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| Number | Title | Issue Date |
| 7745613 | Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be e... | 06/29/2010 |
| 7468432 | Cobalamin conjugates useful as antitumor agents The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical compositions comprising the compounds, and methods for using the compound... | 12/23/2008 |
| 7404489 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 07/29/2008 |
| 7294514 | Diagnostic method for alzheimer's disease based on holo-transcobalamin II The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II. ... | 11/13/2007 |
| 7232805 | Cobalamin conjugates for anti-tumor therapy The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a... | 06/19/2007 |
| 7229636 | Cyanocobalamin low viscosity aqueous formulations for intranasal delivery A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has a viscosity less than about 1000 cPs, and wherein said solution of cy... | 06/12/2007 |
| 7179445 | Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ... | 02/20/2007 |
| 7141233 | Radionuclide labeling of vitamin Band coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: wherein is a cobalamin, | 11/28/2006 |
| 6905884 | Fluorescent cobalamins and uses thereof The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalam... | 06/14/2005 |
| 6894033 | Combination therapies using vitamin B12 and therapeutic agents for treatment of viral, proliferative and inflammatory diseases Pharmaceutical compositions for treating viral, proliferative and inflammatory diseases are disclosed comprising an amount of pharmaceutically acceptable vitamin B12 compounds in combination with anti-viral, anti-proliferative and anti-inflammatory compounds. Vitami... | 05/17/2005 |
| 6838073 | Cobalamin conjugates useful as imaging and therapeutic agents The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis. ... | 01/04/2005 |
| 6830901 | Propionibacteruim vector An endogenous plasmid of Propionibacterium is described, isolated from Propionibacteria freudenreichii LMG 16545 (deposited as CBS 101022), and its sequence provided. This plasmid can be used to transform Propionibacteria to express homologous or heter... | 12/14/2004 |
| 6806363 | Cobalamin conjugates useful as antitumor agents The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical compositions comprising the compounds, and methods for using the compound... | 10/19/2004 |
| 6752986 | Composition and methods for affecting metallocorrinoid uptake The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. ... | 06/22/2004 |
| 6713623 | Tetraphosphonate bicyclic trisanhydrides Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates. ... | 03/30/2004 |
| 6605646 | Vitamin supplement composition A vitamin B12 supplement composition comprising vitamin B12 with and/or without added folic acid that is essentially free of antioxidants, such as vitamin C, as well as iron is disclosed. Also disclosed are methods of using this vita... | 08/12/2003 |
| 6265391 | Method for preventing peripheral nerve damage A vitamin B12 supplement composition comprising vitamin B12 with and/or without added folic acid that is essentially free of antioxidants, such as vitamin C, as well as iron is disclosed. Also disclosed are methods of using this vita... | 07/24/2001 |
| 6262253 | Vitamin B12 conjugates with gcsf, analogues thereof and pharmaceutical compositions The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion... | 07/17/2001 |
| 6255294 | Cyanocobalamin (vitamin B12) treatment in allergic disease Vitamin B12 is administered to allergy patients via mucosal membranes in a series of lozenges and other patient friendly transmucosal modes of delivery given repeatedly over a period of time to reduce the symptoms and IgE antibodies associated ... | 07/03/2001 |
| 6187761 | Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su... | 02/13/2001 |
| 6083926 | Water soluble vitamin B12 receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo... | 07/04/2000 |
| 5955321 | Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su... | 09/21/1999 |
| 5932624 | Vitamin supplement composition A multiple vitamin supplement composition comprising folic acid and vitamin B12 disclosed that is essentially free of antioxidants is disclosed. The multiple vitamin supplement composition may contain vitamin B6. The multiple vitamin... | 08/03/1999 |
| 5869466 | Vitamin B12 mediated oral delivery systems for GCSF The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion... | 02/09/1999 |
| 5869465 | Methods of receptor modulation and uses therefor Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are utilized for the treatment and diagnosis of a variety of disorders in warm-blooded animals, including neoplastic disorde... | 02/09/1999 |
| 5863905 | 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof Optically active antiviral compounds having the formula ##STR1## wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1, and R2 are independently of each... | 01/26/1999 |
| 5840880 | Receptor modulating agents Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway. The receptor modulating agents are comprised of a covalently bound rerouting moiety and targeting moiety.... | 11/24/1998 |
| 5840712 | Water soluble vitamin B12 receptor modulating agents and methods related thereto Vitamin B12 receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are disclosed. The vitamin B12 receptor modulating agents are comprised of a covalently bo... | 11/24/1998 |
| 5739313 | Radionuclide labeling of vitamin B12 and coenzymes thereof A compound useful for in vivo imaging of organs and tumors is provided of formula: ##STR1## wherein ##STR2## is a cobalamin, ##STR3## is derived from a corrin carboxylic acid group of said cobalamin, Y is a linking group and X is ... | 04/14/1998 |
| 5739287 | Biotinylated cobalamins A biotinylated cobalamin, formed from a vitamin B12 molecule coupled to a biotin molecule, is disclosed. In a preferred embodiment, the vitamin B12 molecule is cyanocobalamin. The biotin molecule can also be coupled to a rerouting mo... | 04/14/1998 |
| 5589463 | Oral delivery of biologically active substances bound to vitamin B12 Complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule vitamin B12 and a method for delivering the complex to the intestine of a host vertebrate in order to deliver the complex to the circulation of the host and thereby eli... | 12/31/1996 |
| 5565558 | Thioretinaco ozonide and enhanced biological activity of thioretinaco ozonide in combination with interferon Thioretinaco ozonide and enhancement of the anticarcinogenic, antineoplastic, antiviral, and antiaging activities of thioretinaco ozonide by use of membranergic compositions, specifically the polypeptide cytokines, alpha-interferon, beta-interferon, and g... | 10/15/1996 |
| 5550111 | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNas... | 08/27/1996 |
| 5548064 | Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions The invention describes complexes between VB12 analogues and either GCSF or EPO that retain both significant affinity for intrinsic factor (IF) in the VB12 portion of the complex and significant bioactivity of the GCSF or EPO portion... | 08/20/1996 |
| 5510479 | Hydrophobic vitamin B12 derivatives A novel hydrophobic vitamin B12 derivative represented by the formula: ##STR1## wherein R represents an alkyl group having 2 to 17 carbon atoms, and X represents a cyano group, a hydroxyl group, an alkyl group or a 5'-deoxyadenosyl group. ... | 04/23/1996 |
| 5428023 | Oral delivery of biologically active substances bound to vitamin B12 or analogues thereof An orally administered complex of a drug, hormone, bio-active peptide, or immunogen with the carrier molecule, such as vitamin B12 or analogue thereof, and a method for delivering said complex to the intestine of a host vertebrate in order to deliver the ... | 06/27/1995 |
| 5405839 | Vitamin B12 derivative, preparation process thereof, and use thereof Vitamin B12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from the group consisting of a cyano or adenosyl ... | 04/11/1995 |
| 5272250 | Boronated phosphoramidate compounds A class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated phosphoramidates, and boronated nucleosides, and oligomers thereof. The compounds are boronated by an aminoalkyl substituted polyborane, carbora... | 12/21/1993 |
| 5135918 | Method for decreasing reaginic antibody levels A method for achieving long term relief from the symptoms of atopic allergy, comprising parenteral administration of Vitamin B12 to selected patients, is produced. Vitamin B12 acts to reduce the levels of reaginic antibody (immunoglo... | 08/04/1992 |
| 5026640 | Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth obtained by disruption of microorganism cells in a known manner,... | 06/25/1991 |
