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| Number | Title | Issue Date |
| 6849261 | CD4-independent HIV envelope proteins as vaccines and therapeutics The invention relates to novel CD4-independent HIV Envelope proteins and uses therefor. ... | 02/01/2005 |
| 6849780 | Plants resistant to cucumber mosaic virus strain V34 The CP gene of CMV strain V34 (CMV-V34) is provided. ... | 02/01/2005 |
| 6846905 | Antigen constructs useful in the detection and differentiation of antibodies to HIV Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constr... | 01/25/2005 |
| 6846665 | Method of producing a recombinant adeno-associated virus, suitable means for producing the same and use thereof for producing a medicament The present invention relates to a method for producing a recombinant adeno-associated virus (rAAV), in which at different times a helper construct and also a vector construct are introduced into a suitable cell, and preferably the helper construct does not comprise... | 01/25/2005 |
| 6844192 | Adenovirus E4 protein variants for virus production A method of packaging a recombinant viral vector is carried out by: (a) providing a packaging cell, the packaging cell containing and expressing a nucleic acid encoding a mutant adenovirus E4orf6 protein, the E4orf6 protein containing at least one mutation that rend... | 01/18/2005 |
| 6843992 | Immuno-reactive peptide CTL epitopes of human cytomegalovirus The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent human cytomegalovirus (HCMV) inf... | 01/18/2005 |
| 6841158 | Recombinant celo virus and celo virus DNA Recombinant CELO virus or CELO virus DNA with a deletion at the right end of the viral genome that allows insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in particular birds, and for gene therapy and vaccine applications in hu... | 01/11/2005 |
| 6838084 | Cytotoxic T-cell epitopes of the papilloma virus l1-protein and use thereof in diagnosis and therapy The present invention relates to a papillomavirus T-cell epitope having an amino acid sequence ILVPKVSGL (SEQ ID NO: 1), RLVWACVGV (SEQ ID NO: 2), HLFNRAGTV (SEQ ID NO: 3), YLRREQMFV (SEQ ID NO: 4), TLQANKSEV (SEQ ID NO: 5), ILEDWNFGL (SEQ ID NO: 6), SLWLPSEATVYL (S... | 01/04/2005 |
| 6835568 | Regulated nucleic acid expression system The present invention provides nucleic acid constructs, expression systems, and methods relating to the regulation of gene expression. The invention may be applied to regulate the expression of any coding sequence of interest, including those coding for viral compon... | 12/28/2004 |
| 6830748 | Recombinant RSV virus expression systems and vaccines The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant ... | 12/14/2004 |
| 6831169 | Hepatitis C virus vaccine Nucleic acid molecule that comprise an incomplete hepatitis C viral genome are provided. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C... | 12/14/2004 |
| 6830920 | Rapid generation of recombinant adenoviral vectors The invention provides a novel Adenovirus backbone plasmid, which when co-transfected with a shuttle vector, allows for production of recombinant viruses quickly and easily. The present invention also provides host cells and a cloning system for generating recombina... | 12/14/2004 |
| 6828138 | Recombinant sendai virus vector including a gene encoding a chemokine A recombinant Sendai virus vector expressing chemokine is provided. This vector enables large quantity production of clinically useful chemokines. It is also useful for treatment of diseases that can be treated by chemokines. ... | 12/07/2004 |
| 6824784 | Cold-adapted equine influenza viruses The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine influenza virus, wherein the equine influenza virus genome segment confers at ... | 11/30/2004 |
| 6818425 | RNA ligase of bacteriophage RM 378 A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described. ... | 11/16/2004 |
| 6818628 | Polynucleotide vaccine formula in particular against bovine respiratory pathology Disclosed and claimed are compositions for inducing in a bovine host an immunological response against bovine respiratory syncytial virus or bovine viral diarrhea virus containing at least one plasmid that contains and expresses in vivo in a bovine host cell nucleic... | 11/16/2004 |
| 6814969 | Immunologically significant herpes simplex virus antigens and methods for using same The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have de... | 11/09/2004 |
| 6811970 | Assay for identifying inhibitors of HIV RT dimerization A method for measuring heterodimerization of HIV RT, which comprises the steps of: a) providing a first solution comprising p66 subunit homodimers in the presence of a dissociation agent; b) contacting the first solution with p51 RT subunits and incubating in... | 11/02/2004 |
| 6812379 | Expression of eukaryotic peptides in plant plastids Constructs and methods are provided for expressing peptides derived from eukaryotic organisms in plant plastids. Constructs have a promoter functional in a plant plastid, a DNA sequence encoding a peptide derived from an eukaryotic organism and a transcription termi... | 11/02/2004 |
| 6808923 | Episomally replicating lentiviral vectors The invention is directed to a lentiviral vector system that can be used for episomal replication of a desired gene. The vector system contains a first vector containing a lentiviral gag gene encoding a lentiviral gag protein, a second vector containing an env gene ... | 10/26/2004 |
| 6806080 | Hybrid vectors for gene therapy The invention discloses hybrid vectors for delivering genes or other nucleic acids into mammalian cells. The hybrid vectors of the invention contain both a helper dependent adenoviral portion and a second portion derived from a transposon. Such vectors provide effic... | 10/19/2004 |
| 6806064 | Baculovirus enhancer-like sequence The invention features nucleic acid constructs and related methods useful for the high level expression of a heterologous protein in a cell, e.g., an insect cell. The constructs include an enhancer-like sequence located upstream from the polyhedrin gene locus in the... | 10/19/2004 |
| 6800475 | Isolation of a human retrovirus The present invention comprises compositions and methods comprising a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the methods and compositi... | 10/05/2004 |
| 6800463 | Method for mutation detection in HIV-1 using pol sequencing The present invention relates to a method of for mutation analysis of the HIV pol gene of HIV-1 virions comprising amplifying viral RNA or DNA via nested PCR using outer primers as represented in SEQ ID No: 1 and 2, amplifying said PCR product via nested PCR using a... | 10/05/2004 |
| 6800288 | Recombinant influenza A viruses The invention relates to a recombinant NS gene of an influenza A virus comprising a functional RNA binding domain and a gene sequence modification after nucleotide position 400 of the NS1 gene segment, counted on the basis of influenza A/PR/8/34 Virus, wherein the m... | 10/05/2004 |
| 6797506 | Recombinant, replication defective CELO virus and CELO virus DNA Recombinant CELO virus or CELO virus DNA with a deletion or disruption of the Gam1 gene, optionally combined with deletions at the right or left end of the viral genome that allow insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals... | 09/28/2004 |
| 6797491 | Human papilloma virus treatment Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disc... | 09/28/2004 |
| 6797512 | Selection system for generating efficient packaging cells for lentiviral vectors A method for selecting packaging cells that express high levels of gag/pol is provided. ... | 09/28/2004 |
| 6793926 | Methods for production of a recombinant adeno-associated virus This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be point-mutated or deleted viruses, and methods of producing those viruses. Th... | 09/21/2004 |
| 6794129 | Method for measuring anti-protease resistance of HIV-2 in a patient A search method in a biological sample containing an HIV 2 viral strain for possible resistance of said strain to treatment by an anti-protease agent, and nucleotide probes for the implementation thereof. According to methods known per se, the presence of at least o... | 09/21/2004 |
| 6790657 | Lentivirus vector system A method is disclosed for improving encapsidation of transgene RNA using retroviral packaging and transfer vectors. An HIV-2 transfer vector, which includes the transgene, is introduced into a packaging cell that is also transfected with (or stably expresses) an HIV... | 09/14/2004 |
| 6790952 | Quantitative epstein barr virus PCR rapid assay The present invention provides novel compositions comprising Epstein-Barr virus-specific oligonucleotides that are useful as primers to amplify particular regions of the genome during enzymatic nucleic acid amplification. The invention also provides a rapid, sensiti... | 09/14/2004 |
| 6784164 | Choline binding proteins for anti-pneumococcal vaccines The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also p... | 08/31/2004 |
| 6783939 | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof o... | 08/31/2004 |
| 6783981 | Anti-viral vectors A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and effecting the cleavage, directly or indirectly, of a second nucleotide sequenc... | 08/31/2004 |
| 6783763 | Polyepitopic proteinic fragments of the E6 and E7 HPV proteins, production and use thereof in vaccines Polyepitopic fragments of the E6 or E7 protein of HPV comprise a peptide sequence of about 15 to 30 amino acids. This peptide sequence contains amino acid sequences of at least 3 different epitopes binding stably to HLA molecules of identical or different type, when... | 08/31/2004 |
| 6773908 | Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV) The present invention provides an isolated DNA sequence encoding, for example, at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndro... | 08/10/2004 |
| 6774225 | Antigenized antibody vaccine for foot-and-mouth disease A vaccine for treatment of foot-and-mouth disease of swine is provided. This vaccine is an antigenized antibody vaccine created from the grafting of peptide epitopes derived from FMDV into swine antibody CDR loops. FMDV peptide epitopes are cloned by PCR from VP1 ge... | 08/10/2004 |
| 6770752 | Sequences for detection of HIV-1 Primers and probes derived from the HIV-1 pol gene which facilitate detection and/or quantification of all presently known genotypes of HIV-1 (A-I and O). Disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of HI... | 08/03/2004 |
| 6762031 | Targeting viral vectors to specific cells Methods for creating viral display libraries for purposes of isolating variants with modified target cell specificity and related methods; also retroviral display libraries. ... | 07/13/2004 |
