base moiety of ଱-difluoronucleosides by reduction and hydrolysis, followed by oxidation to put the difluro sugar in a form conventiently ...	09/04/1990
4691012	Sialic acid derivative and process for preparing the same A novel N-acetylneuraminic acid derivative, represented by the general formula: ##STR1## wherein the R1 groups are, independently, hydrogen or acetyl; R2 is a nucleoside residue; and R3 is carboxyl or methoxycarbonyl....	09/01/1987
4581166	Method for isolating and purifying antibiotics A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0° to 40° C. and at a pressure which lies between the critical pressure and ...	04/08/1986
4577012	Method of separation of nucleotides and nucleosides from each other The industrially favored separation of nucleotides and nucleosides from a solution containing both of them can be conducted by contacting said solution, after adjusted to a pH of not higher than 7, with activated carbon to adsorb the nucleosides and nucle...	03/18/1986
4552954	Concentrating nikkomicin mixtures A process for concentrating nikkomicins (X) and (Z) from a dilute impure aqueous solution thereof, comprising contacting the solution with a weakly basic ion exchanger and eluting the adsorbed material with an acid thereby to obtain a concentrated mixture...	11/12/1985
4524145	4'-Deschlororebeccamycin pharmaceutical composition and method of use A new antitumor antibiotic designated herein as 4'-deschlororebeccamycin is produced by fermentation of Nocardia aerocolonigenes ATCC 39243. The new compound possesses antibacterial activity and inhibits the growth of tumors in experimental animals....	06/18/1985
4455420	4-Amino-7-(5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d] pyrimidine A compound, 4-Amino-7-(5-deoxy-beta-D-ribofuranosyl)-5-iodo-7H-pyrrolo[2,3-d] pyrimidine, as well as process to produce this compound, are disclosed. The compound is useful as a muscle relaxant....	06/19/1984
4374981	Ultrafiltration of fermentation broth containing nucleosides to separate inosine and guanosine from the broth Inosine and/or guanosine can be separated from fermentation broth containing microbial cells and high-molecular-weight substances by heat-treating said broth at 90° to 110° C., followed by subjecting to ultrafiltration. The present process is advantageo...	02/22/1983
4195176	Imidazole compounds, methods for their production and conversion of said compounds into (R)-3-(2-deoxy-ଲ-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidaz ol[4,5-d][1,3]diazepin-8-ol 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihydroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-addition salts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared by catalytically reducing a...	03/25/1980
4151347	Separation of coformycin and its related nucleosides A known nucleoside, coformycin and its related substances such as isocoformycin, 2'-deoxycoformycin and formycins present as a mixture of them may be separated from each other when an aqueous solution containing them is chromatographed on a column of a ca...	04/24/1979
4078139	Process for deoxygenating secondary alcohols The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group selected from the ...	03/07/1978

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Class 536/27.12 - Separation or purification (e.g., resolving isomeric mixtures, etc.)