Class 536/26.44 - Cobalamin analogs (i.e., compounds wherein the benzimidazole ring system has been replaced by another organic ring structure, or compounds wherein cobalt has been removed or replaced by another metal, or is substituted by a group other than -OH or -CN)

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which are cobalamin analogs, e.g., compounds wherein
No. of patents: 26
Last issue date: 02/20/2007

Number	Title	Issue Date
7179445	Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ...	02/20/2007
7141233	Radionuclide labeling of vitamin Band coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin,	11/28/2006
6905884	Fluorescent cobalamins and uses thereof The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalam...	06/14/2005
6806363	Cobalamin conjugates useful as antitumor agents The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical compositions comprising the compounds, and methods for using the compound...	10/19/2004
6797521	Fluorescent cobalamins and uses thereof The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalam...	09/28/2004
6613305	Radionuclide labeling of vitamin B12 and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating gro...	09/02/2003
6262253	Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion...	07/17/2001
6211355	Radionuclide labeling of vitamin B12 and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating gro...	04/03/2001
6096290	Radionuclide labeling of vitamin B₁₂ and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobaltmin, Y is a linking group and X is ...	08/01/2000
6004533	Radionuclide labeling of vitamin B₁₂ and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is ...	12/21/1999
5936082	Metallocorrinoids as biologically compatible carriers of pharmacological agents A purified complex of a metallocorrinoid, such as a vitamin B12 compound, and a pharmacological agent, such as nitric oxide, that is capable of site-specific delivery of the pharmacological agent in vivo. The pharmacological agent is bound to t...	08/10/1999
5869466	Vitamin B₁₂ mediated oral delivery systems for GCSF The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion...	02/09/1999
5869465	Methods of receptor modulation and uses therefor Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are utilized for the treatment and diagnosis of a variety of disorders in warm-blooded animals, including neoplastic disorde...	02/09/1999
5840712	Water soluble vitamin B₁₂ receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo...	11/24/1998
5840880	Receptor modulating agents Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway. The receptor modulating agents are comprised of a covalently bound rerouting moiety and targeting moiety....	11/24/1998
5739313	Radionuclide labeling of vitamin B₁₂ and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is ...	04/14/1998
5589463	Oral delivery of biologically active substances bound to vitamin B12 Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby eli...	12/31/1996
5508271	Treatment of neurological dysfunction with methylcobalamin A method for treating neurological dysfunctions associated with AIDS or ARC comprising the administration of methylcobalamin, alone or in combination with methionine. Substantial increases in the number of T4+ T-lymphocytes, T8+ T-lymphocytes, or the rati...	04/16/1996
5428023	Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof An orally administered complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule, such as vitamin B12 or analogue thereof, and a method for delivering said complex to the intestine of a host vertebrate in order to deliver the ...	06/27/1995
5272250	Boronated phosphoramidate compounds A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are boronated by an aminoalkyl substituted polyborane, carbora...	12/21/1993
4925931	N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain....	05/15/1990
4550163	Ligand analog-irreversible enzyme inhibitor conjugates The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irrev...	10/29/1985
4465775	Vitamin B₁₂ and labelled derivatives for such assay Vitamin B12 in liquid samples, such as human serum or human plasma, is assayed by a competitive binding technique using intrinsic factor and certain labelled vitamin B12 derivatives. The labelled derivatives are formed from the (d)-m...	08/14/1984
4364939	Derivatives of coenzyme B₁₂ Novel monoesters of cobamide derivatives of coenzyme B12 of the formula: ##STR1## wherein R is acyl of an organic carboxylic acid of 4 to 20 carbon atoms and Co is ଱-(5,6-dimethyl-benzimidazolyl)-cobamide which is a mixture of...	12/21/1982
4209614	Vitamin B₁₂ derivative suitable for radiolabeling Radiolabeled vitamin B12 derivatives having the formula ##STR1## wherein R is hydrogen or alkyl of 1 to 3 carbon atoms; n is 0, 1, 2, 3 or 4; and the asterisk (*) indicates tagging with a radioisotope, are useful as tracers in radioassays....	06/24/1980
4133951	Vitamin B-12 cobalt-57 and process A method of making radioactively labelled vitamin B-12 by reacting ଱-(5,6-dimethylbenzimidazolyl)hydrogenobamide with cobaltous ion Co-57, or with another radioactive cobalt isotope. The method enables vitamin B-12 of high specific activity to be ma...	01/09/1979

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Class 536/26.44 - Cobalamin analogs (i.e., compounds wherein the benzimidazole ring system has been replaced by another organic ring structure, or compounds wherein cobalt has been removed or replaced by another metal, or is substituted by a group other than -OH or -CN)