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| Number | Title | Issue Date |
| 8153780 | Reporter unit for detection of target molecules using polymerisable substrate The invention relates to a reporter unit for detecting a target molecule comprising at least one component attached to a target molecule specific probe, wherein said at least one component is liberated from said probe by the activity of a first enzyme thereby making... | 04/10/2012 |
| 8148516 | Flowcell systems for single molecule detection The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In opera... | 04/03/2012 |
| 8067581 | Biomolecules having multiple attachment moieties for binding to a substrate surface Compounds relating to attachment chemistries for binding biomolecules to a substrate surface are described. These include compounds of the following structure: The biomolecule includes a single nucleic acid, oligonucleotide... | 11/29/2011 |
| 8063200 | Labeled compound and detection method using the same A labeled compound is so designed that an aromatic tertiary amine compound is bondable with a biomolecule. One of S1 and S2 contains a group bound with a molecular chain 10 (e.g. an oligonucleotide) capable of binding with a biomolecule or a re... | 11/22/2011 |
| 7968702 | Labeled reactants and their uses Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions, that include structural components that maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging eff... | 06/28/2011 |
| 7960543 | Nucleoside or nucleotide derivative and use thereof The object of the present invention is to provide a nucleoside or nucleotide having a 5-substituted-2-oxo(1H)pyridin-3-yl group as a base, as well as a method using the same. In one embodiment, the nucleoside or nucleotide of the present invention has a fluor... | 06/14/2011 |
| 7825237 | Oligonucleotides and analogs labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a dono... | 11/02/2010 |
| 7803936 | Compounds and methods for labeling oligonucleotides The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of... | 09/28/2010 |
| 7795424 | Labelled nucleotides The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterized in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group ... | 09/14/2010 |
| 7767805 | Methods and compositions for sequencing a nucleic acid The invention provides nucleotide analogs and methods of using them in sequencing reactions. ... | 08/03/2010 |
| 7745614 | Universal linker compositions for the release or transfer of chemical agents from a polynucleotide A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucle... | 06/29/2010 |
| 7645872 | Compounds and methods for labeling oligonucleotides The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of... | 01/12/2010 |
| 7553959 | Fluorescent dye composition and target labeled therewith This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful ... | 06/30/2009 |
| 7514551 | Multisignal labeling reagents, and processes and uses therefor The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in detecting or amplifying analyte-specific moieties. ... | 04/07/2009 |
| 7504496 | Water-soluble rhodamine dye conjugates The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and ... | 03/17/2009 |
| 7504495 | Quencher compositions comprising anthraquinone moieties The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucle... | 03/17/2009 |
| 7482444 | Terminating substrates for DNA polymerases This invention concerns novel terminating substrates for DNA polymerases. The substrates are nucleoside triphosphates labeled with lanthanide chelates. ... | 01/27/2009 |
| 7476735 | Compounds and methods for labeling oligonucleotides The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of... | 01/13/2009 |
| 7442529 | Fluorescent probes for biological studies The present invention provides fluorescent compounds of formula (I) and methods monitoring protein-protein interactions. ... | 10/28/2008 |
| 7435603 | Labeling proteins with dyes that are insoluble or only sparingly soluble in water The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the... | 10/14/2008 |
| 7432058 | Methods of labeling nucleic acids with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 10/07/2008 |
| 7427673 | Labelled nucleotides Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. ... | 09/23/2008 |
| 7423140 | Oligonucleotides and analogs labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a dono... | 09/09/2008 |
| 7423143 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 09/09/2008 |
| 7419965 | Nucleotide lipid ester derivatives The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formula wherein R1, R2, R3, X and Y are defined as described herein and salts thereof... | 09/02/2008 |
| 7414116 | Labelled nucleotides The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) wherein X is selected from the group c... | 08/19/2008 |
| 7414117 | Nucleotide derivative and DNA microarray A novel nucleotide derivative, in case of existing as a member of a single-stranded sequence, undergoing a change in the fluorescent signal intendity depending on the corresponding base type in the partner strand with which the single-stranded sequence is hybridized... | 08/19/2008 |
| 7414118 | Modified oligonucleotides and applications thereof Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof. ... | 08/19/2008 |
| 7408051 | Modified oligonucleotides and applications thereof Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof. ... | 08/05/2008 |
| 7407747 | Method for drying dye-terminator sequencing reagents A dry composition comprising a nucleotide linked to a fluorescent dye is provided. A method of making a dry composition comprising the step of drying a solution comprising a nucleotide linked to a fluorescent dye is provided. A method is provided for performing a re... | 08/05/2008 |
| 7405281 | Fluorescent nucleotide analogs and uses therefor Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single bas... | 07/29/2008 |
| 7402671 | UV excitable fluorescent energy transfer dyes Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 07/22/2008 |
| 7402677 | Fluorescent through-bond energy transfer cassettes based on xanthine and pyronin derivatives A TBET cassette including at least one xanthine- or pyronin-based compound as a donor or acceptor is disclosed. Also, a method of TBET cassette design in which four criteria may be used is provided. TBET cassettes may be used to label biological molecules, in clothi... | 07/22/2008 |
| 7399614 | 5-methylcytosine detection, compositions and methods therefor Compositions and methods for detecting 5-methylcytosine in a nucleic acid are disclosed. A 5-methylcytosine discriminator, which is a deoxyribonucleosidetriphosphate comprising a cytosine-pairing moiety such as a guanosine and a moiety which hinders hydrogen bonding... | 07/15/2008 |
| 7399846 | Libraries of oligomers labeled with different tags A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support,... | 07/15/2008 |
| 7399854 | Regents labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 07/15/2008 |
| 7388092 | Oligonucleotides and analogs labeled with energy transfer dyes Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 06/17/2008 |
| 7385050 | Cleavable linker for polynucleotide synthesis Functionalized supports for polynucleotide synthesis are disclosed. The supports have linker moieties that are stable to conditions used in polynucleotide synthesis, but may be cleaved to release synthesized polynucleotides from the support. Methods of making the fu... | 06/10/2008 |
| 7384746 | Charge tags and the separation of nucleic acid molecules The present invention relates to novel phosphoramidites, including positive and neutrally charged compounds. The present invention also provides charge tags for attachment to materials including solid supports and nucleic acids, wherein the charge tags increase or d... | 06/10/2008 |
| 7378517 | UV excitable energy transfer reagents Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 05/27/2008 |
