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Class 536/21 - Heparin or derivative


Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which are polysaccharides containing the following
No. of patents: 352
Last issue date: 01/24/2012


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NumberTitleIssue Date
4405612Heparin web compositions
Microfibrous heparin salts, nonwoven webs of such fibers, a process for preparing the fibers and the use of the webs for the rapid heparinization of blood are disclosed....
09/20/1983
4401662Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a USP titer in a ratio of at least 30. They consist of chains constituted by no more th...
08/30/1983
4401758Process for making oligosaccharides having anti-Xa activity and the resulting oligosaccharides
Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a USP titer in a ratio of at least 30. They consist of chains substituted by no more than 8 ...
08/30/1983
4396762Heparinase derived anticoagulants
There is disclosed a heparin product obtained by degradation of heparin with heparinase from Flavobacterium heparinum (ATCC 13125) or mutants thereof having activity to reduce the coagulation activity of factor X while not effecting the coagulation activi...
08/02/1983
4386025Method of preparing antithrombin
A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the...
05/31/1983
4385046Diagnostic radio-labeled polysaccharide derivatives
A novel class of chelated radio-labeled polysaccharide derivatives are useful for diagnosing formed, and forming, blood clots in a vascular system. Novel intermediate metal-binding compounds comprise a water-soluble polysaccharide moiety having an average...
05/24/1983
4351938Anticoagulant substance
Partially depolymerized heparin products having particular analyzable reducing end groups, a process for their preparation and their use as anticoagulants and antithrombotics....
09/28/1982
4346216Osmium carbohydrate complexes
Osmium carbohydrate complexes prepared by reacting osmium compounds and carbohydrates and their utilization as pharmaceutical compositions for the treatment of heavy metal poisoning and arthritis in mammals. The osmium carbohydrate complexes may also be u...
08/24/1982
4343736Process for recovering interferon
A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub...
08/10/1982
4331697Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
A heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR1## wherein R1, R2 and R3 each represent a hydrogen atom or an alkyl group...
05/25/1982
4329383Non-thrombogenic material comprising substrate which has been reacted with heparin
Non-thrombogenic material comprising a base polymer treated with heparin, the improvement in which the heparin is covalently bonded with the base polymer through only one acetal bond or hemiacetal bond at each bonding site between the heparin and the base...
05/11/1982
4315923Process for the production of organ extracts with high herparin content
A process for producing an aqueous solution of high heparin content from heparin-containing animal organs comprises forming a heparin-enriched granular raw material from these organs and extracting the raw material at a temperature of 20° to 80° C. with...
02/16/1982
4314935Process for recovering interferon
A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolub...
02/09/1982
4303651Heparin fragments having selective anticoagulation activity
Heparin fragments having selective anticoagulation activity having 14-18 sugar units, the disaccharide unit L-iduronosyl-2-O-sulphate-N-sulpho-U-glucosamine-6-O-sulphate being the main component, and where unsulphated L-iduronic acid is in a position ...
12/01/1981
4301153Heparin preparation
A heparin preparation which exhibits elevated anticoagulant activity and a process for producing the preparation. Conventional heparin exhibiting characteristic anticoagulant activity and molecular heterogeneity is incubated with antithrombin-heparin cofa...
11/17/1981
4301067Chitin containing poly-ion complex
This invention relates to a poly-ion complex comprising chitin or N-acylchitosan derivative having carboxymethyl and polyelectrolyte....
11/17/1981
4283530Process for the preparation of heparin
Heparin is extracted from intestinal brine, i.e., from the brine which results from the preservation and dewatering treatment of animal tissue with sodium chloride, using conventional methods. The extracted product has a high activity and can subsequently...
08/11/1981
4281108Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained
The present invention relates to a process for obtaining low molecular weight heparins endowed with pharmacological and therapeutic properties of outstanding interest, starting from normal heparin. The said process is characterized in that it comprises the fol...
07/28/1981
4260741Low-density xanthan gums
A form of xanthan gum is disclosed which is less dense than regular xanthan gum and which exhibits an increased hydration rate....
04/07/1981
4250041Removal of heparin from blood plasma samples using an insoluble protamine reaction product
This invention relates to a method for the removal of heparin from heparin-containing plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a...
02/10/1981
4239754Liposomes containing heparin and a process for obtaining them
Heparin-based preparations wherein heparin is retained in or on liposomes. The lipids of said liposomes are preferably phospholipids comprising acyl chains derived from non saturated fatty acids, advantageously essential acids. These heparin-liposomes preparat...
12/16/1980
4226599Removal of heparin from heparin-containing blood plasma samples using a triethylaminoethyl cellulose tablet
A tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from abo...
10/07/1980
4192916Process for producing defatted heparin tissue for heparin production
An improved process for producing defatted heparin tissue is disclosed wherein frozen heparin-bearing tissue is particulated, thawed and warmed in a heat exchanger, fermented at temperatures ranging from about 60°-85° F. for 5 to 12 hours and subjected ...
03/11/1980
4188467Process for tempering tissue for heparin production
An improved method of tempering frozen heparin-bearing animal tissue is disclosed wherein the frozen tissue is particulated, thawed and warmed in a heat exchanger and fermented at temperatures ranging from about 60°-85° F. for 5-12 hours. Putrefaction a...
02/12/1980
4175182Separation of high-activity heparin by affinity chromatography on supported protamine
An affinity chromatography method for the separation of high-activity heparin from a mixture thereof with low-activity heparin. The method employs an affinity column of protamine coupled to a water-insoluble solid support material such as agarose, and a s...
11/20/1979
4168377Process of preparing mixed heparin salts
Mixed or simple heparin salt having a reduced amount of a selected metal ion alone or with another metal ion in a mixed heparin. A heparin salt having a reduced sodium content being essentially sodium free and having a selectively high calcium or other se...
09/18/1979
4122250Separation of high-activity heparin by affinity chromatography
An affinity chromatography method for the separation of high-activity heparin from a mixture thereof with low-activity heparin. The method employs an affinity column of DEAE-Sephadex and a series of sodium chloride-imidazole elution buffers (pH 6.5-7.5) v...
10/24/1978
4119774Heparin purification method
Crude clinically used heparin preparations having a low specific activity, for example, about 130 heparin units per milligram are purified by contacting such liquid crude heparin preparations with a gel matrix complexed with (i.e. having linked to it) ant...
10/10/1978
4118485Non-thrombogenic medical article and a method for its preparation
A medical article is made non-thrombogenic by means of a surface coating containing heparin. The heparinized surface is stabilized by being contacted first with a cationic surfactant of the primary amine type and, subsequently, with a dialdehyde....
10/03/1978
4082727Method for manufacture of non-coagulative organosilicone polymer
A non-coagulative organosilicone resin is produced by causing an organosilicon compound containing an isocyanate group and possessing a siloxane-forming property to react with heparin in order to produce an organosilicon compound having a heparin residue ...
04/04/1978
3932627Siver-heparin-allantoin complex
Silver-heparin-allantoin complex and process for making same is disclosed. The silver-heparin-allantoin complex is prepared by a novel process in either powder or solution form. The silver-heparin-allantoin complex provides a non-thrombogenic, self-steril...
01/13/1976
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