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| Number | Title | Issue Date |
| 8114599 | Compositions and methods for free-solution conjugate nucleic acid analysis The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed single-base extension assays for genotyping. In particular, the present inventi... | 02/14/2012 |
| 8097416 | Methods for identification of sepsis-causing bacteria The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis. ... | 01/17/2012 |
| 8067568 | Method for diagnosing spinal muscular atrophy A method for diagnosing spinal muscular atrophy is provided. The method includes providing a biological sample of a subject containing a nucleotide of SMN gene, amplifying SMN exons 1, 2a, 2b, 3, 4, 5, 6, 7, and 8 by a unive... | 11/29/2011 |
| 8048631 | Reducing non-target nucleic acid dependent amplifications: amplifying repetitive nucleic acid sequences The present invention provides for compositions and methods for amplifying target nucleic acids using nucleic acid primers designed to limit non-target nucleic acid dependent priming events. The present invention permits amplifying and quantitating the number of rep... | 11/01/2011 |
| 8043809 | Real-time PCR point mutation assays for detecting HIV-1 resistance to antiviral drugs Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comp... | 10/25/2011 |
| 8034920 | Nucleic acid primers and probes for detecting breast cells Polynucleotides are provided which are useful as amplification primers and hybridization probes for detecting BS106 target sequence in a test sample. The primers and probes can be employed in amplification based methods for detecting the presence of BS106 sequences ... | 10/11/2011 |
| 8017337 | Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other me... | 09/13/2011 |
| 8013142 | Compositions for use in identification of bacteria The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis. ... | 09/06/2011 |
| 7981617 | Transcription template for cell-free protein synthesis and method using the same Methods to construct a transcription template for cell-free protein synthesis that has a high translation template activity, using a 3′-side primer and a 5′-side primer for PCR are provided. The 5′-side primer for PCR has a sequence complementary to a base seq... | 07/19/2011 |
| 7973154 | Kits for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine sample, with or without isolation of nucleic acids from a urine sample. The ... | 07/05/2011 |
| 7956175 | Compositions for use in identification of bacteria The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis. ... | 06/07/2011 |
| 7910720 | Polyanion for improved nucleic acid amplification The present invention is directed to a novel chemical compound comprising the structure [Xx-(CH2)m-phosphate-Yy]n, characterized in that 3≦m≦6, 30≦n≦60, each x and y is independently from each other 0 or 1, each X and Y is independently from each other any p... | 03/22/2011 |
| 7897750 | Strategies for gene expression analysis The invention provides methods for screening compound or chemical libraries by analyzing expressed RNA samples from biological samples treated with members of a compound library in a high throughput format. ... | 03/01/2011 |
| 7897749 | Dairy cattle breeding for improved milk production traits in cattle Nucleic acid molecules comprising a SNP site selected from the group consisting of position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), position 213 of bovine signal transducer and activator of transcription (STAT1) coding sequence (SE... | 03/01/2011 |
| 7872116 | Identification of cell culture contaminants among Mollicutes species by a PCR based assay The present invention encompasses nucleic acids, methods, compositions, and kits for sensitive, rapid and specific detection of Mycoplasma, Acholeplasma, Ureaplasma, Phytoplasma and Spiroplasma species in a sample. The invention utilizes specific prime... | 01/18/2011 |
| 7858768 | Detection and distinguishing infectious bursal disease virus (IBDV) strains by molecular biology method The present invention relates to a novel method to detect and differentiate different strains of infectious bursal disease virus (IBDV) in a chicken and other bird sample. RNA was obtained from said samples by using a pair of primer (Primer FVVC & RVVC) in a reverse... | 12/28/2010 |
| 7847087 | Methods and primers for evaluating HIV-1 mutations Primer sequences and a method of using such sequences for the genotyping of HIV-1-containing samples, particularly those which have failed genotyping analysis are provided using primer sequences designed for analysis of Group B subtype of the Group M type virus. For... | 12/07/2010 |
| 7847088 | Classification and diagnosis of the molecular basis of cholestasis The methods and compositions of the invention find use in the clinical diagnosis of cholestasis related syndromes, particularly PFIC types 1, 2, and 3; BRIC types 1 and 2; Alagille syndrome, and alpha1-antitrypsin deficiency. The compositions of the invention includ... | 12/07/2010 |
| 7829692 | Primer composition and a kit useful for the identification of phyllanthus The present invention relates to an oligonucleotide primer set useful for the identification of Phyllanthus at species level, and more particularly, it relates to an oligonucleotide primer set useful for the identification of Phyllanthus species select... | 11/09/2010 |
| 7803929 | Kits for diagnosis and monitoring of pathogenic infection by analysis of cell-free pathogenic nucleic acids in urine The present invention relates to a method for diagnosing and/or monitoring a bacterial or parasitic infection by detection and quantification of the transrenal nucleic acids, derived from bacterial pathogenic agents or from parasites, in urine. The detection method ... | 09/28/2010 |
| 7790876 | Sequences diagnostic for foot and mouth disease Methods and materials for the detection of the foot and mouth disease virus (FMDV). The methods may utilize PCR amplification, with or without an internal positive control, and appropriate primer pairs. The reagents to perform these methods can be supplied as a kit ... | 09/07/2010 |
| 7754870 | Method and compositions for detecting Provided are an oligonucleotide primer set for amplifying at least one target sequence of the cagA gene of Helicobacter pylori, a method of detecting Helicobacter pylori using the primer set, and a kit for detecting Helicobacter pylori, includin... | 07/13/2010 |
| 7732589 | Primers for amplifying hsp 65 gene of mycobacterial species, hsp 65 gene fragments and method of identifying mycobacterial species with the same The present invention relates to a pair of primers specific to mycobacterial species, a polynucleotide of an hsp 65 gene fragment, and a method for the identification of mycobacterial species by using the same. More specifically, the 604-bp hsp 65 gene fragment can ... | 06/08/2010 |
| 7723507 | Diagnostic test for Collie Eye Anomaly The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and t... | 05/25/2010 |
| 7718790 | Kit for assessing mitochondrial toxicity Processes and methods for the simultaneous quantification of nucleic acids in diseased cells that are based on real-time PCR are provided. The real-time PCR protocol is an excellent tool for reliable quantification of in vitro drug screening and evaluation protocols... | 05/18/2010 |
| 7709627 | Oligonucleotide primer set for amplifying target sequence(s) of norovirus, oligonucleotide probe or probe set specifically hybridizing with target sequence(s) of norovirus, microarray immobilized with the probe or probe set, and method of detecting norovirus using the probe or probe set Provided are an oligonucleotide primer set for amplifying at least one target sequence of the genomic RNA of norovirus, an oligonucleotide probe or probe set specifically hybridizing with at least one target sequence of the genomic RNA of norovirus, a microarray imm... | 05/04/2010 |
| 7700756 | Metabolic primers for the detection of perchlorate-reducing bacteria and methods of use thereof The present invention is directed to metabolic primers for the detection of perchlorate-reducing bacteria and methods and compositions for use of the same in environmental bioremediation. ... | 04/20/2010 |
| 7696341 | Corn event DAS-59122-7 and methods for detection thereof The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome ... | 04/13/2010 |
| 7691994 | Compositions and methods for the detection of human T cell receptor variable family gene expression Compositions and methods for the assessment of T cell receptor variable subunits. The present invention provides nucleotide sequences for the evaluation of the expression of TCRV families. These nucleotides sequences were obtained through a bioinformatic investigati... | 04/06/2010 |
| 7667026 | Population scale HLA-typing and uses thereof The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within... | 02/23/2010 |
| 7619080 | Oligonucleotides of a chicken leukemia inhibitory factor (LIF) gene The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention p... | 11/17/2009 |
| 7612193 | Primers for exons of variants of RHCE and RHD genes Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instea... | 11/03/2009 |
| 7585965 | Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal molecule areas that are incorporated stably into the metal oxide layer. The ... | 09/08/2009 |
| 7560543 | Method of determining a chemotherapeutic regimen based on and expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and pr... | 07/14/2009 |
| 7557204 | CUDR as biomarker for cancer progression and therapeutic response Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy. ... | 07/07/2009 |
| 7544792 | Compositions and methods for detection of hepatitis A virus nucleic acid Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences a... | 06/09/2009 |
| 7517978 | Modified oligonucleotides and applications thereof Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof. ... | 04/14/2009 |
| 7495094 | Detection reagent for thermostable direct hemolysin-related hemolysin gene of A detection reagent for detecting thermostable direct hemolysin-related hemolysin (TRH) gene in an amplification process which specifically amplifies TRH1 and TRH2 RNA, which reagent comprises a first primer having a sequence complementary to a specific sequence of ... | 02/24/2009 |
| 7491814 | Real-time RT-PCR for the sensitive detection of multiple MAGE gene transcripts The present invention relates to a highly sensitive real-time RT-PCR method for specifically detecting the expression of more than one MAGE gene. The present invention further relates to a diagnostic composition for carrying out such a real-time RT-PCR as well as to... | 02/17/2009 |
| 7473775 | Abortive promoter cassettes The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally compr... | 01/06/2009 |