Class 536/26.41 - Processes of preparing or labelling

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Processes for the preparation of cobalamin nucleotide compounds
No. of patents: 28
Last issue date: 09/11/2007

Number	Title	Issue Date
7268119	Tricyclic nucleosides or nucleotides as therapeutic agents Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively. ...	09/11/2007
7232805	Cobalamin conjugates for anti-tumor therapy The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a...	06/19/2007
7220855	Process for producing methylcobalamin The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cyanocobalamin or hydroxocobala...	05/22/2007
7179445	Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ...	02/20/2007
7141233	Radionuclide labeling of vitamin Band coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin,	11/28/2006
7045596	Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated poly...	05/16/2006
6806363	Cobalamin conjugates useful as antitumor agents The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical compositions comprising the compounds, and methods for using the compound...	10/19/2004
6657057	Process for production of methylcobalamin The present invention provides an industrially excellent and novel process for producing methylcobalamin useful as medicines. Namely, it provides a process for producing methylcobalamin, which comprises the step of methylating cyanocobalamin or hydroxocob...	12/02/2003
6518418	Nucleotide sugars Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nu...	02/11/2003
6262253	Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion...	07/17/2001
6211355	Radionuclide labeling of vitamin B12 and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is a chelating gro...	04/03/2001
6187761	Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su...	02/13/2001
6083926	Water soluble vitamin B₁₂ receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo...	07/04/2000
5955321	Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su...	09/21/1999
5808043	Composition for stabilization of labelled nucleoside triphosphates and methods for using same A preparation of a labelled nucleotide comprising at least one compound having a Mg2+ association constant between 1×10-11 to 1×10-2, inclusive. The compound is preferably selected from the group consisting of citrate, ...	09/15/1998
5739287	Biotinylated cobalamins A biotinylated cobalamin, formed from a vitamin B12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B12 molecule is cyanocobalamin. The biotin molecule can also be coupled to a rerouting mo...	04/14/1998
5589463	Oral delivery of biologically active substances bound to vitamin B12 Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby eli...	12/31/1996
5565558	Thioretinaco ozonide and enhanced biological activity of thioretinaco ozonide in combination with interferon Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the polypeptide cytokines, alpha-interferon, beta-interferon, and g...	10/15/1996
5548064	Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion...	08/20/1996
5428023	Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof An orally administered complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule, such as vitamin B12 or analogue thereof, and a method for delivering said complex to the intestine of a host vertebrate in order to deliver the ...	06/27/1995
5405839	Vitamin B₁₂ derivative, preparation process thereof, and use thereof Vitamin B12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from the group consisting of a cyano or adenosyl ...	04/11/1995
5338418	Process for production of hydroxocobalamin A process for the production of hydroxocobalamin that eliminates cyanocobalamin as an intermediate. Co-enzyme-type vitamin B12 is first absorbed to a divinylbenzene/styrene resin which is washed with warm water and then eluted with a solution c...	08/16/1994
4925931	N-homocysteine thiolactonyl retinamido cobalamin and methods of use thereof N-Homocysteine thiolactonyl retinamido cobalamin is useful for decreasing the induction of chemically-induced tumors in animals. It is also useful for inhibiting weight gain....	05/15/1990
4704361	Pharmaceutical compositions containing the cytidine monophospate of 5-acetamido-3,5-dideoxy-D-glycero-D-galactononulosaminic acid and a method for preparing said compound The invention relates to pharmaceutical compositions for use in the therapy of pathological states related to disturbances of the nervous stimulus in the central (CNS) and peripheral (PNS) nervous system containing as an active substance the cytidine mono...	11/03/1987
4550163	Ligand analog-irreversible enzyme inhibitor conjugates The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irrev...	10/29/1985
4465775	Vitamin B₁₂ and labelled derivatives for such assay Vitamin B12 in liquid samples, such as human serum or human plasma, is assayed by a competitive binding technique using intrinsic factor and certain labelled vitamin B12 derivatives. The labelled derivatives are formed from the (d)-m...	08/14/1984
4364939	Derivatives of coenzyme B₁₂ Novel monoesters of cobamide derivatives of coenzyme B12 of the formula: ##STR1## wherein R is acyl of an organic carboxylic acid of 4 to 20 carbon atoms and Co is ଱-(5,6-dimethyl-benzimidazolyl)-cobamide which is a mixture of...	12/21/1982
3936440	Method of labeling complex metal chelates with radioactive metal isotopes A method is provided for labeling a complex metal chelate with a radioactive metal isotope via isotopic exchange between the metal atom of the complex metal chelate and the radioactive metal isotope. The complex metal chelate, in a suitable redox state, i...	02/03/1976

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Class 536/26.41 - Processes of preparing or labelling