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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 7063944 | Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular d... | 06/20/2006 |
| 7063978 | Coated film laminate having an electrically conductive surface Articles including a polymeric substrate and an electrically conductive surface are provided. Methods of making and using such articles also are provided. ... | 06/20/2006 |
| 7060816 | Detection of fungal pathogens using the polymerase chain reaction The present invention relates to the use of primers in polymerase chain reaction assays for the detection of fungal pathogens Colletotrichum acutatum, Alternaria spp., and Cladosporium carpophilum. Specific primers are identified as being useful for th... | 06/13/2006 |
| 7060435 | Genotyping cytochrome expression There is disclosed a method of identifying subjects having a high or low drug metabolising phenotype associated with cytochrome CYP3A5 expression, which method comprises screening genomic DNA from said subject for the presence or absence of one or more polymorphic v... | 06/13/2006 |
| 7060809 | LNA compositions and uses thereof Modified LNA units are provided that comprises unique base groups. Desirable nucleobase and nucleosidic base substitutions can mediate universal hybridization when incorporated into nucleic acid strands. The novel LNA compounds may be used in a wide variety of appli... | 06/13/2006 |
| 7057027 | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The o... | 06/06/2006 |
| 7056670 | Sequencing method Disclosed is a single molecule sequencing method comprising the steps of: a) attaching a molecule to a solid phase; b) incubating the molecule with a first composition comprising a first reporter moiety; c) detecting incorporation of said first reporter moiety; d) p... | 06/06/2006 |
| 7056706 | Shot-gun sequencing and amplification without cloning Disclosed is a method for sequencing and amplifying nucleic acid templates wherein a degenerate primer with a fixed sequence region and a random sequence region is utilized. By determining the statistical expectancy of the fixed sequence in the nucleic acid template... | 06/06/2006 |
| 7056676 | Method for sequencing nucleic acid molecules The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the acti... | 06/06/2006 |
| 7056661 | Method for sequencing nucleic acid molecules The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the acti... | 06/06/2006 |
| 7057025 | Binary probe and clamp composition Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection of PCR products, by real-time and end-point measurements. Where the p... | 06/06/2006 |
| 7056705 | Multiplex PCR primer set for human glucokinase gene amplification The present invention provides a primer pooi for amplifying a target sequence of a human glucokinase gene including at least one set of primers or variant primers thereof, each set of primers being identified by two consecutive SEQ ID NOS, the SEQ ID NOS starting at... | 06/06/2006 |
| 7052860 | Identification of antigens for use in the diagnosis, treatment, and monitoring of periodontal diseases Antibodies, polypeptides, and polynucleotides are provided for the detection, prevention, amelioration and treatment of diseases caused by Actinobacillus actinomycetemcomitans. ... | 05/30/2006 |
| 7052876 | Combinatorial method for producing nucleic acids A method of generating novel nucleic acid molecules, by applying a combinatorial approach to the assembly of blocks of nucleic acid sequence, is described. By using restriction endonucleases having different recognition sites but which produce compatible cleavage pr... | 05/30/2006 |
| 7052846 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid molecules based upon size is required. ... | 05/30/2006 |
| 7052847 | Method for sequencing nucleic acid molecules The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the acti... | 05/30/2006 |
| 7052890 | Transglutaminase gene products The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10A, FIG. 6B or FIG. 10A or FIG. 10B; nucleotides which hybridise to the nucleotide sequences of FIG. 6A, FIG. 6B ... | 05/30/2006 |
| 7052835 | Method of screening a gene The present invention provides a method of screening genes based on expression information differing from gene expression information obtainable by DNA chip/DNA microarray techniques. The method of screening genes comprises performing in situ hybridization in respec... | 05/30/2006 |
| 7052841 | Systems, tools and methods of assaying biological materials using spatially-addressable arrays Systems, tools and methods of assaying biological material are used to perform complex sandwich hybridization assays. The tools used comprise biological solution probes that are customized for each assay. The solution probe comprises a first region for hybridizing t... | 05/30/2006 |
| 7052834 | Tumor suppressor protein involved in death signaling, and diagnostics, therapeutics, and screening based on this protein The present invention relates to identification of tumor suppressor activity of a protein, caspase-8 (CASP8), and to related diagnostic and therapeutic compositions and methods. The discovery of this tumor suppressor activity provides screening targets as well, part... | 05/30/2006 |
| 7053206 | Methods and compositions for multiplex amplification of nucleic acids A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a function of the length of the amplicon and the length of other amplicons be... | 05/30/2006 |
| 7049430 | Method of treating HIV infection and related secondary infections thereof Defibrotide including its nucleic acid components and the variants thereof can be used to treat various disease conditions. Such therapeutic compounds can also be administered in combination with other nucleic acids and peptides. ... | 05/23/2006 |
| 7045291 | Multiplex PCR for the detection of AmpC beta-lactamase genes Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain AmpC beta-lactamases. The primers can be employed in methods to detect the presence or absence of an AmpC beta-lactamase gene in samples, and to identify nucleic acid c... | 05/16/2006 |
| 7041450 | Method for diagnosing GH deficiency The present invention relates to a method and kit for diagnosing GH (growth hormone) deficiency, in particular isolated growth hormone deficiency II (IGHD II). The method comprises the steps of analysing the missense mutation G6191 to T in exon 4 of GH-1 ... | 05/09/2006 |
| 7041451 | Electrochemiluminescence helicase assay The present invention relates to electrochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a clas... | 05/09/2006 |
| 7041452 | Method of detecting the presence of absence of mixed varieties in grains, and identifying the mixed varieties Provided is a DNA-level grain variety discrimination method of detecting the presence or absence of any other varieties of grains in object grains of a certain variety through multiplex PCR that uses the DNAs extracted from the grains or from their processed product... | 05/09/2006 |
| 7041255 | Detection of dengue virus The present invention relates to a pair of dengue virus-specific primers for use in a reverse transcriptase-polymerase chain reaction to detect dengue virus. ... | 05/09/2006 |
| 7041810 | Alpha-2 adrenergic receptor polymorphisms The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detec... | 05/09/2006 |
| 7041443 | Porcine reproductive and respiratory syndrome virus and methods of use The present invention provides isolated European-like porcine reproductive and respiratory syndrome viruses, polynucleotides, and polypeptides. The present invention also provides methods for making antibodies to the viruses and polypeptides, methods for detecting p... | 05/09/2006 |
| 7041811 | Method for detecting Specific nucleic acid sequences, e.g., SEQ ID NOs: 1–8, for detecting Escherichia coli. Also disclosed is a method of detecting Escherichia coli. The method includes providing a sample having a nucleic acid from an unknown microorganism; amplifying t... | 05/09/2006 |
| 7038030 | BIVM (basic, immunoglobulin-like variable motif-containing) gene, transcriptional products, and uses thereof The subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translational products obtained from the polynucleotide sequences of the invention. The subject invention also provides polynucleotide and polypeptide sequences provided by... | 05/02/2006 |
| 7037655 | Method of judging flocculating properties of bottom brewer's yeast The present invention provides a reproducible method to determine flocculating properties of bottom fermenting yeast, at a short time, easily and quickly, without fermentation. It is characterized in using an ORF sequence of a flocculation gene FLO5 of laboratory's ... | 05/02/2006 |
| 7037651 | Genetic marker test for lupus Disclosed is a genetic testing method for diagnosing systemic lupus erythematosus (SLE) in a human subject. The method is related to amplifying nucleic acids from human tissue samples and detecting the presence or absence of variant alleles of a gene encoding poly(A... | 05/02/2006 |
| 7037649 | Immobilized nucleic acid and method for detecting nucleic acid A nucleic acid to be immobilized and used for hybridization of nucleic acids using an immobilized nucleic acid, which has a polymer comprising a compound having an unsaturated bond, said polymer being bonded to the 3′ end or 5′ end or both ends of the nucleic ac... | 05/02/2006 |
| 7038038 | Synthesis of 5-azacytidine The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylat... | 05/02/2006 |
| 7037682 | In vitro activity assay for human hepatitis B virus (HBV) DNA polymerase, and its use for screening for inhibitors of HBV DNA polymerase The present invention provides an in vitro activity assay for human hepatitis B virus (HBV) DNA polymerase, which comprises using, as the 5′ oligonucleotide in PCR amplification of HBV DNA polymerase from a sample, an oligonucleotide into which has been incorporat... | 05/02/2006 |
| 7037650 | Cancer diagnostic method based upon DNA methylation differences There is disclosed a cancer diagnostic method based upon DNA methylation differences at specific CpG sites. Specifically, the inventive method provides for a bisulfite treatment of DNA, followed by methylation-sensitive single nucleotide primer extension (Ms-SNuPE),... | 05/02/2006 |
| 7037688 | Method for using unequal primer concentrations for generating nucleic acid amplification products The method provided herein is a method for detecting a target sequence in a test sample. Generally, the method comprises forming a reaction mixture comprising a test sample, amplification reagents, a first primer, and a second primer wherein the concentration of the... | 05/02/2006 |
| 7034145 | Directionally cloned random cDNA expression vector libraries, compositions and methods of use The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense orientation. Also provided are random cDNA expression vector libraries, comprising expression vectors which comprise... | 04/25/2006 |
| 7033764 | Method for sequencing nucleic acid molecules The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the acti... | 04/25/2006 |
