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| Number | Title | Issue Date |
| 7169939 | Energy transfer dyes with enhanced fluorescence Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor... | 01/30/2007 |
| 7169584 | Tracer reagents that enhance reaction-product analysis A composition suitable for formulation of an enzymatic reaction mixture, the composition comprising a reaction component essential for an ex-vivo non-polymerase enzymatic reaction in which a substrate is catalyzed by an enzyme in a reaction mixture to form a product... | 01/30/2007 |
| 7169555 | Method for indentifying microbial DNA or RNA The invention relates to a method for quickly detecting bacterial DNA. The sample containing bacterial DNA is provided and treated according to a PCR method. The DNA copies which are multiplied by means of PCR are detected. ... | 01/30/2007 |
| 7169552 | Detection of polymorphisms in AFLP fragments using primer extension techniques The present invention relates to a method for determining the genotypes of polymorphic loci amplified in a mixture of restriction fragments, using an oligonucleotide sequence that is essentially complementary to part of the target restriction fragment, and located a... | 01/30/2007 |
| 7169553 | 2-Azapurine compounds and their use Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaad... | 01/30/2007 |
| 7166430 | Sequence of the tropheryma whippelii bacteria rpoB gene and oligonucleotide for molecular diagnosis of whipple's disease The invention concerns the total sequence of the Tropheryma whippelii bacteria rpoB gene, characterized in that it consists of the nucleotide sequence SEQ ID no. °9, and the nucleotide sequences derived from said sequence specific of the Tropheryma whippelii | 01/23/2007 |
| 7160997 | Methods of using FET labeled oligonucleotides that include a 3′→5′ exonuclease resistant quencher domain and compositions for practicing the same Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labele... | 01/09/2007 |
| RE39464 | Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages Novel chiral compounds that mimic and/or modulate the activity of wild-type nucleic acids are disclosed. In general, the compounds are phosphorothioate oligonucleotides wherein the 5′, and the 3′-terminal internucleoside linkages are chirally Sp and internal int... | 01/09/2007 |
| 7157572 | UV excitable energy transfer reagents Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 01/02/2007 |
| 7157229 | Prepatterned substrate for optical synthesis of DNA probes An optical alignment system for a device for synthesizing DNA polymers provides for a patterned substrate for simple alignment of the system. The substrate may also be used for synthesis allowing precise alignment of the synthesis substrate during each synthesis ope... | 01/02/2007 |
| 7157436 | Therapeutically useful synthetic oligonucleotides The present invention provides a composition and method comprising a 2–20 base 3′-OH, 5′-OH synthetic oligonucleotide (sequence) selected from the group consisting of (GxTy)n, (TyGx)n, a(Gx... | 01/02/2007 |
| 7153654 | Assay procedure using fluorogenic tracers Fluorescent energy transfer dyes capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope or nucleic acid for use in the detection of an unk... | 12/26/2006 |
| 7148342 | Compositions and methods for sirna inhibition of angiogenesis RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpressio... | 12/12/2006 |
| 7148044 | Nucleic acid enzyme for RNA cleavage A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7 nucleotide sequence with at least 6 nucleotides 3′ to the cleavage site an... | 12/12/2006 |
| 7144999 | Modulation of hypoxia-inducible factor 1 alpha expression Compounds, compositions and methods are provided for modulating the expression of hypoxia-inducible factor 1 alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding hypoxia-inducible factor 1 alpha. Methods of using these compounds for m... | 12/05/2006 |
| 7141377 | Process for discrimination of nucleic acid sequence variants A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for det... | 11/28/2006 |
| 7141364 | Universal primers for wildlife identification The invention provides novel universal primers that can amplify the fragment of cytochrome b gene of any animal species in polymerase chain reaction (PCR) and reveal the identity of the biological material of any unknown animal origin and a method for identification... | 11/28/2006 |
| 7141417 | Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions o... | 11/28/2006 |
| 7138254 | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and the reaction is ... | 11/21/2006 |
| 7135284 | Primer extension methods for production of high specific activity nucleic acid probes The present invention provides novel nucleic acid labeling techniques that generate nucleic acid probes with specific activities at least ten fold higher than the levels obtained using standard labeling methods. Specifically, the methods of the invention provides me... | 11/14/2006 |
| 7135333 | Compositions that specifically bind to colorectal cancer cells and methods of using the same A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colore... | 11/14/2006 |
| 7135283 | Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms Novel polymorphisms of prokaryotic topoisomerase type II Gyr A, Gyr B and parC gene loci are provided. These polymorphisms differentiate very closely related organisms and provide a means to identify pathogenicity and drug resistance. For example, drug resistance su... | 11/14/2006 |
| 7132266 | Method and kit for analyzing target nucleic acid fragment A method of analyzing a target nucleic acid fragment is provided that is capable of being performed simply and promptly, by anyone, using a compact device without requirement of specific technique or complex operation. The method comprises timely detection of a doub... | 11/07/2006 |
| 7132530 | Antisense modulation of superoxide dismutase 1, soluble expression Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismuta... | 11/07/2006 |
| 7132235 | Reagent kit for determining specific nucleotide variations Detection of variable nucleotide(s) is based on primer extension and incorporation of detectable nucleoside triphosphates. By selecting the detection step primers from the region immediately adjacent to the variable nucleotide, this variation can be detected after i... | 11/07/2006 |
| 7132238 | Method of determining a chemotherapeutic regimen based on ERCC1 expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a ... | 11/07/2006 |
| 7132239 | Determination of a genotype of an amplification product at multiple allelic sites A method is provided for genotyping a target sequence at at least two allelic sites by a 5′ nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid amplification on a target sequence having at least two different allelic s... | 11/07/2006 |
| 7129041 | Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be ... | 10/31/2006 |
| 7129223 | Inhibition of SARS-associated coronavirus (SCoV) infection and replication by RNA interference The present invention relates to therapeutic agents useful for the treatment of Severe Acute Respiratory Syndrome (SARS) in humans. In particular, the present invention relates to RNA interference (RNAi) molecules useful for inhibiting the infection and replication ... | 10/31/2006 |
| 7129045 | Methods of detecting polynucleotide kinase and its use as a label Methods of detecting or measuring the activity of polynucleotide kinase are disclosed as well as methods of detecting an analyte in an assay using polynucleotide kinase as a label on a member of a specific binding pair. The methods rely on the phosphorylation of an ... | 10/31/2006 |
| 7125691 | Method for determining the efficiency of nucleic acid amplifications The present invention concerns a method for determining the efficiency of the amplification of a target nucleic acid comprising the following steps: (i) preparation of a dilution series of the target nucleic acid, (ii) amplifying the target nucleic acid under define... | 10/24/2006 |
| 7125972 | Solid carriers with peptide nucleic acid probes and methods for regeneration A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex... | 10/24/2006 |
| 7125978 | Promoter for regulating expression of foreign genes The present invention relates to a promoter for regulating expression of foreign genes in transgenic organisms, which comprises a promoter having the identifying characteristics of a promoter having a sequence selected from the group consisting of sequences set fort... | 10/24/2006 |
| 7125661 | Sequences for the detection of An isolated nucleic acid molecule comprising a nucleotide sequence encoding a transcriptional enhancer of cytochrome P450 (P450) CYP3A4 production or expression is disclosed, as are uses of the nucleic acid molecule for screening compounds for xenobiotic induction o... | 10/24/2006 |
| 7122310 | Methods of constructing self-assembly of probes and method of detecting the same The present invention provides a novel method for forming a self-assembly substance of probes making it possible to shorten a reaction time required for formation of a self-assembly substance and also to increase regions of probes available for detection of a target... | 10/17/2006 |
| 7118892 | Automated process for preparing and amplifying a target nucleic acid sequence An automated process for preparing and amplifying a target nucleic acid sequence within a stand-alone unit. ... | 10/10/2006 |
| 7118870 | Detection of fecal contamination using nucleic acid molecules that recognize bacterial 16S rDNA sequences Herein disclosed are nucleic acid sequences that can be used to detect fecal contamination in a sample. In one embodiment, the probes and primers disclosed herein can be used to identify the host species that is the source of fecal bacterial contamination in the sam... | 10/10/2006 |
| 7115400 | Methods of nucleic acid amplification and sequencing Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified or sequenced, wherein said nucleic acid(s) to be amplified or sequence... | 10/03/2006 |
| 7115374 | Compositions and methods for detecting West Nile virus Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers for detecting very low levels of West Nile virus nucleic acids. ... | 10/03/2006 |
| 7112419 | Human hepatoma associated protein and the polynucleotide encoding said polypeptide The invention relates to a new kind of human protein associated with hepatoma and the polynucleotide encoding the polypeptide and a process for producing the polypeptide by recombinant methods. The present invention also relates to a method of applying the polypepti... | 09/26/2006 |
