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| Number | Title | Issue Date |
| 7667034 | Chemical synthesis of with enrichment of ()- This invention relates to an improved process for the industrial manufacture of S-adenosyl-L-methionine (SAMe) of formula (I), which consists of stereo-selective methylation of S-adenosyl-L-homocysteine (SAH) with the enrichment of active (S,S)-isomer. ... | 02/23/2010 |
| 7368437 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents Methods and compounds for inhibiting the enzymes adenosine monophosphate deaminase or adenoside deaminase are provided. Such methods and compounds are useful in agriculture, horticulture and/or pharmacology as, for example, active compounds for crop protection or ph... | 05/06/2008 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7227017 | Process for the preparation of phosphorothioate oligonucleotides A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitril... | 06/05/2007 |
| 7176305 | Production method for purine nucleotide derivative disodium crystals and alcohol removing method Purine nucleotide derivative disodium crystals having a minimized amount of remaining alcohol such as methanol, ethanol or a mixture thereof are produced by overdrying purine nucleotide derivative disodium crystals containing the alcohol; and bringing the overdried ... | 02/13/2007 |
| 7153840 | Aqueous fludarabine phosphate composition This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which comprises fludarabine phosphate, a base, and water. The concentration o... | 12/26/2006 |
| 7148207 | Oral fludara of high-purity formulation with quick release of active ingredient This invention relates to a quick-release tablet formulation with >99.19% pure fludara (high-purity fludara) as an active ingredient in a defined composition of residual contaminants. ... | 12/12/2006 |
| 7125982 | Microbial production of nuclease resistant DNA, RNA, and oligo mixtures The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of both RNA and DNA forming stable phosphorothioate internucleotide link... | 10/24/2006 |
| 7019128 | Propargylethoxyamino nucleotides Propargylethoxyamino nucleosides are disclosed having the structure wherein R1 and R2 are —H, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is ... | 03/28/2006 |
| 6949640 | Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy... | 09/27/2005 |
| 6949521 | Therapeutic azide compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs... | 09/27/2005 |
| 6900309 | Purine derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, and to processes for the preparation of, intermediates used in the preparation of, compositions cont... | 05/31/2005 |
| 6884880 | Process for the preparation of 9-β-anomeric nucleoside analogs A process for substantially enhancing the regio and stereoselective synthesis of 9-β-anomeric nucleoside analogs is described. The introduction of the sugar moiety onto a 6-substituted purine base was preformed so that only the 9-β-D- or L-purine nucleoside analog... | 04/26/2005 |
| 6812342 | Esters of cyclic ADP ribose derivatives The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention is the composition of one or more hydrophobic derivatives of cyclic ... | 11/02/2004 |
| 6794142 | Amplification using modified primers The present invention provides modified primers for use in the amplification of a nucleic acid sequence. Amplifications carried out using the modified primers result in less template-independent non-specific product (primer dimer) compared to amplifications carried ... | 09/21/2004 |
| 6610841 | Nucleotide-based prodrugs This invention relates to nucleotide-based prodrugs and their drug-delivery applications. The nucleotide-based prodrugs of the present invention comprise a drug component covalently attached via junctional ester bond(s) to one or more nucleotide component... | 08/26/2003 |
| 6555676 | Biologically active phosphotriester-type compounds Compounds of formula RS--P(.dbd.O)(QR)--Nu where: R is a radical --(CH2)n--W--X; X is a radical --C(.dbd.Z)(Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted wi... | 04/29/2003 |
| 6531589 | Base protecting groups and synthons for oligonucleotide synthesis The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable und... | 03/11/2003 |
| 6512106 | Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to ... | 01/28/2003 |
| 6506896 | Use of a pentopyranosyl nucleoside for producing an electronic component, and conjugates of said pentopyranosyl nucleoside The invention relates to a pentopyranosylnucleoside of the formula (I) or of the formula (II) ##STR1## their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.... | 01/14/2003 |
| 6420546 | Oligoribonucleotide and ribozyme analogs with terminal 3'--3' and/or 5'--5' linkages The invention relates to oligoribonucleotide analogs with terminal 3'--3' and/or 5'--5' internucleotide linkages. This modification stabilizes the molecules altered in this way, including ribozymes, without adversely altering their properties, including, ... | 07/16/2002 |
| 6407223 | Process for the synthesis of modified P-chiral nucleotide analogues The process of the instant invention is drawn to the synthesis of modified P-chiral nucleotide analogues in the form of pure diastereomers possessing preselected configuration at the P-atom. Oligonucleotides prepared by the method of the invention contain... | 06/18/2002 |
| 6399589 | Biologically active phosphotriester-type compounds Compounds of formula RS--P(.dbd.O)(QR)--Nu where: R is a radical --(CH2)n--W--X; X is a radical --C(.dbd.Z) (Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted w... | 06/04/2002 |
| 6329519 | Intermediates for oligonucleotide synthesis A compound of formula (I) wherein B1 is a radical of a nucleoside base, R1 is hydrogen or a hydroxy-protecting group, R2 is hydrogen, hydroxy or a 2'-nucleoside-modifying atom or group, R3 is an unsubstituted or... | 12/11/2001 |
| 6320035 | C-nucleoside derivatives and their use in the detection of nucleic acids The invention concerns pyrrolo-[3,2-d]pyrimidine, pyrazolo-[4,3-d]pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V ##STR1## or appropriate derivatives as well as processes for their production.... | 11/20/2001 |
| 6252060 | Antiviral liponucleosides: treatment of hepatitis B Compounds for treating hepatitis B infections. The compounds consist of nucleoside analogues having anti-hepatitis B activity which are linked, commonly through a 5' phosphate of the pentose residue, to one of a selected group of lipids. The lipophilic na... | 06/26/2001 |
| 6232465 | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydrox... | 05/15/2001 |
| 6200757 | Method for controlling the extension of an oligonucleotide The present invention relates to a method for selectively extending an oligonucleotide primer along a specific target polynucleotide sequence in a mixture of polynucleotides. A combination is provided comprising the mixture, an oligonucleotide primer havi... | 03/13/2001 |
| 6174998 | C-nucleoside derivatives and their use in the detection of nucleic acids The invention concerns pyrrolo-[3,2-d]pyrimidine, pyrazolo-[4,3-d]pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V ##STR1## or appropriate derivatives as well as processes for their production. The compou... | 01/16/2001 |
| 6147205 | Photocleavable protecting groups and methods for their use Novel compounds are provided which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be remo... | 11/14/2000 |
| 6140310 | Phosphorous prodrugs The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells a... | 10/31/2000 |
| 6133438 | Process for the preparation of 2'-O-alkyl purine phosphoramidites Processes for preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramidites include the steps of alkylating nucleoside precursors, adding suitable blocking groups and phosphitylating. For the guanosine 2'-O-alkylated 3... | 10/17/2000 |
| 6124445 | Phosphotriester oligonucleotides, amidities and method of preparation Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes, particularly carboxyesterases, to provide the unprotected oligon... | 09/26/2000 |
| 6111086 | Orthoester protecting groups Novel orthoesters are provided which can be used as a 2'-hydroxyl protecting groups or 2'-modification in the synthesis of polymers containing ribonucleic acid (RNA) nucleotides. The RNA comprising the orthoester can be handled and analyzed while 2'-modif... | 08/29/2000 |
| 6066722 | Inhibitors of nucleoside metabolism The present invention provides compounds having the formula: ##STR1## wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3 ; R is an optionally substitut... | 05/23/2000 |
| 6048975 | Process for the chemical synthesis of oligonucleotides A process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective g... | 04/11/2000 |
| 6046322 | Process for the production of fludarabine-phosphate lithium, sodium, potassium, calcium and magnesium salts and purification process for the production of fludarabine-phosphate and fludarabine-phosphate with a purity of at least 99.5% A reduced temperature crystallization process for the obtaining fludarabine phosphate at a purity of at least 99.5%.... | 04/04/2000 |
| 6020482 | Phosphotriester type biologically active compounds Phosphotriester compound of general formula (I); ##STR1## wherein R is a radical --(CH2)n --S--X in which X is a radical (a) or --S--U, Z being O or S, and Y and U denote an alkyl, aryl or osidic radical, optionally substituted ... | 02/01/2000 |
| 6001611 | Modified nucleic acid amplification primers The present invention provides modified primers for use in the amplification of a nucleic acid sequence. Amplifications carried out using the modified primers result in less non-specific amplification product, in particular, primer dimer, and a concomitan... | 12/14/1999 |
| 5990303 | Synthesis of 7-deaza-2'deoxyguanosine nucleotides The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO3 H2, --P2 O6 H3 or --P3 O9 H4 residue o... | 11/23/1999 |
