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| Number | Title | Issue Date |
| 6989233 | Method and device for analyzing nucleic acids immobilized on a support A process for characterizing, quantifying or mapping a nucleic acid or a nitrogenous base fixed on a support by using a photothermal (mirage effect) method. An improved process for manufacturing a nucleic acid biochip on which at least one nucleic acid synthesized i... | 01/24/2006 |
| 6989250 | Method for in vitro molecular evolution of protein function The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired cha... | 01/24/2006 |
| 6989267 | Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films Methods for stably associating a polyelectrolyte coating or film to a substrate surface, as well as the coated substrates produced thereby, are disclosed herein. In the subject methods, substrate surfaces are coated with a polyelectrolyte, and the coated substrate s... | 01/24/2006 |
| 6986989 | Nanoparticles having oligonucleotides attached thereto and uses therefor The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparti... | 01/17/2006 |
| 6986987 | Genetic polymorphism in the receptor for IgA A method and a package for identifying single nucleotide polymorphisms in FcαRI is useful in identifying individual susceptibility to a disease. FcαRI is active as a cellular receptor of IgA. The susceptibility and severity of an IgA related disease is determined ... | 01/17/2006 |
| 6984491 | Nanoparticles having oligonucleotides attached thereto and uses therefor The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparti... | 01/10/2006 |
| 6984729 | Oligonucleotides specific for hepatitis B virus The present invention discloses synthetic oligonucleotides complementary to contiguous and noncontiguous regions of the HBV RNA. Also disclosed are methods and kits for inhibiting the replication and expression of HBV, and for treating HBV infections and associated ... | 01/10/2006 |
| 6982325 | Gene encoding protein having aurone synthesizing activity The present invention provides a protein having aurone synthase activity involved in the color of flowers such as snapdragons, a gene that encodes it, cDNA in particular, and its applications. This gene can give yellow color to the flowers of plants by introducing i... | 01/03/2006 |
| 6982149 | Fiber array and methods for using and making same An apparatus and method are provided for contacting at least two chemical species, comprising a support plate having a channel for receiving a mobile chemical species and a fiber, having a second chemical species immobilized thereon, disposed on the support plate. A... | 01/03/2006 |
| 6982143 | Normalizing and amplifying RNA The invention provides methods and compositions for normalizing and amplifying RNA populations. The methods generally comprise the steps of copying message RNA (mRNA) to form first single-stranded (ss) cDNA; converting the first ss-cDNA to first double-stranded (ds)... | 01/03/2006 |
| 6979733 | Epoxide hydrolases, nucleic acids encoding them and methods of making and using them The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are us... | 12/27/2005 |
| 6977162 | Rapid analysis of variations in a genome The invention provides a method useful for determining the sequence of large numbers of loci of interest on a single or multiple chromosomes. The method utilizes an oligonucleotide primer that contains a recognition site for a restriction enzyme such that digestion ... | 12/20/2005 |
| 6977163 | Methods and systems for performing multiple reactions by interfacial mixing Methods and systems of performing multiple reactions in a high throughput format by utilizing interfacial mixing of adjacently positioned reagent slugs in a fluid conduit. Preferred applications of the methods and systems are in performing biochemical analyses, incl... | 12/20/2005 |
| 6977161 | Solid support assay systems and methods utilizing non-standard bases Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target oligonucleotide. In some instances, the molecular recognition sequence incl... | 12/20/2005 |
| 6974696 | PRO853 nucleic acids The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 12/13/2005 |
| 6974866 | Retrovirus from the HIV type O and its use (MVP-2901/94) A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the v... | 12/13/2005 |
| 6974666 | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nucl... | 12/13/2005 |
| 6974672 | Gene amplification in cancer There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are amplified colon cancer and/or ovarian cancer and/or breast cancer genes. The... | 12/13/2005 |
| 6972328 | Non-aggregating non-quenching oligomer comprising nucelotide analogs, method of synthesis and use thereof The invention provides compositions and methods for improved hybridization analysis utilizing DNA, RNA, PNA and chimeric oligomers in which one or more purine bases are substituted by a pyrazolo[5,4-d]pyrimidine or by a 7-deazapurine purine analogue. Reduced self-ag... | 12/06/2005 |
| 6969761 | Nanoparticles having oligonucleotides attached thereto and uses therefor The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparti... | 11/29/2005 |
| 6969704 | Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject The invention provides a method for reducing damage to an ischemic tissue which comprises contacting cells of the tissue with an inhibitor of Early Growth Response Factor-1 Protein (Egr-1). In addition, the invention provides a method for reducing vascular injury du... | 11/29/2005 |
| 6967079 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; | 11/22/2005 |
| 6962780 | Method for synthesis of nucleic acids The present invention is a method for synthesis of nucleic acids to amplify an intended nucleic acid in a region in which a GC content is rich, wherein a polyhydric alcohol and/or ammonium sulfate is present in an amplification reaction solution. According to the pr... | 11/08/2005 |
| 6960656 | Nucleic acid encoding DS-CAM proteins and products related thereto In accordance with the present invention, there are provided Down Syndrome-Cell Adhesion Molecule (DS-CAM) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention DS-CAM proteins can be employed in a variet... | 11/01/2005 |
| 6958211 | Methods of assessing HIV integrase inhibitor therapy Methods and products for the evaluation of HIV treatment are provided. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of tho investigated compounds. The methods rely on providing an integrase gene ... | 10/25/2005 |
| 6958213 | Method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing sin... | 10/25/2005 |
| 6958214 | Polymorphic kinase anchor proteins and nucleic acids encoding the same Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herei... | 10/25/2005 |
| 6958225 | Complexity management of genomic DNA The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for amplification of a subset of the sequences in a sample. In a preferred embodiment, amplification of a subs... | 10/25/2005 |
| 6958239 | Three component chimeric antisense oligonucleotides This invention relates to antisense oligonucleotides that target mRNAs in cells as substrates for the cellular enzyme RNase H and thereby cause specific degradation of the targeted mRNA. The oligonucleotides have three components: an RNase H activating region, a com... | 10/25/2005 |
| 6955876 | Compositions and systems for identifying and comparing expressed genes (mRNAs) in eukaryotic organisms The invention comprises compositions and systems to identify and compare expressed genes in a given in vivo or in vitro RNA sample, as well as the relative difference in mRNA expression between two or more samples, where desired. Furthermore, the invention comprises... | 10/18/2005 |
| 6955875 | Mutations associated with iron disorders The invention features a method of diagnosing an iron disorder, e.g., hemochromatosis, or a genetic susceptibility to developing such a disorder in a mammal by determining the presence of a mutation in exon 2 or in an intron of an HFE nucleic acid. ... | 10/18/2005 |
| 6955901 | Multiplex ligatable probe amplification Described is an improved multiplex ligation-dependent amplification method for detecting the presence and quantification of at least one specific single stranded target nucleic acid sequence in a sample using a plurality of probe sets of at least two probes, each of... | 10/18/2005 |
| 6956111 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 10/18/2005 |
| 6953659 | Direct, externally imposed control of nucleic acids Methods and compositions for rendering nucleic acids directly responsive to an external signal utilizing modulators that themselves respond to the external signal and are associated with the nucleic acid. In response to the external signal, the modulator alters phys... | 10/11/2005 |
| 6951722 | Method for amplifying nucleic acid sequence A convenient and effective method for amplifying a nucleic acid sequence characterized by effecting a DNA synthesis reaction in the presence of chimeric oligonucleotide primers; a method for supplying a large amount of DNA amplification fragments; an effective metho... | 10/04/2005 |
| 6951726 | Real-time PCR assay of the bacterium Edwardsiella ictaluri in channel catfish A rapid and sensitive PCR-based assay is provided to facilitate early detection of Edwardsiella ictaluri in channel catfish. This bacteria is the causative agent in the disease, Enteric septicemia of catfish (ESC). Also provided is a method of selecting breed... | 10/04/2005 |
| 6951724 | Methods for detection of ataxia telangiectasia mutations The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electroph... | 10/04/2005 |
| 6949633 | Primers useful for sizing nucleic acids The present invention provides modified oligonucleotide primers designed to incorporate a cleavable moiety so that a 3′ portion of the primer (linked to an extension product) can be released from an upstream 5′ portion of the primer. Upon selective cleavage of t... | 09/27/2005 |
| 6949637 | Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma. ... | 09/27/2005 |
| 6949379 | Aptamer-mediated regulation of gene expression This invention provides methods of regulating gene expression. An aptamer is positioned in a nucleic acid molecule along with a sequence encoding a transcriptional regulatory polypeptide. The aptamer disrupts translation of the transcriptional regulatory polypeptide... | 09/27/2005 |
