Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8110676 | Prodrugs activated by RNA-dependent DNA-polymerases The invention provides prodrugs activated by RNA-dependent DNA-polymerases, and methods for treating hematological tumors, blood, and blood derivatives from patients affected by retroviral infections by administering the prodrugs. The invention also provides methods... | 02/07/2012 |
| 7371852 | Alkyl-linked nucleotide compositions Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in th... | 05/13/2008 |
| 7368439 | Dinucleoside poly(borano)phosphate derivatives and uses thereof The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X′ each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y′ each independ... | 05/06/2008 |
| 7294619 | Lipid analogs for inhibiting the activity of hepatitis B antigen The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294621 | Lipid analogs for combating tumors The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7294620 | Lipid analogs for inhibiting HIV-1 activity The invention relates to methods of treating viral infections, and in particular hepatitis B virus. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative to inhibit the ... | 11/13/2007 |
| 7291606 | Compositions and methods for identifying agents which regulate chromosomal stability, gene activation and aging Novel compositions and methods are provided for identifying agents which affect chromosomal stability and aging. ... | 11/06/2007 |
| 7285658 | Nucleotide mimics and their prodrugs The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or base-modifications. The nucleotide mimics of the present invention, i... | 10/23/2007 |
| 7223744 | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from... | 05/29/2007 |
| 7161029 | DiL-lysine monosulfate trihydrate crystal and method of making A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature. ... | 01/09/2007 |
| 7132410 | Di(uridine 5′-)tetraphosphate and salts thereof The present invention are directed to P1, P4-di(uridine 5′-)tetraphosphate, tetra-alkali metal salts such as tetrasodium, tetralithium, tetrapotassium, and mixed tetra-alkali metal cations thereof. The tetra alkali metal salts of P1 | 11/07/2006 |
| 7115585 | Compositions for treating epithelial and retinal tissue diseases The present invention relates to mononucleoside phosphate compounds that have the benefits of a dinucleotide pharmaceutical. These mononucleoside phosphates can be made from a mononucleotide that has been modified by attaching a degradation resistant substituent on ... | 10/03/2006 |
| 7091334 | Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large quantities. The methods of the present invention subs... | 08/15/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7078391 | Method of treating edematous retinal disorders The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from... | 07/18/2006 |
| 7026469 | Compositions and methods of double-targeting virus infections and cancer cells The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The compositions o... | 04/11/2006 |
| 6812342 | Esters of cyclic ADP ribose derivatives The present invention is directed to the field of organic chemistry in general and specifically to the preparation of hydrophobic derivatives of cyclic ADP ribose. One form of the present invention is the composition of one or more hydrophobic derivatives of cyclic ... | 11/02/2004 |
| 6790945 | Fluorescent quenching detection reagents and methods Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group. ... | 09/14/2004 |
| 6670341 | Compositions and methods for double-targeting virus infections and targeting cancer cells The invention includes compositions and methods useful for treatment of a virus infection in a mammal by double-targeting the virus (i.e. targeting the virus at more than one stage of the virus life cycle) and thereby inhibiting virus replication. The com... | 12/30/2003 |
| 6660723 | Phosphalohydrins and methods for medicinal administration The invention provides compounds comprising at least one phosphohalohydrin group of the formula: ##STR1## where X is a halogen selected from among I, Br, Cl, R1 is selected from among --CH3 and --CH2 --CH3, Cat+ is an o... | 12/09/2003 |
| 6617444 | Dinucleotide tetraphosphate crystals The present invention is directed to crystals of P1 -(2'-deoxycytidine 5'-)P4 -(uridine 5'-)tetraphosphate (dCP4U) or a salt thereof and to a process for producing the crystals. The present invention also provides a process for produ... | 09/09/2003 |
| 6548658 | Di-(uridine 5')-tetraphosphate and salts thereof The present invention provides methods for the synthesis of a pharmaceutically useful dinucleotide, P1, P4 -di(uridine 5')-tetraphosphate, and demonstrates the applicability to the production of large quantities. The methods of the p... | 04/15/2003 |
| 6479262 | Solid phase enzymatic assembly of polynucleotides The present invention provides methods of preparing large polynucleotides of arbitrary sequence and in a manner that will readily lend itself to automation. The present invention provides methods of preparing a polynucleotide having at least 200 nucleotid... | 11/12/2002 |
| 6448392 | Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral activity which are linked, commonly through a phosphate group a... | 09/10/2002 |
| 6281201 | Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof Antiviral compounds have the formula ##STR1## wherein m is zero, 1, 2 or 3; n is from 1 to 8, preferably 1, 2 or 3; most preferably 1 or 2; R is independently selected from the group consisting of ##STR2## provided that all R may not be ##STR3## R | 08/28/2001 |
| 6222025 | Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom Oligonucleotide analogs are disclosed having pyrimidine monomeric sub-units therein that are modified at the 2' and 5 positions. Monomeric sub-units having these modifications may be further modified at the 2 position. Improved processes for the synthesis... | 04/24/2001 |
| 6114518 | Synthesis and use of labelled phosphoramidite compositions The present invention provides labelled phosphoramidite compositions, methods for making these labelled phosphoramidite compositions, and methods for using these labelled phosphoramidite compositions for labelling oligonucleotides. Even more particularly,... | 09/05/2000 |
| 5872243 | Caged nucleotides The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the... | 02/16/1999 |
| 5852001 | Method and compounds for inhibition of ribonucleases A method of inhibiting ribonucleases is disclosed wherein a nucleotide compound having a diphosphate group contacts a ribonuclease so as to inhibit the ribonuclease from effectively catalyzing the depolymerization of ribonucleic acid. Novel compounds usef... | 12/22/1998 |
| 5834227 | Kit for assaying creatine kinase A reagent for assaying creatine kinase, which contains glucokinase or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate, creatine phosphate, oxidized nicotinamide adenine dinucleotide phosphate, magnesium salt, and glucose; and which... | 11/10/1998 |
| 5739120 | Treatment of viral infections by administration of -1-(3-alkylthio-3-deoxy-2-O-acylglyceryl)!-ω5'-(9-arabino sylpurinyl)! diphosphates or purine isosters thereof The present invention relates to new liponucleotide analog compounds having useful antiviral activity, represented by general formula (I): ##STR1## wherein R1 is a saturated or unsaturated alkyl having 6-22 C atoms; R2 is a satu... | 04/14/1998 |
| 5585481 | Linking reagents for nucleotide probes A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking... | 12/17/1996 |
| 5565555 | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen... | 10/15/1996 |
| 5512671 | Ether lipid-nucleoside covalent conjugates Ether lipid nucleoli covalent conjugates and derivatives thereof are disclosed, along with pharmaceutical compositions containing the same and methods of using the same to combat HIV-1 infections. Illustrative are 3'-Azido-3'-deoxythmidine-5'-monophosphat... | 04/30/1996 |
| 5484911 | Nucleoside 5'-diphosphate conjugates of ether lipids A compound which exhibits antiviral activity having the formula: ##STR1## wherein; R1 is selected from the group consisting of alkyls and alkenyls containing from 8 to 22 carbon atoms; A is selected from the group consisting of O and S atoms; R... | 01/16/1996 |
| 5380715 | Ap4 A as a hypotensive agent A deliberated hypotensive agent is composed of diadenosine 5', 5'"-p1,p4 -tetraphosphate with formula (I) or a salt thereof for which administration is medically permissible in an effective amount: ##STR1##... | 01/10/1995 |
| 5219841 | Treatment of arrhythmia by administration of Ap4 A The present invention relates to a pharmaceutical composition for treating a heart disease which comprises a therapeutically effective amount of diadenosine 5',5'"-P1, P4 -tetraphosphate as an active ingredient in admixture with a ph... | 06/15/1993 |
| 5159067 | 5'-Diphosphohexose nucleoside pharmaceutical compositions Compounds of the general formula: ##STR1## wherein A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or N-acetyl aldohexosamin... | 10/27/1992 |
| 5049550 | Diadenosine 5', 5'"-p1, p4,-tetraphosphate analogs as antithrombotic agents A component of blood platelets analogues thereof are described. The invention is based on the discovery that this component, a dinucleotide, as well as several of its chemically synthesized analogues, is an effective anti-platelet and antithrombotic agent... | 09/17/1991 |
| 4958013 | Cholesteryl modified oligonucleotides Oligonucleotides modified at their backbones by the attachment of cholesteryl are described. The modified oligonucleotides anchor in the cell membrane to serve as a probe and to provide therapeutic activity.... | 09/18/1990 |
